Treatment of anticancer drugs in hospital and wastewater effluents using nanofiltration

Cristóvão, M.B.; Torrejais, J.; Janssens, Raphaël; Luis, Patricia; Dubey, Kashyap Kumar; Mandal, Mrinal Kanti; Bronze, Maria Rosário; Crespo, João G.; Pereira, Vanessa J.

doi:10.1016/j.seppur.2019.05.016

Cited by 54 publications

(28 citation statements)

References 52 publications

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“…Based on previously optimized conditions, the pilot unit was operated at a controlled pressure difference of 6 bar and an average recovery rate of 70% [ 26 ]. During the 24 h of in situ experiments, the permeance did not change much with an average normalized value (20 °C) of 2.8 L·h −1 ·m −2 ·bar −1 and a coefficient of variation of 6.3%.…”

Section: Resultsmentioning

confidence: 99%

“…The operation of the pilot unit has been optimized in a previous study conducted with the same effluent and several assays were conducted under controlled permeate flux (12.7 L·m −2 ·h −1 , 15.2·L·m −2 ·h −1 , 19.0 L·m −2 ·h −1 and 25.3 L·m −2 ·h −1 ) or controlled transmembrane pressure conditions (5 bar and 6 bar) and different recovery rates (feed flow of water converted into treated flow of water (permeate); approximately 20%, 30%, 40%, 70% and 80%) to determine the operating conditions that would minimize fouling resistance, would maximize the production of treated water and rejection of anticancer compounds [ 26 ]. The best operating conditions for this wastewater effluent were found at a controlled pressure difference of 6 bar and using a recovery rate of approximately 70%.…”

Section: Methodsmentioning

confidence: 99%

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Occurrence of Antibiotics, Antibiotic Resistance Genes and Viral Genomes in Wastewater Effluents and Their Treatment by a Pilot Scale Nanofiltration Unit

et al. 2020

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Broad-spectrum fluoroquinolone antibiotics (ciprofloxacin and levofloxacin), carbapenem and fluoroquinolone resistance genes, as well as viral genomes, were detected in grab samples of wastewater effluents. Passive samplers, which are simpler and easier to use and provide information about the concentrations and combination of contaminants present in a certain fluid matrix over time, proved to be extremely promising devices to monitor the presence of the target antibiotics in wastewater effluents. Nanofiltration was tested with a pilot-scale unit installed at a domestic wastewater treatment facility, using a Desal 5DK membrane operated at a constant transmembrane pressure of 6 bar and 70% recovery rate. In a 24 h experimental assay, the variation of the membrane permeance was low (6.3%). High rejections of the target contaminants from the wastewater effluent were obtained by the pilot-scale treatment. Hence, nanofiltration using the Desal 5DK membrane is considered to be a promising treatment to cope with chemical and biological contaminants present in wastewater effluents.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Occurrence of Antibiotics, Antibiotic Resistance Genes and Viral Genomes in Wastewater Effluents and Their Treatment by a Pilot Scale Nanofiltration Unit

et al. 2020

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“…An inherent consequence of the increase in cancer incidence is the constant search for new, effective solutions, the increase in the consumption of anticancer drugs (ADs) [ 3 , 5 ], and the risk of introducing more of these substances into natural ecosystems. These drugs, due to their non-specific mode of action, as well as mutagenic, carcinogenic, cyto- and genotoxic properties, disrupting the functioning of the endocrine system in eukaryotic cells, should be given greater and special attention because information on their potential risk to both humans and the environment is still limited [ 3 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Insight into the Sorption of 5-Fluorouracil and Methotrexate onto Soil–pH, Ionic Strength, and Co-Contaminant Influence

