Treatment of an early failing implant by guided bone regeneration using resorbable collagen membrane and bioactive glass

Talreja, Prakash S; Gayathri, GV; Mehta, Dhoom Singh

doi:10.4103/0972-124x.107490

Cited by 21 publications

(22 citation statements)

References 11 publications

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“…Conventional protocols for guided bone regeneration (GBR) involve placement of a bone substitute material like hydroxyapatite or b-tricalcium phosphate (b-TCP) at the bone defect site and covering it with a barrier membrane followed by a healing period ranging from 6 to 10 months [1][2][3]. Based on histological findings in animal models, GBR using b-TCP promotes formation of new bone in osseous defect sites as early as 12 weeks [3,4].…”

Section: Introductionmentioning

confidence: 99%

Guided bone regeneration in standardized calvarial defects using beta-tricalcium phosphate and collagen membrane: a real-time in vivo micro-computed tomographic experiment in rats

et al. 2015

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Guided bone regeneration (GBR) procedures using graft materials have been used for reconstruction of osseous defects. The aim of the present in vivo micro-computed tomographic (µCT) and histologic study was to assess in real time the bone regeneration at GBR sites in standardized experimental calvarial defects (diameter 3.3 mm) using β-tricalcium phosphate (β-TCP) with and without collagen membrane (CM). A single full-thickness calvarial defect was created on the left parietal bone in young female Wistar albino rats (n = 30) weighing approximately 300 g and aged about 6 weeks. The animals were randomly divided into three groups for treatment, based on calvarial defect filling material: (1) control group (n = 10); (2) β-TCP + CM group (n = 10); (3) β-TCP group (n = 10). Real-time in vivo µCT analyses were performed immediately after surgery and at 2, 4, 6 and 10 weeks to determine the volume and mineral density of the newly formed bone (BVNFB, MDNFB) and remaining β-TCP particles (VRBP, MDRBP). The animals were killed at 10 weeks and calvarial specimens were evaluated histologically. In the control group, MDNFB increased significantly at 6 weeks (0.32 ± 0.002 g/mm(3), P < 0.01) compared to that at baseline. In β-TCP + CM group, BVNFB (1.10 ± 0.12 mm(3), P < 0.01) and MDNFB (0.13 ± 0.02 g/mm(3), P < 0.01) significantly increased at the 4th week than baseline. In the β-TCP group, BVNFB (1.13 ± 0.12 mm(3), P < 0.01) and MDNFB (0.14 ± 0.01 g/mm(3), P < 0.01) significantly increased at 6 weeks compared to that at baseline. Significant reduction in VRBP was neither seen in the β-TCP + CM group nor in the β-TCP group. While in the β-TCP + CM group MDRBP was reduced significantly at 6 weeks (0.44 ± 0.9 g/mm(3), P < 0.01) from baseline (0.98 ± 0.03 g/mm(3)), similar significant reduction in MDRBP from baseline (0.92 ± 0.07 g/mm(3)) was seen only at 10 weeks (0.45 ± 0.06 g/mm(3), P < 0.05) in the β-TCP group. Histologic findings at 10 weeks revealed greater amount of NFB with osteocytes in the matrix, in the β-TCP + CM group than in the β-TCP group. Biomechanical assessment of NFB for hardness (H) and elastic modulus (E) revealed significantly higher values for the β-TCP + CM group (H = 612.6 ± 4.28 Mpa; E = 13.57 ± 0.07 Gpa) when compared to those of the control (H = 192.1 ± 4.93 Mpa; E = 6.76 ± 0.04 Gpa) and the β-TCP groups (H = 241.9 ± 6.29 Mpa; E = 4.34 ± 0.06 Gpa). In conclusion, based on real-time assessment, NFB is formed in calvarial defects as early as 4 weeks following GBR with β-TCP + CM as compared to 6 weeks when β-TCP alone was used.

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Section: Introductionmentioning

confidence: 99%

Guided bone regeneration in standardized calvarial defects using beta-tricalcium phosphate and collagen membrane: a real-time in vivo micro-computed tomographic experiment in rats

et al. 2015

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“…The permittivity was calculated using Equation (2). [30][31][32][33] where C p and R p represent the measured capacitance and resistance, d is the sample thickness, A the electrode area and ɛ 0 the permittivity of the empty space (8.8542 × 10 −12 F/m).…”

Section: Structural and Morphological Characterizationmentioning

confidence: 99%

Nontoxic glasses: Preparation, structural, electrical and biological properties

Gavinho

Prezas

Ramos

et al. 2019

Int J Applied Ceramic Tech

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Bacterial infections affect about 1 in 5 patients who receive a dental implant within 5 years of surgery. To avoid the implant rejection it is necessary for the development of innovative biomaterials, with addition or substitution of the ions, for implant coatings that promote a strong bond with the new host bone and antibacterial action. The objective of this work was to synthesize a bioactive glass with different silver concentrations to evaluate their antibacterial performance. The glasses were synthesized with up to 2% silver content by melt‐quenching. Structural, morphological, biological, and electrical properties of all samples were studied. The biological behavior was evaluated through cytotoxicity tests and antibacterial activity. The structural analysis shows that the introduction of silver do not promote significant changes, not altering the advantageous properties of the bioglass of the bioglass. It was verified that the glasses with a silver content from 0.5% to 2%, completely prevented the growth of both Staphylococcus aureus and Escherichia coli while being nontoxic toward mammalian cells. Therefore, these bioglasses are promising materials to be used in the production of dental implants with antimicrobial activity.

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“…Marchetti et al 65) described this area of attachment as "a biological seal", since it isolates the oral cavity from bone and hence greatly affects the success of dental implants. Related to oral implants, peri-implantitis has been discussed extensively 34) . B-G has shown to be active against supra-and sub-gingival bacteria 9) , further underlining its potential benefits as part of an implanted device by means of metal surface coating.…”

Section: Metal Surface Biofunctionalization: Coating Materials For Denmentioning

confidence: 99%

“…There has been a number of clinical studies that have demonstrated consistent results in a variety of alternative treatments including the surgical modification/reduction (elevation) of the maxillary sinus 30) , the regeneration of interproximal bone defects in periodontal therapies 31) , periapical application during endodontic microsurgery 32) (Fig. 3), management of cystic defects 33) , as well as reconstructive procedures for treating peri-implantitis 34) . All these clinical applications have one thing in common -the proven efficacy and effectiveness to bond with hard tissue and enhance its growth due to the osteoconductive and osteostimulatory properties of the glass.…”

Section: Clinical Applicationsmentioning

confidence: 99%