Treatment of acanthosis nigricans with oral isotretinoin

Katz, R. A.

doi:10.1001/archderm.116.1.110

Cited by 22 publications

(13 citation statements)

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“…Nevertheless, AN was not cured, and relapses of AN could be found after stopping the treatment and further treatments were required to maintain the overall improved status. [ 10 11 ] The extended duration of treatments and the safety of topical 0.1% adapalene use in children should be studied further.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study

et al. 2015

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Aims:To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel.Subjects and Methods:A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation (IGE) scale and the parent's global evaluation (PGE) scale were used to assess the efficacy of the patients’ treatment at the end of the 4th week.Results:The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen.Conclusions:The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

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Section: Discussionmentioning

confidence: 99%

The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study

et al. 2015

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“…Various modalities reported to be successful include retinoids (topical and systemic), calcipotriol, fish oil, and long pulsed (5 msec) alexandrite laser treatment. [ 7 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease

Das

Bhattacharya

Kumar

et al. 2014

Indian Dermatol Online J

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“…anti-pruritic therapy) of the skin lesions can be needed while the patient waits for treatment of the underlying tumor [1]. It has been described that benign AN recurs after the treatment of an underlying endocrine disorder is stopped [14][15][16]. To our knowledge, no cases of recurrent AN due to a recurrence of the primary tumor have been described.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Acanthosis Nigricans, Leser-Trélat and Tripe Palms Associated With Gastro-Esophageal Junction Adenocarcinoma: A Case Report

Hagen

2011

J Med Cases

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Acanthosis nigricans is a skin condition that is characterized by velvety, hyperpigmented and occasionally pruritic plaques, mostly seen in the fl exural areas. It can occur as a paraneoplastic phenomenon, most frequently in association with an adenocarcinoma of gastrointestinal origin. The sign of Leser-Trélat is defi ned as an eruption of numerous seborrheic keratoses, and can be associated with acanthosis nigricans. Also, acanthosis nigricans can be associated with tripe palms, a velvety, warty thickening of the palms' surface with exaggerated dermatoglyphics, and with papillomatosis of the oral mucosa. A 62-year old woman presented with a rapid onset of hyperpigmented plaques, multiple (seborrheic) warts, tripe palms and papillomatous hyperplasia of her oral mucosa. A skin biopsy confi rmed acanthosis nigricans. Because of her age and the quite sudden development of the skin lesions, the paraneoplastic variant of this condition was suspected and the patient was referred to a medical oncologist. As part of extensive diagnostic screening, an upper gastro-intestinal endoscopy was performed revealing an esophageal tumor at 30 to 35 cm from the incisors. She underwent an esophagectomy after neoadjuvant chemoradiotherapy. The tumor was staged as ypT2N1M0 adenocarcinoma, which had been radically resected (R0). The tumor showed extensive histomorphological regression. During the neoadjuvant therapy the skin lesions and the mucosal swelling with which the patient initially presented regressed, and disappeared almost completely six months after surgery. The presented case shows the combination of acanthosis nigricans, the sign of Leser-Trélat, tripe palms and extensive oral papillomatosis, which led to the detection of an adenocarcinoma of the gastro-esophageal junction, a tumor that has been reported in association with malignant acanthosis nigricans.

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Treatment of acanthosis nigricans with oral isotretinoin

Cited by 22 publications

References 0 publications

The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study

The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: A pilot study

Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease

Paraneoplastic Acanthosis Nigricans, Leser-Trélat and Tripe Palms Associated With Gastro-Esophageal Junction Adenocarcinoma: A Case Report

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