Effect of Auricular Acupoint Bloodletting plus Auricular Acupressure on Sleep Quality and Neuroendocrine Level in College Students with Primary Insomnia: A Randomized Controlled Trial

Chen, Hao; Mingjian, Zhang; Wu, Jia-Ai; She, Yan-Fen; Yuan, Xinru; Huo, Yun-Xiang; Sun, Hongjian; Liu, Dao-Nan; Shi, Xuliang

doi:10.1007/s11655-022-3581-0

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…Studies have shown that there is an imbalance of glutamate (Glu)/γaminobutyric acid in insomnia patients, and acupuncture may improve insomnia symptoms by regulating glutamate (Glu)/γaminobutyric acid-Gln metabolism. [24,25] Table 3 Comparison of neurotransmitter levels between 2 groups. The results further showed that 3 months after treatment, the adverse reactions in 2 groups were inconspicuous, and study group has a lower recurrence rate, revealing that Ningshen mixture combined with acupuncture in treating climacteric insomnia has higher safety and can reduce the recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

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Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

Cai,

Zhang,

et al. 2024

Medicine

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Background: In recent years, the incidence of menopause insomnia has gradually increased, seriously affecting women's physical and mental health. Methods: Total 82 climacteric insomnia patients received from January 2021 to January 2023 were divided into 2 groups at random. In control group, 41 cases received conventional Western medicine, and in study group, 41 cases received acupuncture combined with Ningshen mixture. Clinical effectiveness of both groups was compared, neurotransmitter levels, TCM syndrome integral and Pittsburgh Sleep Quality Index (PSQI) were assessed in both groups. Meanwhile, the recurrence rate and safety were evaluated in 2 groups. Results: The curative effect in study group was better than that in control group (P < .05). After treatment, the expressions of 5-hydroxytryptamine and β-endorphin (β-EP) in study group were higher than control group (P < .05); TCM syndrome scores and PSQI scores in study group were lower than control group (P < .05). The total recurrence rate in study group was obviously lower than control group at 3 months after treatment (P < .05). There were no serious adverse reactions in both group, and no distinct difference between 2 groups was found (P > .05). Conclusion: Acupuncture united with Ningshen mixture has a significant therapeutic effect and high safety in climacteric insomnia patients. It can effectively improve the neurotransmitter levels, clinical symptoms and sleep quality, and reduce the recurrence rate of climacteric insomnia patients, which has high clinical application value and is worthy of clinical promotion.

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Section: Discussionmentioning

confidence: 99%

“…Studies have shown that there is an imbalance of glutamate (Glu)/γ-aminobutyric acid in insomnia patients, and acupuncture may improve insomnia symptoms by regulating glutamate (Glu)/γ-aminobutyric acid-Gln metabolism. [24,25]…”

Section: Discussionmentioning

confidence: 99%

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

Cai,

Zhang,

et al. 2024

Medicine

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“…Our previous study found that using auricular acupoint therapy, auricular acupoint bloodletting plus auricular acupressure (AB + AA), can improve insomnia symptom of college students. 12 AB + AA had a stronger cumulative effect and long-term e cacy and the clinical effective rate of reached 86.1% after 4 weeks treatment. In the follow-up, it was better than AA in improving the curative effect score of CM syndromes.…”

Section: Introductionmentioning

confidence: 90%

“…The procedure of auricular acupoint therapy is performed according to the previously published literature. 12 The procedure of placebo auricular acupressure is as follows: When the patient is seated, the operator wipes the patient's ear with a 75% ethanol cotton ball, and applies the disposable auricular acupoint paster (replacing the seeds with a sponge ball of the same size) to the auricular acupoints. After xation, the patient is instructed not to press until the next treatment.…”

Section: Interventionsmentioning

confidence: 99%

The effectiveness and satefy of auricular acupoint therapy for patients with chronic insomnia: study protocol for a randomized controlled trial

Chen

Xi-fen

Zhang

et al. 2023

Preprint

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Background: Chronic insomnia (CI) is the most common subtype of insomnia. Auricular acupoint therapy (auricular acupoint bloodletting plus auricular acupressure) is a common treatment for CI, but its efficacy is uncertain due to the poor quality of previous studies. The purpose of this study is to evaluate the efficacy and safety of auricular acupoints in the treatment of CI by comparing with sham auricular acupoint therapy. Methods: This is a multicenter, randomized, two-arm interventional clinical trial. Participants will participate in the study for a total of 18 weeks, consisting of three phases: 2 weeks of screening, 4 weeks of treatment, and 12 weeks of follow-up. Based on the response rate of the primary outcome in our previous study, 156 randomly allocated participants are planned. Eligible participants will be randomly assigned to the auricular acupoint therapy group and sham auricular acupoint therapy group according to a ratio of 1:1. A total of 8 sessions in 4-week treatment period will be carried out. The primary outcome is a response rate at week 4, and the responder is defined as the percentage of those having at least 3 points reduction in insomnia symptoms from baseline as measured via the Pittsburgh Sleep Quality Index (PSQI). Furthermore, response rates at other weeks, PSQI, Insomnia Severity Index (ISI), Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), World Health Organization Quality of Life Scale-Abbreviated Form (WHOQOL-BREF), as well as sleep efficiency (SE), sleep arousal frequency (SA) and total sleep time (TST) recorded by actigraphy are chosen as secondary outcomes. Trial registration: www.chictr.org.cnIdentifer: ChiCTR2200065187, Registered 31 Oct 2022.

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“…Auricular acupressure effectively improved the sleep-wake cycle in rats with acute insomnia. Clinical studies have shown that auricular bleeding (AB) and auricular acupoint pressing (AA) can promote the secretion of melatonin (MT) and increase the levels of glutamate (Glu) and γ-aminobutylene acid (GABA) which are beneficial in the treatment of insomnia [111] . This study provides a theoretical basis for acupuncture to improve long-term insomnia in patients with COVID-19.…”

Section: Acupoint Stimulation May Relieve Other Symptoms Of Long Covidmentioning

confidence: 99%

Acupoint stimulation for long COVID: A promising intervention

Feng

Rong

2023

World Journal of Acupuncture - Moxibustion

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Effect of Auricular Acupoint Bloodletting plus Auricular Acupressure on Sleep Quality and Neuroendocrine Level in College Students with Primary Insomnia: A Randomized Controlled Trial

Cited by 7 publications

References 15 publications

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial

The effectiveness and satefy of auricular acupoint therapy for patients with chronic insomnia: study protocol for a randomized controlled trial

Acupoint stimulation for long COVID: A promising intervention

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