Treatment of canine cranial cruciate ligament disease

Duerr, Felix M.; Martin, Kyle W.; Rishniw, Mark; Palmer, Ross H.; Selmic, Laura E.

doi:10.3415/vcot-14-03-0047

Cited by 79 publications

(14 citation statements)

References 24 publications

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“…The TPLO is the most common orthopedic surgery for stabilization of cranial cruciate ligament deficient stifles in dogs [12,13]. Patients undergoing a TPLO and other orthopedic procedures are often subjected to activity restriction, and the development of disuse muscle atrophy following orthopedic injuries has been documented [15].…”

Section: Discussionmentioning

confidence: 99%

“…Cranial cruciate ligament (CCL) rupture is the most common stifle injury in medium and large breed dogs, ultimately resulting in pain, lameness, and secondary muscle atrophy of the affected limb [9]. While various surgical procedures are described for the repair of CCL rupture, the tibial plateau leveling osteotomy (TPLO) is the most common repair technique for the cranial cruciate ligament deficient stifle, with the ultimate goal of providing functional stifle joint stability [10][11][12][13]. There have not been any studies addressing the effect of disuse muscle atrophy on stifle joint stability or on interventions to mitigate disuse muscle atrophy in dogs with CCL rupture.…”

Section: Introductionmentioning

confidence: 99%

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Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy

et al. 2020

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“…CrCLR surgical treatment was selected to examine the study hypothesis, as CrCLR is one of the most frequent orthopedic conditions in dogs (1). CrCLR management through surgery has been well accepted, even if the type of stabilization remains a matter of debate (48). Clinical studies performed with client-owned animals are powerful, as these studies integrate all “real life” variables that may not be considered in studies performed with an experimental model, enabling the translation of the results to the field with a good level of confidence (49).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study

Taroni

Cabon

Febre³

et al. 2017

Front. Vet. Sci.

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ObjectiveCompare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs).Study designProspective, double-blinded, randomized, controlled, monocentric clinical study.AnimalsSixteen client-owned dogs.Materials and methodsDogs with unilateral CrCLR confirmed by arthroscopy were included. Allogeneic neonatal canine MSCs were obtained from fetal adnexa retrieved after C-section performed on healthy pregnant bitches. The dogs were randomly allocated to either the “MSCs group,” receiving an IA injection of MSCs after TPLO, followed by placebo for 1 month, or the “NSAIDs group,” receiving IA equivalent volume of MSCs vehicle after TPLO, followed by oral NSAID for 1 month. One of the three blinded evaluators assessed the dogs in each group before and after surgery (1, 3, and 6 months). Clinical score and gait and bone healing process were assessed. The data were statistically compared between the two groups for pre- and postoperative evaluations.ResultsFourteen dogs (nine in the MSCs group, five in the NSAIDs group) completed the present study. No significant difference was observed between the groups preoperatively. No local or systemic adverse effect was observed after MSCs injection at any time point considered. At 1 month after surgery, bone healing scores were significantly higher in the MSCs group. At 1, 3, and 6 months after surgery, no significant difference was observed between the two groups for clinical scores and gait evaluation.ConclusionA single IA injection of allogeneic neonatal MSCs could be a safe and valuable postoperative alternative to NSAIDs for dogs requiring TPLO surgery, particularly for dogs intolerant to this class of drugs.

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“…The TPLO is currently the most commonly recommended procedure by veterinary surgeons for the treatment of CCL rupture. 10,27 That said, several other procedures exist and may be alternatively selected for the treatment of CCL rupture. The TPLO is a dynamic osteotomy-based procedure that neutralizes tibiofemoral shear force during weight bearing.…”

Section: Clinical Outcome With Tplomentioning

confidence: 99%

<p>Tibial Plateau Leveling Osteotomy for Cranial Cruciate Ligament Rupture in Canines: Patient Selection and Reported Outcomes</p>

Nanda¹,

Hans²

2019

VMRR

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Cranial cruciate ligament (CCL) rupture is one of the most common causes of pelvic limb lameness in dogs. In a CCL deficient stifle, joint lameness develops from cranial tibial translation in relation to the distal femoral condyles. The tibial plateau leveling osteotomy (TPLO) is a well-described surgical procedure that neutralizes tibiofemoral shear force by altering the tibial plateau via a proximal tibial osteotomy, and subsequently restores normal limb function. Current literature for the TPLO was reviewed and used to describe the optimal patient selection and to report clinical outcome with the TPLO in comparison to other surgical options for CCL rupture. The clinical outcomes reported to date, particularly those utilizing objective outcome data, support the TPLO as being able to consistently return dogs to normal limb function with a low risk for long-term morbidity. The TPLO procedure was found to be widely applicable to dogs ranging from small breed to large and giant breed, and does not appear to have some of the limitations that exist with alternative surgical options. This review concludes that the TPLO is an excellent treatment option for any dog with CCL rupture due to the excellent long-term outcome and high rate of owner satisfaction previously reported. Despite these conclusions, it is important to remember that treatment selection for CCL rupture remains dependent on multiple considerations including patient factors, surgeon experience, and costs.

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Treatment of canine cranial cruciate ligament disease

Abstract: Extracapsular stabilization and TPLO are the most commonly employed surgical procedures in the surveyed population; dog size and activity level (but not age) are the major factors influencing treatment decisions.

Cited by 79 publications

References 24 publications

Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy

Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy

<p>Tibial Plateau Leveling Osteotomy for Cranial Cruciate Ligament Rupture in Canines: Patient Selection and Reported Outcomes</p>

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