Treatment of Advanced Primary Lung Cancer Associated with Malignant Pleural Effusion by the Combination of Immunotherapy and Chemotherapy

Abstract

Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were marginal, and the protocol was well-tolerated and feasible. Furthermore, 4 cases were treated with the combination of systemic chemotherapy and adoptive immunotherapy. Of these, 3 cases responded well to the therapy and have shown a complete response for more than 20 months, indicating that adoptive immunotherapy together with chemotherapy might be a beneficial treatment for advanced lung cancer patients.

Effector, memory and naïve CD8+ T cells in peripheral blood and pleural effusion from lung adenocarcinoma patients

“…Some studies have shown that PEMC exhibit several functional defects [8,9]. In addition, previous clinical trials evaluating specific and non-specific immune stimulation for the treatment of lung cancer associated to pleural effusion have shown poor results [10,11].…”

Advanced Combinatorial Radioimmunogenetic Therapy for Cancer

“…Hemato and hepato abnormalities were related to the association of pro drug and can be resolved spontaneously. GU and GI are common radiation related side effects [15][16][17][18][19][20][21].…”