Treatment of Advanced Non-small Cell Lung Cancer with the Combination of Systemic Chemotherapy and Adoptive Immunotherapy.

Ito, Kenichi; Goto, Makoto; Mizusawa, Akio; Miyao, Hiromi; Chou, Takaaki; Arakawa, Masaaki

doi:10.2482/haigan.32.81

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Effect O F Systemic Combination Therapy1

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1994

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“…Although she died of dissemination of cancer after 14 months, the treatment was effective for her multiple bone metastases. The treatment and the clinical course of case 6 have been reported in detail [7]. Based on the treatment experience in case 6, we next performed systemic combi nation therapy as the first-line treatment.…”

Section: Effect O F Systemic Combination Therapymentioning

confidence: 99%

Treatment of Advanced Primary Lung Cancer Associated with Malignant Pleural Effusion by the Combination of Immunotherapy and Chemotherapy

Miyao¹,

Chou²,

Ito³

et al. 1994

Oncology

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Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were marginal, and the protocol was well-tolerated and feasible. Furthermore, 4 cases were treated with the combination of systemic chemotherapy and adoptive immunotherapy. Of these, 3 cases responded well to the therapy and have shown a complete response for more than 20 months, indicating that adoptive immunotherapy together with chemotherapy might be a beneficial treatment for advanced lung cancer patients.

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Section: Effect O F Systemic Combination Therapymentioning

confidence: 99%