Influence of the Adrenal Cortex on Body Water Distribution and Renal Function1

Asymptomatic Hyponatremia in Pulmonary Tuberculosis 1

“…Although there is as yet no primary and independent evidence that such a state of chronically altered cellular osmolarity does occur, acute alterations in cellular osmolarity have been observed. This phenomenon has been suggested by several groups to explain certain results in their investigations (23)(24)(25)(26)(27).…”

The Action of Cortisone and Desoxycorticosterone Acetate on Glomerular Filtration Rate and Sodium and Water Exchange in the Adrenalectomized Dog

“…On 47 occasions the diuretic response to the standard water dose (supra) and the accompanying outputs of sodium and potassium were measured for three hours without determining GFR and ERPF. 4 The priming infusion consisted of hypertonic creatinine and PAH in about 60 ml. of distilled water.…”

“…In the dog, as in man, the ability to conserve sodium is impaired (1,2), there is a fall in glomerular filtration rate and renal blood flow (3)(4)(5)(6), and diuresis from water ingestion is much delayed (7,8).…”

“…Though DCA appears to act mainly on electrolyte excretion, yet, when given in larger amounts than are needed for optimal sodium balance, it may then correct the low filtration rate of adrenalectomized dogs (4,8,9). It is not clear, however, whether this last effect is mainly or wholly dependent on excessive sodium retention, for no comparable studies appear to have been made at deliberately optimal levels of sodium balance (10,11).…”

Alterations in Body Composition With Sodium Loading and Potassium Restriction in the Rat: The Total Body Sodium, Nitrogen, Magnesium and Calcium 1

“…Hypernatremia (19)(20)(21) with an increase in exchangeable sodium (21,22) is also seen following the administration of DCA to dogs. Exchangeable chloride remains normal (21).…”