Treatment of children with Down syndrome and growth retardation with recombinant human growth hormone

Torrado, C.; Bastian, William; Wisniewski, K. E.; Castells, Salvador

doi:10.1016/s0022-3476(05)82068-2

Cited by 43 publications

(23 citation statements)

References 24 publications

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“…Thus, previous findings of improved fine motor skill [67] and an increased head circumference [68] could theoretically be an effect of improved cerebellar maturation and growth during GH treatment, as a high density of IGF-I receptors in the cerebellum has been reported [84]. The presence of GH receptors has been confirmed in the human putamen [35] and in the rat and rabbit cerebellum [85].…”

Section: Growth Hormone and Motor Perfor-mancementioning

confidence: 65%

“…The available data on GH therapy in DS are unanimous, with the reported effects entirely beneficial [33,[67][68]. There is a marked response to exogenous GH treatment in DS [33,[67][68], despite the previous findings of reasonable GH concentrations in DS children [33] and observations of normal GH secretion in young adults with DS.…”

Section: Growth Hormone Therapymentioning

confidence: 97%

“…It has been found that GH therapy normalises the growth velocity, but "catch-down" growth was noted when the treatment was discontinued [33,67]. Furthermore, Torrado et al [68] reported an increase in head circumference SDS during GH treatment in children with DS, but no information on psychomotor function was given in that report.…”

Section: Growth Hormone Therapymentioning

confidence: 98%

“…Very few investigations on GH treatment in children with DS have been performed [33,67,68]. However, from studies of the GH effect in other conditions, it may be concluded that GH has positive cognitive effects in children with PWS [62,63], TS [64] and GHD [64,65], as well as in children born SGA [66].…”

Section: Growth Hormone and Cognitive Functionmentioning

confidence: 99%

“…There are some reports on GH treatment in children with DS [33,[67][68]. It has been found that GH therapy normalises the growth velocity, but "catch-down" growth was noted when the treatment was discontinued [33,67].…”

Section: Growth Hormone Therapymentioning

confidence: 99%

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Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System: Growth Hormone in Down Syndrome

Myrelid¹

2012

TOEJ

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Down syndrome (DS) is a chromosomal disorder associated with short stature and psychomotor delay. Growth hormone (GH) and insulin-like growth factor I (IGF-I) are of interest in DS as the pronounced growth retardation coincides in time when GH becomes essential for growth. Simultaneously mean intelligence quotient (IQ) decreases markedly.There is no evidence of a general GH deficiency in children with DS, but suboptimal endogenous production of GH and selective deficiency of IGF-I have been demonstrated. GH and IGF-I are important brain growth promoting factors. IGF receptors are present in brain cells from foetuses with DS, but there is no information as to whether disturbances of intracerebral GH binding or IGF-I production may contribute to the brain dysfunction in DS.GH therapy normalized growth velocity and improved fine motor performance in young children with DS, but the limited therapy was followed by a marked "catch-down" growth and lacked effect on final height. In adolescents with DS treatment with GH during early childhood show some positive late effects, where subjects previously treated had greater head circumference and improved performance regarding cognitive function and motor skills.Few studies have addressed the effect of GH in Down syndrome. Nevertheless, GH has been designated beneficial effects on cognition, energy, mood and behaviour through extensive studies in several other conditions and it is not unlikely that GH may have similar effects in DS. It should be emphasised that even small changes in psychomotor attainment may be of substantial importance in a developmentally delayed population.

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Section: Growth Hormone and Motor Perfor-mancementioning

confidence: 65%

Section: Growth Hormone Therapymentioning

confidence: 97%

Section: Growth Hormone Therapymentioning

confidence: 98%

Section: Growth Hormone and Cognitive Functionmentioning

confidence: 99%

Section: Growth Hormone Therapymentioning

confidence: 99%

See 3 more Smart Citations

Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System: Growth Hormone in Down Syndrome

Myrelid¹

2012

TOEJ

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Profiling of circulating chromosome 21‐encoded microRNAs, miR‐155, and let‐7c, in down syndrome

Pérez-Villarreal

Aviña-Padilla

Beltrán-López

et al. 2022

Molec Gen & Gen Med

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Complementary and alternative therapies for Down syndrome

Roizen

2005

Ment. Retard. Dev. Disabil. Res. Rev.

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In their role as committed advocates, parents of children with Down syndrome have always sought alternative therapies, mainly to enhance cognitive function but also to improve their appearance. Nutritional supplements have been the most frequent type of complementary and alternative therapy used. Cell therapy, plastic surgery, hormonal therapy, and a host of other therapies such as massage therapy have been used. There is a lack of well-designed scientific studies on the use of alternative therapies in individuals with Down syndrome. Antioxidants hold theoretical promise for treatment of the cognitive, immune, malignancy, and premature aging problems associated with Down syndrome. Medications for treatment of Alzheimer's disease may also result in benefit for the population of individuals with Down syndrome.

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Treatment of children with Down syndrome and growth retardation with recombinant human growth hormone

Cited by 43 publications

References 24 publications

Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System: Growth Hormone in Down Syndrome

Current Knowledge on Growth Hormone and Insulin-Like Growth Factors and their Role in the Central Nervous System: Growth Hormone in Down Syndrome

Profiling of circulating chromosome 21‐encoded microRNAs, miR‐155, and let‐7c, in down syndrome

Complementary and alternative therapies for Down syndrome

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