et al. 2021

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Nowadays anticancer drugs (ADs), like other pharmaceuticals, are recognized as new emerging pollutants, meaning that they are not commonly monitored in the environment; however, they have great potential to enter the environment and cause adverse effects there. The current scientific literature highlights the problem of their presence in the aquatic environment by publishing more and more results on their analytics and ecotoxicological evaluation. In order to properly assess the risk associated with the presence of ADs in the environment, it is also necessary to investigate the processes that are important in understanding the environmental fate of these compounds. However, the state of knowledge on mobility of ADs in the environment is still very limited. Therefore, the main aim of our study was to investigate the sorption potential of two anticancer drugs, 5-fluorouracil (5-FU) and methotrexate (MTX), onto different soils. Special attention was paid to the determination of the influence of pH and ionic strength as well as presence of co-contaminants (cadmium (Cd2+) and another pharmaceutical—metoprolol (MET)) on the sorption of 5-FU and MTX onto soil. The obtained distribution coefficient values (Kd) ranged from 2.52 to 6.36 L·kg−1 and from 6.79 to 12.94 L·kg−1 for 5-FU and MTX, respectively. Investigated compounds may be classified as slightly or low mobile in the soil matrix (depending on soil). 5-FU may be recognized as more mobile in comparison to MET. It was proved that presence of other soil contaminants may strongly influence their mobility in soil structures. The investigated co-contaminant (MET) caused around 25-fold increased sorption of 5-FU, whereas diminished sorption of MTX. Moreover, the influence of environmental conditions such as pH and ionic strength on their sorption has been clearly demonstrated.

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“…Nevertheless, the available data is quite diversified in the terms of the threat and risk they might pose. On one hand, their concentrations in hospital effluents (up to hundreds μg L −1 (Cristóvão et al 2019;Santana-Viera et al 2020)) are alarmingly high as well as their presence in wastewater effluents (Hilton and Thomas 2003;Olalla et al 2018;Santana-Viera et al 2019) is concerning. On the other hand, the concentrations in natural waters are on the level of ng L −1 (Azuma 2018;Ferrando-Climent et al 2014;Kosjek and Heath 2011), if the anticancer drugs are detected at all (Santos et al 2018;Ternes 1998).…”

Section: Introductionmentioning

confidence: 99%

Hydrolytic stability of anticancer drugs and one metabolite in the aquatic environment

Toński

Dołżonek

Stepnowski

et al. 2021

Environ Sci Pollut Res

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Due to the genotoxic, carcinogenic and teratogenic mechanism of action, anticancer drugs are highly hazardous compounds. Their occurrence, fate, and effects in the environment have not been systematically studied as compared to other medicaments. Therefore, reliable data, including their stability and persistency, is required in order to assess it. Taking into account, that hydrolysis is one of the most important factors regarding stability of chemicals in water, the aim of our study was to investigate the hydrolytic stability of five commonly used anticancer drugs (ifosfamide, cyclophosphamide, 5-fluorouracil, imatinib, and methotrexate) and one metabolite (7-hydroxymethotrexate), as the systematized and coherent data available is limited. The hydrolysis studies have been prepared according to the OECD 111 procedure to obtain standardized and comparable results. The preliminary tests at pH 4, 7, and 9 and 50 °C show that only cyclophosphamide and ifosfamide are unstable, whereas the estimated t1/2 at 25 °C is >1 year for other investigated compounds. Moreover, much more detailed experiments were performed and indicate that at environmentally relevant temperatures, cyclophosphamide, and ifosfamide would be quite persistent in the terms of hydrolytic stability. Moreover, the preliminary investigation on the hydrolysis products was performed.

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Treatment of anticancer drugs in hospital and wastewater effluents using nanofiltration

Cited by 54 publications

References 52 publications

Occurrence of Antibiotics, Antibiotic Resistance Genes and Viral Genomes in Wastewater Effluents and Their Treatment by a Pilot Scale Nanofiltration Unit

Occurrence of Antibiotics, Antibiotic Resistance Genes and Viral Genomes in Wastewater Effluents and Their Treatment by a Pilot Scale Nanofiltration Unit

Insight into the Sorption of 5-Fluorouracil and Methotrexate onto Soil–pH, Ionic Strength, and Co-Contaminant Influence

Hydrolytic stability of anticancer drugs and one metabolite in the aquatic environment

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