Treatment of Carpal Tunnel Syndrome With Vitamin B6 A Double-Blind Study

Stransky, M.; Rubin, Arline M.; Ns, Lava; Rp, Lazaro

doi:10.1097/00007611-198907000-00011

Cited by 43 publications

(17 citation statements)

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“…Stransky [40] clinical and electrophysiological CTS (1) pyridoxine 200 mg/day for 10 weeks Improvement in symptoms in 50 % (2), 80 % (n = 6 patients) (2) and 75 % (3) after 10 weeks, but no (2) placebo tablets (n = 5 patients) significant differences between the groups. because some patients received extra injections, and the moment of outcome assessment for them was different to that for patients who received no additional treatment.…”

Section: Pyridoxinementioning

confidence: 99%

See 1 more Smart Citation

Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials

Gerritsen¹,

Krom

Struijs³

et al. 2002

Journal of Neurology

185

122

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Section: Pyridoxinementioning

confidence: 99%

“…In 1 high quality [39] and 1 low quality [40] RCT the effect of pyridoxine was evaluated. Neither study found any significant differences in symptom improvement between the treatment groups, indicating moderate evidence (level 2) that pyridoxine and placebo are equally effective.…”

Section: Pyridoxinementioning

confidence: 99%

Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials

Gerritsen¹,

Krom

Struijs³

et al. 2002

Journal of Neurology

185

122

View full text Add to dashboard Cite

“…The most commonly used outcome measures were those related to symptoms of CTS. A wide variety of those measures were used including the following: specific descriptions of symptoms (eg, pain, paraesthesias), 11,13 more general expressions (eg, night discomfort or just symptoms), 10,14 combinations of symptoms (eg, night/day pain/paraesthesias, global symptom score), 13,16,18 measures relating to improvement of symptoms (eg, symptoms improved/changed/worsened), 15 or severity of symptoms (eg, main complaints: no complaints at all [0] to the most intense complaints I can imagine [10]). 12 Because pooling of heterogeneous outcomes will lead to an uninterpretable and misleading pooled estimate, meta-analysis is not feasible.…”

Section: Resultsmentioning

confidence: 99%

Enabling meta-analysis in systematic reviews on carpal tunnel syndrome

Gerritsen

Vet

Scholten

et al. 2002

The Journal of Hand Surgery

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Possible solutions to the problems of clinical heterogeneity of outcome measures and inadequate reporting of results for randomized controlled trials (RCTs) on carpal tunnel syndrome (CTS) are presented. Meta-analysis was impeded by these problems in 2 systematic reviews concerning conservative and surgical treatment options for CTS. A solution to the problem of inadequate data presentation is to add explicit information on minimal requirements with regard to data presentation to guidelines for the reporting of studies. To resolve the problem of clinical heterogeneity of the outcomes there should be consensus on the (validated) outcomes that should be used in RCTs. For CTS there is little evidence available on the reliability, validity, and responsiveness to change of the commonly used outcomes in RCTs.Resolving both problems will increase the comparability of RCTs, enabling the calculation of a pooled estimate of effect in a meta-analysis. Systematic reviews of high-quality, randomized controlled trials (RCTs) are considered to be the highest level of evidence in research concerning medical interventions. 1 To quantify the effect of the various treatment options, preferably a meta-analysis is performed. By combining individual study results a precise estimate of the magnitude of the treatment effect can be obtained. Meta-analysis is, therefore, an important part of a systematic review. Meta-analysis is only feasible if RCTs are clinically homogeneous, that is, if the patients, interventions, comparisons, outcomes, and timing of follow-up measurements are sufficiently similar. 2 Randomized controlled trials, however, may use a range of different outcome measures. 3,4 Another prerequisite for combining study results is adequate and uniform data presentation. Reporting of results in biomedical journals is often inadequate. 5,6 This article presents possible solutions to the problems of clinical heterogeneity of the outcome measures and inadequate reporting of results for RCTs on carpal tunnel syndrome (CTS). First we show, however, that meta-analysis was impeded by these problems in 2 systematic reviews concerning conservative and surgical treatment options for CTS. 7,8

