Treatment of Addison's Disease With Desoxy-Corticosterone Acetate, a Synthetic Adrenal Cortical Hormone (Preliminary Report) 1

Evidence That Renal Sodium Excretion by Normal Human Subjects Is Regulated by Adrenal Cortical Activity 1

“…It is noted from this figure that the decreased potassium excretion that followed each period of sodium administration can only partially be accounted for by the decreased catabolism of protein that occurred at that time. Knowing that desoxycorticosterone, the salt-and-water hormone par excellence, produces an increased renal excretion of potassium (37,38) while patients with Addison's disease and adrenalectomized animals have a decreased ability to excrete potassium (1,39), this observed drop in potassium excretion is taken to be, at least in part, the result of a de-.creased salt-and-water hormone activity occurring at this time when there is a large renal sodium excretion. Unfortunately, the serum potassium concentration was not determined immediately following the days of lowest urinary potassium excretion to ascertain whether or not an elevation of serum potassium occurred as a result of this decreased renal potassium excretion.…”

Influence of the Adrenal Cortex on Body Water Distribution and Renal Function1

“…The suggestion that this hemoconcentration might be attributed to a decrease in plasma volume (3,4) was later confirmed by direct measurement (4)(5)(6)(7)(8), and by the circumstance that normal plasma volume was restored with adequate desoxycorticosterone therapy (6)(7)(8)(9).…”

The Prevention of Acth-Induced Sodium Retention by the Use of Potassium Salts: A Quantitative Study

“…Administration of large doses of either corticotropin (ACTH) (1) or tie adrenal steroids (2)(3)(4)(5) to human subjects ordinarily results in an initial phase of sodium retention which is often accompanied by increased excretion of potassium in the urine and by a decrease in intracellular potassium (6). In order to minimize potassium depletion, it has become common practice to add supplements of potassium salts to the diets of patients receiving large doses of ACTH or cortisone.…”