Treatment of asthma in children with triamcinolone acetonide aerosol

Sly, R. Michael; Imseis, M; Frazer, Maria E.; Joseph, Franklin

doi:10.1016/0091-6749(78)90082-9

Cited by 27 publications

(4 citation statements)

References 21 publications

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“…No significant effect on the HPAA was observed with FP (100–200 μg/day) ( 80) in a long‐term study performed on asthmatic children. High doses of FLU and TA (>1000 μg/day) appeared to have no effect on free urinary cortisol ( 81, 82). FP and BUD 400 μg/day for 4 weeks did not affect the plasma cortisol levels in asthmatic children, although FP showed a slightly more pronounced effect ( 83).…”

Section: Systemic Side‐effectsmentioning

confidence: 89%

Inhaled and nasal corticosteroids: safety aspects*

Passalacqua¹,

Albano²,

Canonica³

et al. 2000

Allergy

101

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Section: Systemic Side‐effectsmentioning

confidence: 89%

Inhaled and nasal corticosteroids: safety aspects*

Passalacqua¹,

Albano²,

Canonica³

et al. 2000

Allergy

101

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“…63,66 In studies of children, inhaled flunisolide and triamcinolone, given in doses of up to 1000 m g per day, had no effect on 24-hour urinary cortisol excretion. 67,68 Beclomethasone, given to children in doses of 800 m g or less, also left urinary cortisol excretion unchanged. 69,70 In studies in which plasma cortisol was measured at frequent intervals, there was a small but significant reduction in nocturnal values when beclomethasone and budesonide were inhaled in doses as low as 400 m g per day.…”

Section: Suppression Of Hypothalamic-pituitary-adrenal Functionmentioning

confidence: 99%

Inhaled Glucocorticoids for Asthma

Barnes¹

1995

N Engl J Med

584

288

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“…Further, treatment with 0.5mg of flunisolide aerosol twice a day for periods of 2 months (Meltzer et al 1982;Piacentini et al 1990) or 12 weeks (Shapiro et al 1981) was not associated with any evidence of adrenal suppression. No significant changes in plasma cortisol levels were observed in adults treated with triamcinolone in doses of 1600/Lg daily (half a dose is available at the mouthpiece) for up to 1 year (Bernstein et al 1982) or in children with a dosage of 400 /Lyday for 8 weeks (Sly et al 1978).…”

Section: Hypothalamic-pituitary-adrenal (Hpa) Axis Suppressionmentioning

confidence: 96%

Inhaled Corticosteroids in Children

Boner

Piacentini

1993

Drug Safety

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Inhaled corticosteroids are effective for the treatment of asthma. Because of the appreciation of the importance of airway inflammation in the pathogenesis of the disease, these drugs are being used more frequently not only in severe but also in moderate asthma. Treatment rarely has to be stopped because of topical adverse effects since oropharyngeal candidiasis and dysphonia are uncommon in children. However, paediatricians need to remain alert for the possibility of systemic adverse effects. With sensitive techniques, dose-dependent adrenal suppression has been documented in children treated with inhaled steroids but generally this effect has no clinical relevance. Although suppression of short term growth velocity has been reported, long term studies have shown that when growth impairment occurs in a child with asthma it is more likely to reflect poor asthma control than the administration of inhaled corticosteroids. Calcium supplementation may be necessary in children with asthma treated with inhaled steroids since this treatment may cause reduction in osteocalcin, a marker of osteoblast activity and bone formation. Other systemic adverse effects have been reported in case reports. The use of a large spacer device has been shown to reduce the incidence of both topical and systemic adverse effects from inhaled steroids and their use should be encouraged. In any child with asthma who really needs inhaled steroids, the lowest dose possible should be prescribed; however, the mistake of prescribing doses too low to be therapeutically effective should be avoided.

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Treatment of asthma in children with triamcinolone acetonide aerosol

Cited by 27 publications

References 21 publications

Inhaled and nasal corticosteroids: safety aspects*

Inhaled and nasal corticosteroids: safety aspects*

Inhaled Glucocorticoids for Asthma

Inhaled Corticosteroids in Children

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