Treatment of Squamous Cell Carcinoma In Situ: A Review

Shimizu, Ikue; Cruz, Antonio P.; Chang, Kyung Hee; Dufresne, Raymond G.

doi:10.1111/j.1524-4725.2011.02088.x

Cited by 59 publications

(67 citation statements)

References 124 publications

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“…Clinical clearance rates of 76.1-98% and recurrence rates of 10.5-31% reported in the literature are comparable to our clinical clearance (78.6%) and recurrence rates (12.2%) [7,13,14,15,16]. The outcome of PDT is variable and in some cases less successful compared to other treatment modalities such as surgical excision.…”

Section: Discussionsupporting

confidence: 82%

“…Our data showed a significantly higher clinical clearance and lower recurrence rate in younger BD patients. To our knowledge this has not been previously described in the literature [7,13,19]. Advanced age is associated with a decreased function of the immune system [20,21].…”

Section: Discussionmentioning

confidence: 74%

“…The outcome of PDT is variable and in some cases less successful compared to other treatment modalities such as surgical excision. Already known from the literature was that large BD lesions, multifocal BD and BD on body sites associated with poor wound healing are especially suitable for PDT treatment, although lower success rates can be expected on the lower extremities [4,5,7,13,17,18]. In our study we looked for different clinical and histological factors influencing PDT outcome in BD.…”

Section: Discussionmentioning

confidence: 99%

“…Calzavara-Pinton et al [19] studied MAL-PDT for invasive and in situ SCC and found that cell atypia (Broder's cell atypia) was a significant risk factor for incomplete response after 3 months and recurrence within 2 years in multivariate analysis. Therefore, in our opinion surgical excision, with a recurrence rate of 4.6-19.4%, is to be preferred over PDT in BD with severe cell atypia [7,13]. …”

Section: Discussionmentioning

confidence: 99%

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Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

et al. 2014

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Background: In Bowen's disease (BD) there is no consensus on optimal treatment. Photodynamic therapy (PDT) is an effective non-invasive treatment modality for BD with excellent cosmetic results. Objective: This retrospective study examines whether clinical and histological features of BD impact PDT response. Methods: Patients with previously untreated BD from 2002 until 2007 were identified at the Maastricht University Medical Centre. Patients treated with PDT were included. All histological slides were re-examined. Results: During the study period 98 tumours were treated with PDT. In univariate analysis severe atypia and higher age were associated with decreased probability of clinical clearance. Higher age was also associated with an increased risk of recurrence. In multivariate analysis severe atypia remained the only independent risk factor for therapy failure. Conclusion: In patients with BD, severe atypia and higher age are associated with an increased risk of treatment failure after PDT.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

et al. 2014

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“…The annual incidence in the UK is 15/100,000 and 14.9-27.8/100,000 in North American populations (3,4). The peak incidence is in the seventies (5).…”

mentioning

confidence: 99%

Bowen’s Disease: A Six-year Retrospective Study of Treatment with Emphasis on Resection Margins

Westers-Attema¹,

Heijkant²,

Lohman³

et al. 2014

Acta Derm Venerol

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Bowen's disease is an in situ squamous cell carcinoma of the skin with various treatment modalities available. A major advantage of surgical excision is the opportunity to histologically examine the resection margins. There is no consensus about the most appropriate margin. This retrospective study evaluates the clearance rates achieved by excision with a 5 mm margin and estimates how that might change after fictitiously reducing the resection margin by 1 or 2 mm. Patients with histologically confirmed Bowen's disease were selected at the Maastricht University Medical Centre from 2002 until 2007. Surgical margins and complete excision rates were evaluated and histological slides were re-examined. To our knowledge this is the first study investigating the safety margin for Bowen's disease. As Bowen's disease is not an invasive disease, minimisation of healthy tissue excision is desirable. Our data show that a hypothetical reduction of the safety margin from 5 mm to 4 or 3 mm decreases the complete excision rate from 94.4% to 87% and 74.1%, respectively.

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Actinic Keratosis and Bowen's Disease

Gupta

Bowen

Cooper

et al. 2014

Evidence‐Based Dermatology

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Treatment of Squamous Cell Carcinoma In Situ: A Review

Abstract: There are many methods available to treat SCCIS. Physicians should consider each patient's situation while keeping in mind that treatment protocols have not been fully defined for most options. The authors have indicated no significant interest with commercial supporters.

Cited by 59 publications

References 124 publications

Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

Bowen’s Disease: A Six-year Retrospective Study of Treatment with Emphasis on Resection Margins

Actinic Keratosis and Bowen's Disease

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