Treatment of Bowen's Disease with Topical 5% Imiquimod Cream: Retrospective Study

Abstract

Topical 5% imiquimod cream appears to be clinically beneficial in the treatment of Bowen's disease and should be considered as a treatment option.

Treatment of Squamous Cell Carcinoma In Situ: A Review

“…The largest study available evaluated 49 patients and reported a clearance rate of 86% (42/49) after a once‐daily regimen for a mean of 9 weeks, with no recurrences after an average of 19 months of follow‐up 54 . Two smaller studies each used a regimen of once‐daily application for 16 weeks with somewhat similar results.…”

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

“…51 Another study from Brazil reported that only 57% of patients (four of seven) with SCC in situ, without any significant comorbidities such as immunosuppression, cleared following a mean of 6Á1 weeks of treatment. 52 Single cases or small case series suggest that different regimens such as cyclical treatment 53 might be useful, and also that imiquimod might be effective for large facial lesions.…”

Long-term Functional and Quality of Life Outcomes of Patients After Repair of Large Perianal Skin Defects for Paget’s and Bowen’s Disease

“…It has been shown to be effective in treating PD of the scrotum 28,35 , vulva 36 , perianal region 35,37 , thigh 38 , and suprapubic region.39 Several prospective and retrospective studies have reported the efficacy of imiquimod and 5-FU in treating BD. 29,31,32,40 Based upon these promising results, several authors 30,37,40 have suggested that pharmacologic therapies be considered as an alternative to the surgical treatment of PD and BD. Results from our study support this contention by demonstrating the adverse impact of surgery on the long-term function of patients.…”