“…Phenylbutazone showed a prolonged significant suppression of the permeability response from 0 to 2 min to 3 h. This drug is reported to antagonize histamine, 5-HT, bradykinin (Starr & West, 1967;Pelczarcska & Gieldanowski, 1970) and prostaglandins (Flower, 1974), in mammals. However, despite the reported antagonistic action of phenylbutazone against bradykinin, participation of bradykinin in the mediation of avian inflammatory response seems unlikely.…”