Treatment of Bone Defects — Allogenic Platelet Gel and Autologous Bone Technique

Smrke, Dragica; Rožman, Primož; Veselko, Matjaž; Gubina, Borut

doi:10.5772/55987

Cited by 20 publications

(28 citation statements)

References 52 publications

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“…Autologous bone graft is being used as a gold standard of GTR, with disadvantage that patient has to undergo additional operations and having risk for all the accompanied complications.1 Therefore alternative graft materials are being investigated. Materials that are in use are heterologous, xenografts, autologous and allogeneic [3,4,12]. Which type of graft we decide to use depends on the reason for its use, therefore clinical picture, age and mobility of the patient [13].…”

Section: Principles Of Tissue Guided Regeneration and Its Use In Surgerymentioning

confidence: 99%

“…Out of heterologous material, the most investigated is bovine, but also porcine bone grafts are in use. The aim of tissue engineering is to provide better materials and its efficiency with less side effects [14,15] The essential idea of this therapy was to combine the healing capacities of platelet-derived growth factors and osteogenic stem cells and the modeling capacity of the gel [3,6,10,14] …”

Section: Principles Of Tissue Guided Regeneration and Its Use In Surgerymentioning

confidence: 99%

“…Therefore surgery plays a major role in the treatment process. There are many novelties being used in surgical treatment, such as musculoskeletal tumour surgery, intramuscular flap and GTR [1,3,4]. The treatment approach must be multidisciplinary with surgical basis [4,5].…”

Section: Multidisciplinary Treatment Approach To Osteomyelitis and Womentioning

confidence: 99%

“…Deficit of soft tissues is often solved by methods of reconstructive surgery (flap) and filling of large bone defect using spongioplastics, drainage or antibiotic beads. Another possible way of reconstructing the bone deficit is using GTR which uses the allogeneic platelet gel, autologous cancellous bone graft and resorptive collagen membrane, the basic idea of which is to heal the tissue with potential growth factors derived from platelets and osteogenic progenitor cells [3,4,[6][7][8].…”

Section: Multidisciplinary Treatment Approach To Osteomyelitis and Womentioning

confidence: 99%

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Tissue Guided Regeneration with Platelet Rich Plasma and Resorptive Collagen Membrane in Case of Chronic Osteomyelitis of Tibia

Kos¹

2014

Clin Res Foot Ankle

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Background: Chronic osteomyelitis is a serious and difficult complication in open fractures, occurring in about 20% of cases. Treatment approach must be multidisciplinary with surgical basis. At the end of the classical eradication of the infection, there is often a large bone defect. Guided tissue regeneration (GTR) with allogeneic platelet gel, autologous cancellous bone graft and resorptive collagen membrane is one of the possibilities how to bridge bone defect.

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Section: Principles Of Tissue Guided Regeneration and Its Use In Surgerymentioning

confidence: 99%

Section: Principles Of Tissue Guided Regeneration and Its Use In Surgerymentioning

confidence: 99%

Section: Multidisciplinary Treatment Approach To Osteomyelitis and Womentioning

confidence: 99%

Section: Multidisciplinary Treatment Approach To Osteomyelitis and Womentioning

confidence: 99%

See 2 more Smart Citations

Tissue Guided Regeneration with Platelet Rich Plasma and Resorptive Collagen Membrane in Case of Chronic Osteomyelitis of Tibia

Kos¹

2014

Clin Res Foot Ankle

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“…Bone serves as a structural scaffold where the muscles attach and has a role in their contraction, supports vital organs including the brain and spinal cord, is a major source of calcium and phosphate, and provides a microenvironment suitable for hematopoietic cell differentiation [1]. Pathological conditions that damage vital bone components can cause a decrease in at least one of the functions of the bone and can cause bone defects [2]. In small bone defects, the bone can regenerate spontaneously or with minimal intervention.…”

Section: Introductionmentioning

confidence: 99%

ALP gene expression in cDNA samples from bone tissue engineering using a HA/TCP/Chitosan scaffold

Stephanie

Katarina

Amir

et al. 2017

J. Phys.: Conf. Ser.

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Abstract. This study examined the potential use of hydroxyapatite (HA)/tricalcium phosphate (TCP)/Chitosan as a bone tissue engineering scaffold. The potential for using HA/TCP/chitosan as a scaffold was analyzed by measuring expression of the ALP osteogenic gene in cDNA from bone biopsies from four Macaque nemestrina. Experimental conditions included control (untreated), treatment with HA/TCP 70:30, HA/TCP 50:50, and HA/TCP/chitosan. cDNA samples were measured quantitively with Real-Time PCR (qPCR) and semi-quantitively by gel electrophoresis. There were no significant differences in ALP gene expression between treatment subjects after two weeks, but the HA/TCP/chitosan treatment gave the highest level of expression after four weeks. The scaffold using the HA/TCP/chitosan combination induced a higher level of expression of the osteogenic gene ALP than did scaffold without chitosan.

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Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects

Anandhapadman¹,

Venkateswaran²,

Jayaraman³

et al. 2022

Biotechnology Progress

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The conventional methods of using autografts and allografts for repairing defects in bone, the osteochondral bone, and the cartilage tissue have many disadvantages, like donor site morbidity and shortage of donors. Moreover, only 30% of the implanted grafts are shown to be successful in treating the defects. Hence, exploring alternative techniques such as tissue engineering to treat bone tissue associated defects is promising as it eliminates the above‐mentioned limitations. To enhance the mechanical and biological properties of the tissue engineered product, it is essential to fabricate the scaffold used in tissue engineering by the combination of various biomaterials. Three‐dimensional (3D) printing, with its ability to print composite materials and with complex geometry seems to have a huge potential in scaffold fabrication technique for engineering bone associated tissues. This review summarizes the recent applications and future perspectives of 3D printing technologies in the fabrication of composite scaffolds used in bone, osteochondral, and cartilage tissue engineering. Key developments in the field of 3D printing technologies involves the incorporation of various biomaterials and cells in printing composite scaffolds mimicking physiologically relevant complex geometry and gradient porosity. Much recently, the emerging trend of printing smart scaffolds which can respond to external stimulus such as temperature, pH and magnetic field, known as 4D printing is gaining immense popularity and can be considered as the future of 3D printing applications in the field of tissue engineering.

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Treatment of Bone Defects — Allogenic Platelet Gel and Autologous Bone Technique

Cited by 20 publications

References 52 publications

Tissue Guided Regeneration with Platelet Rich Plasma and Resorptive Collagen Membrane in Case of Chronic Osteomyelitis of Tibia

Tissue Guided Regeneration with Platelet Rich Plasma and Resorptive Collagen Membrane in Case of Chronic Osteomyelitis of Tibia

ALP gene expression in cDNA samples from bone tissue engineering using a HA/TCP/Chitosan scaffold

Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects

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