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“…Vitamin B6'nın konservatif KTS tedavisinde herhangi bir avantaj sağlamadığı sonucuna varılmıştır (26). Bizim olgularımızda vitamin-B kompleksi verilen grupta FDS, SŞS ve VAS değerlerinde anlamlı iyileşme saptandı.…”

Section: Yöntemlerunclassified

The Effects of Vitamin B and Tendon-Nerve Stretching Exercises on Clinical and Electrophysiological Parameters in the Treatment of Carpal Tunnel Syndrome

Biçer¹,

Çabalar²,

Ecerkale³

2014

Istanbul Med J

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Amaç: Elektrofizyoloji laboratuarımızda karpal tünel sendromu (KTS) tespit edilen olguların tedavisinde B vitamini ile tendon ve sinir germe egzersizlerinin (TSGE) klinik ve elektrofizyolojik parametreler üzerine etkisi incelendi.Yöntemler: Elektrofizyoloji laboratuarımızda KTS tanısı alan ve B vitaminisplint (Grup 1) ile TSGE-splint tedavisi uygulanan (Grup 2) olgularda tedavilerin etkinliği 3 ayın sonunda fonksiyonel durum skalası (FDS), semptom şiddet skalası (SŞS), görsel değerlendirme skalası (VAS) ve elektromiyografi (EMG) ile istatistiksel olarak değerlendirildi. Bulgular Sonuç:Karpal tünel sendromu tedavisinde kullanılan B vitamini ve germe egzersizlerinin etkinliği değerlendirildiğinde olguların şikayetlerinde azalma ve klinik değerlendirmelerinde bunun göstergesi olan VAS, FDS ve SŞS' da anlamlıyken, EMG'de düzelme görülmekle birlikte istatistiksel olarak anlamlı değildi. Uygulanan bu tedavi yöntemleri özellikle duysal semptomların ön planda olduğu KTS tedavisinde kullanılabilir.Anahtar Kelimeler: Karpal tünel sendromu, görsel değerlendirme skalası, semptom şiddet skalası, B vitamini, tendon-sinir germe egzersizleri Objective: In our electrophysiology laboratory, in the cases diagnosed with carpal tunnel syndrome (CTS), the effects of vitamin B and the tendon and nerve stretching exercises (TNSE) on clinical and electrophysiological parameters were analyzed. Methods:In our electrophysiology laboratory, in the cases which were diagnosed with CTS and vitamin B-splint (Group 1) with TNSE-splint treatment (Group 2) was practiced the efficiency of the treatment was evaluated statistically with the functional situation scale (FSS) at the end of three months period, the symptom severity scale (SSS), the visual analog scale (VAS) and electromyography EMG. Results:Of the 45 cases between the ages of 29-66 years (average: 47.86±9.74), 32 were diagnosed with bilateral, and 13 were diagnosed with unilateral CTS (n=77 hand). In the EMG 52 sensory (S), 25 sensory and motor (S+M) effectswere determined. In Group 1, there were 23 S, 13 S+M, in Group 2 there were 29 S, 12 S+M effects. After the treatment 11 cases were electrophysiologically normal, there was S in 41, and S+M in 25. Between Group 1 and Group 2, before and after the treatment, a meaningful relationship was not t observed. However, when the effects of EMG on the values of the FSS, SSS and VAS were analyzed, a meaningful improvement was observed in the measurements of FSS and VAS (p<0.05) whereas this was not observed in the measurements of SSS (p>0.05). Conclusion:When the efficiency of vitamin B and the stretching exercises which were used in the carpal tunnel syndrome were analyzed, a decrease in the complaints of the cases and in VAS, FSS and SSS as indicators of the clinical evaluations of it was meaningful whereas in the EMG, although an improvement was seen, this was not statistically meaningful. This treatment method can be used especially in CTS treatment where sensory symptoms are at the forefront.Key Words: Carpal tunnel syndrome, the visual an...

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Treatment of Carpal Tunnel Syndrome With Vitamin B6 A Double-Blind Study

Cited by 43 publications

References 0 publications

Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials

Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials

Enabling meta-analysis in systematic reviews on carpal tunnel syndrome

The Effects of Vitamin B and Tendon-Nerve Stretching Exercises on Clinical and Electrophysiological Parameters in the Treatment of Carpal Tunnel Syndrome

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