Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy

White, Dana A.; Harkin, Kenneth R.; Roush, James K.; Renberg, Walter C.; Biller, David S.

doi:10.1371/journal.pone.0231306

Cited by 11 publications

(37 citation statements)

References 18 publications

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“…Our findings are in contrast with those of the White et al study, which is the only other study evaluating the effects of Fortetropin on myostatin in dogs (13). In that study, serum myostatin levels were measured in dogs with a cranial cruciate ligament (CCL) injury that was treated with a TPLO.…”

Section: Discussioncontrasting

confidence: 98%

“…As has been recognized in human myostatin research, the ideal assay for assessing circulating myostatin in dogs is not yet established, making evaluation of therapeutics designed to inhibit myostatin challenging. Objective measures such as thigh circumference, total pressure index, and protein synthesis may provide a better assessment of the effect of Fortetropin than circulating serum myostatin (13,14). Despite these challenges, myostatin remains an important biomarker for dogs, both as a therapeutic target and potentially in further characterizing muscle atrophy and muscle wasting secondary to sarcopenia and cachexia in dogs (2,11,13).…”

Section: Discussionmentioning

confidence: 99%

“…Objective measures such as thigh circumference, total pressure index, and protein synthesis may provide a better assessment of the effect of Fortetropin than circulating serum myostatin (13,14). Despite these challenges, myostatin remains an important biomarker for dogs, both as a therapeutic target and potentially in further characterizing muscle atrophy and muscle wasting secondary to sarcopenia and cachexia in dogs (2,11,13).…”

Section: Discussionmentioning

confidence: 99%

“…The White et al study showed stable serum myostatin concentrations in dogs receiving daily Fortetropin supplementation for 12 weeks following a tibial plateau leveling osteotomy (TPLO). Dogs in the placebo group of this study experienced a significant rise in serum myostatin as well as a significant reduction in thigh circumference (13). Based on the evidence in this early literature, Fortetropin has potential to be an important supplement in dogs for the treatment or prevention of muscle atrophy from disuse, injury, sarcopenia, and cachexia.…”

Section: Introductionmentioning

confidence: 92%

“…Fortetropin, a proteo-lipid bioactive compound, is made from non-thermal pasteurized fertilized egg yolk (13). The exact mechanism of action of Fortetropin on myostatin has not been completely elucidated; however, early research suggests that it works through upregulation of the muscle hypertrophy pathway mTOR and decreasing markers for protein break down (4).…”

Section: Introductionmentioning

confidence: 99%

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In a Randomized, Placebo-Controlled Cross-Over Study, Administration of 6 and 12 G Fortetropin® Does Not Reduce Serum Myostatin in Healthy Adult Dogs Over 72-Hours

Britt

Alvarez

Lamb³

2021

Front. Vet. Sci.

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Objective: To evaluate the effect of a single administration of 6 and 12 g of Fortetropin compared to placebo on serum myostatin in healthy, adult dogs over a 72-h period.Methods: Prospective, placebo-controlled, randomized, double-blind, crossover study. Ten hospital-employee-owned healthy adult dogs aged 2 to 8 years old were enrolled in the study. Blood samples were collected prior to and then 12-, 24-, 36-, 48-, and 72-h following administration of the test agent (6 and 12 g) or placebo. Serum samples were processed according to manufacturer's guidelines for canine serum using GDF-8/Myostatin Quantikine ELISA kit (R&D Systems). Analysis-of-variance (ANOVA) analyses were carried out where P < 0.05 was deemed significant.Results: Mean serum myostatin was not significantly lower in treatment groups of either low or high dose compared to placebo at any time point. Baseline mean serum myostatin in low and high dose treatment groups was 29,481 (SD = 5,224) and 32,214 pg/mL (SD = 7,353), respectively. Placebo group low and high dose baseline mean serum myostatin was 30,247 (SD = 5,875) and 28,512 (SD = 5,028).Conclusion: The results of this study indicate that administration of single 6 or 12 g dose of Fortetropin does not reduce serum myostatin in healthy adult dogs over a 72-h period.Clinical Importance: Oral supplements, like Fortetropin, require further studies to determine the efficacy and bioavailability in order to guide clinical use in dogs.

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Section: Discussioncontrasting

confidence: 98%