Treatment of a central giant cell granuloma with intralesional corticosteroid

Abdo, Evandro Neves; Alves, Luciana Mendonça; Rodrigues, Alessandra Sabrina; Mesquita, Ricardo Alves; Gomez, Ricardo Santiago

doi:10.1016/j.bjoms.2004.08.015

Cited by 69 publications

(49 citation statements)

References 9 publications

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“…Although these criteria present some subjective topics, such as 'increased difficulty of the injection', the treatment is usually performed by the same surgeon so increasing the difficulty of the injection can be measured. This finding is reported by several authors, [18][19][20]24 and it reflects the ossification of the lesion. It is recommended that the surgeon takes notes about the resistance of the injections.…”

Section: Methodssupporting

confidence: 84%

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Nogueira

Faria

Osterne

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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Section: Methodssupporting

confidence: 84%

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Nogueira

Faria

Osterne

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…The conventional treatment is curettage and conservative surgical approach, but nonsurgical treatment by intralesional instillation of corticosteroids or calcitonin injections have also been reported [1,17] with variable success rates.…”

Section: Discussionmentioning

confidence: 99%

Quantitative expression analysis of apoptotic/antiapoptotic genes and association with immunolocalization of BAX and BCL-2 in peripheral and central giant cell lesions of the jaws

et al. 2011

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Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) of the jaws are characterized by multinucleated osteoclast-like giant cells in a background of mononuclear cells. While mononuclear cells retain proliferative activity in both lesions, giant cells are Ki-67 negative. This observation raised the theory that giant cells are formed by cytoplasmic fusion of mononuclear cells, and also that these lesions are of reactive nature. As the giant cells are not proliferating in CGCL and PGCL, apoptosis of such cells should be investigated. We investigated the transcription of BAX and BCL-2 mRNAs in six fresh samples of CGCL and six fresh samples of PGCL by qRT-PCR (quantitative reverse transcription PCR) and used immunohistochemistry to demonstrate the localization of these proteins, as well as caspase 3 active in six paraffin-embedded samples of CGCL and nine paraffin-embedded samples of PGCL. While both groups showed increased expression of BAX and BCL-2 mRNA, PGCL showed a higher apoptotic index (ratio BAX/BCL-2) than CGCL. The three proteins investigated were expressed almost exclusively in the cytoplasm of giant cells. To further confirm apoptotic activity, we performed TUNEL analysis in the same samples of the immunohistochemistry and found a higher positivity in the giant cells of PGCL compared to the giant cells of CGCL. Our results show increased expression of apoptotic-related genes in both PGCL and CGCL and that the giant cells are probably the main source of these events. Also, it raises a hypothesis that differences in the apoptotic activity might be associated with the different clinical behavior of CGCL and PGCL.

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“…Glucocorticoids impair this complex formation and induce apoptosis of the immature thymocytes (17). Corticosteroids have been used successfully in the treatment of certain cases of giant cell lesions of the jaws (18)(19)(20). A previous study showed that glucocorticoids inhibit osteoclast precursor proliferation (21).…”

Section: Discussionmentioning

confidence: 99%

Increased expression of NFATc1 in giant cell lesions of the jaws, cherubism and brown tumor of hyperparathyroidism

et al. 2011

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Abstract.A variety of diseases of the jaws may present multinucleated giant cells. These diseases include central giant cell lesions (CGCL), peripheral giant cell lesions (PGCL), brown tumor of hyperparathyroidism (BTH), and cherubism. The multinucleated giant cells in these lesions are osteoclast-like. Since NFATc1 plays a significant role in osteoclast differentiation, the present study aimed to compare the expression of NFATc1 in CGCL, PGCL, BTH and cherubism. A total of 14 formalin-fixed and paraffin-embedded tissue samples of CGCL (n=4), PGCL (n=5), BTH (n=3) and cherubism (n=2) were included in the study. An immunohistochemical analysis was performed to investigate the NFATc1 protein.The majority of giant cells in all of the cases were positive for nuclear NFATc1 and the immunostaining pattern was similar in all of the groups. Although our study supports the hypothesis that giant cell accumulation in PGCL, CGCL, BTH and cherubism is mediated by NFATc1, functional studies are required to investigate this hypothesis.

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Treatment of a central giant cell granuloma with intralesional corticosteroid

Cited by 69 publications

References 9 publications

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

Quantitative expression analysis of apoptotic/antiapoptotic genes and association with immunolocalization of BAX and BCL-2 in peripheral and central giant cell lesions of the jaws

Increased expression of NFATc1 in giant cell lesions of the jaws, cherubism and brown tumor of hyperparathyroidism

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