Treatment of acne vulgaris with auricular acupoint pricking-bloodletting plus auricular point sticking therapy: a randomized controlled study

Song, Yajing; Xisheng, Fan; Li, Mengyun; Zhang, Jie; Geng, Jingran; Liang, Xiao; Juncha, Zhang; Xiao-qi, Zhang; Zhou, Shu-bo; Wang, Nan; Zhang, Jia-Xu; Song, Xiaodan; She, Yan-Fen

doi:10.1007/s11726-019-1112-0

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Thus, ABT and APS can reduce inflammatory infiltration at the acne site and reduce exudation, which can help reverse inflammatory deterioration. However, a between-group comparison of ABT, APS, and ABPS showed that the combination of ABT and APS did not enhance the anti-inflammatory effect, which is not consistent with our previous clinical study [ 19 ]. This may be because ABT pierces the skin, and rats scratch their ears or tear each other, which may reduce the efficacy of this intervention.…”

Section: Discussioncontrasting

confidence: 90%

“…The results also showed localized acne-like manifestations in the ear of rats such as reddening welts, swelling, and purulent discharge. We selected representative ABT and APS from our previous clinical studies with the aim of exploring their anti-inflammatory effects on acne [ 18 , 19 ]. The preliminary clarification of the mechanism of this therapy will lay the foundation for the next in-depth study of auriculotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Auriculotherapy Modulates Macrophage Polarization to Reduce Inflammatory Response in a Rat Model of Acne

Zuo

Gao

et al. 2023

Mediators of Inflammation

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Background. The inflammatory response is an important part of the pathogenesis of acne vulgaris. Auriculotherapy has been shown to have a good therapeutic effect on this disease. The aim of this study was to explore the mechanism underlying the anti-inflammatory effect of auriculotherapy in the treatment of acne vulgaris. Methods. Propionibacterium acnes was injected subcutaneously into the ears of rats to establish an animal model of acne. The auriculotherapy intervention in rats consisted of auricular bloodletting therapy (ABT), auricular point sticking (APS), or a combination of both (ABPS). The anti-inflammatory effects of auriculotherapy were evaluated by measuring changes in ear thickness, local body surface microcirculation in the ear, and serum inflammatory factors in rats. The polarization of macrophages was analyzed by flow cytometry, and the expression of TLR2/NF-κB signaling pathway in the target tissues was analyzed using western blot. Results. ABT, APS, and ABPS all reduced the erythema of ear acne, decreased microcirculation in localized ear acne, and decreased serum levels of TNF-α and IL-1β in rats. Meanwhile, the three interventions reduced M1-type macrophages and increased M2-type macrophages; only APS could reduce the expression of TLR2/NF-κB signaling pathway. Conclusion. ABT, APS, and ABPS can improve the inflammatory symptoms of acne and reduce inflammatory cytokines. APS may exert anti-inflammatory effects by altering macrophage polarization and decreasing TLR2/NF-κB expression.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Auriculotherapy Modulates Macrophage Polarization to Reduce Inflammatory Response in a Rat Model of Acne

Zuo

Gao

et al. 2023

Mediators of Inflammation

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“…Clinical effect: (1) Invalid: The symptoms of constipation were aggravated and adverse reactions occurred; (2) Valid: The constipation was improved but not smooth enough, and the stool was dry; (3) Remarkable effect: The patient had a smooth bowel movement, the symptoms of constipation disappeared, and the stool characteristics were normal [10] .…”

Section: Observation Indicatorsmentioning

confidence: 99%

Observation on the Curative Effect of Auricular Acupoint Sticking Combined with Acupoint Sticking in the Treatment of Diabetic Constipation

Wang

et al. 2022

JCNR

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The study was conducted to observe the clinical effect of acupoint and auricular point application on diabetes patients with constipation. Around 104 patients with diabetes and constipation were selected from the Hospital Shaanxi University of Chinese Medicine from February 2021 to February 2022 as the study subjects. They were divided into groups by drawing lots. The experimental group carried out the combined analysis of acupoint and auricular point application based on the treatment methods of the control group. Meanwhile, the control group carried out the traditional treatment, and the evaluation index, including the improvement of constipation and the clinical effective rate data were included in the analysis. This study showed that, the total effective number of patients, times of defecation per week, time of defecation, and interval of defecation in the experimental group were greater, compared to control group (p < 0.05). In summary, diabetes patients with constipation, the auricular plaster and acupoint application can effectively improve the constipation symptoms, shorten the defecation time, improve the cure rate of the disease, and ensure the normal defecation cycle in the patients.

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Effect of Auricular Acupoint Bloodletting plus Auricular Acupressure on Sleep Quality and Neuroendocrine Level in College Students with Primary Insomnia: A Randomized Controlled Trial

Chen

Mingjian

et al. 2022

Chin. J. Integr. Med.

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Treatment of acne vulgaris with auricular acupoint pricking-bloodletting plus auricular point sticking therapy: a randomized controlled study

Cited by 4 publications

References 2 publications

Auriculotherapy Modulates Macrophage Polarization to Reduce Inflammatory Response in a Rat Model of Acne

Auriculotherapy Modulates Macrophage Polarization to Reduce Inflammatory Response in a Rat Model of Acne

Observation on the Curative Effect of Auricular Acupoint Sticking Combined with Acupoint Sticking in the Treatment of Diabetic Constipation

Effect of Auricular Acupoint Bloodletting plus Auricular Acupressure on Sleep Quality and Neuroendocrine Level in College Students with Primary Insomnia: A Randomized Controlled Trial

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