Treatment of 16 patients with bullous pemphigoid with oral tetracycline and niacinamide and topical clobetasol

Hornschuh, Barbara; Hamm, Henning; Wever, Sabine; Hashimoto, Takashi; Schröder, Ulf; Bröcker, Eva‐B.; Zillikens, Detlef

doi:10.1016/s0190-9622(97)70336-0

Cited by 63 publications

(37 citation statements)

References 13 publications

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“…We conducted a monocenter retrospective study of newly diagnosed BP with clinical, histological and immunological classical criteria [14] between June 2006 and July 2009. All patients were diagnosed after the inclusion periods of the PB1 and PB2 studies.…”

Section: Methodsmentioning

confidence: 99%

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Management of Bullous Pemphigoid with Topical Steroids in the Clinical Practice of a Single Center: Outcome at 6 and 12 Months

Ingen‐Housz‐Oro

Valeyrie‐Allanore

Ortonne³

et al. 2011

Dermatology

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Background: The efficacy of topical steroids in bullous pemphigoid (BP) was assessed by prospective therapeutic trials. Systemic corticosteroids and immunosuppressant agents are indicated in situations of failure or relapses. Objectives: To report our experience in the management of BP outside therapeutic trials focusing on the outcome of the patients at 6 and 12 months, compliance and follow-up difficulties. Methods: Monocenter retrospective study with collection of clinical, therapeutic and follow-up data after 6 and 12 months. Results: Ninety-six patients, mean age 84 years, 65 females, 54% had neurological impairment. The initial dose of clobetasol propionate was 30 g/day, followed by a progressive decrease. In the first 6 months, 14% were lost to follow-up and 17.7% died; 62% were controlled with topical steroids alone, and 25% had adjunctive systemic treatment. Difficulties of compliance were mentioned in 34.4%, without significant difference between controlled and noncontrolled patients. After 12 months, 23% were lost to follow-up and 27.1% died. The mean duration of the treatment was 11.7 ± 8.4 months. After the stop, 18.9% of patients relapsed within 3 months. Conclusion: We emphasize the frequent recourse to systemic treatments in the first few months, the difficulties of compliance and of follow-up in our day-to-day experience.

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Section: Methodsmentioning

confidence: 99%

“…Oral corticosteroids are still used when the application of topical steroid is too difficult. Immunosuppressant agents such as methotrexate or mycophenolate mofetil are prescribed in cases of resistance or dependence to steroids [11,12,13,14]. …”

Section: Introductionmentioning

confidence: 99%

Management of Bullous Pemphigoid with Topical Steroids in the Clinical Practice of a Single Center: Outcome at 6 and 12 Months

Ingen‐Housz‐Oro

Valeyrie‐Allanore

Ortonne³

et al. 2011

Dermatology

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“…The doxycycline-niacinamide regimen followed a modification of a previously reported protocol. 18 Doxycyline, 100 mg orally, was given 2 times daily in combination with niacinamide, 400 mg orally, 3 times daily, and topical 0.5% clobetasol propionate. After cessation of new blister formation and healing of pre-existing lesions, topical treatment was changed to a moisturizing emollient.…”

Section: Patientsmentioning

confidence: 99%

Serum Levels of Autoantibodies to BP180 Correlate With Disease Activity in Patients With Bullous Pemphigoid

Schmidt¹,

Obe²,

Bröcker³

et al. 2000

Arch Dermatol

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315

257

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“…18,19,[23][24][25][26] In PV and BP, most authors 16,18,19,[23][24][25][26] report efficacy at least equal to that of previous immunosuppressive therapies, and some suggest use of tetracyclines as a first-line agent in light of their favorable side effect profile. Although most studies focus on the efficacy and adverse effects of tetracycline therapy, minocycline has been used often as an initial agent 16 or as an alternative if tetracycline adverse effects develop.…”

Section: Commentmentioning

confidence: 99%

Minocycline-Induced Hyperpigmentation in Patients With Pemphigus and Pemphigoid

Ozog

Gogstetter²,

Scott³

et al. 2000

Arch Dermatol

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Treatment of 16 patients with bullous pemphigoid with oral tetracycline and niacinamide and topical clobetasol

Cited by 63 publications

References 13 publications

Management of Bullous Pemphigoid with Topical Steroids in the Clinical Practice of a Single Center: Outcome at 6 and 12 Months

Management of Bullous Pemphigoid with Topical Steroids in the Clinical Practice of a Single Center: Outcome at 6 and 12 Months

Serum Levels of Autoantibodies to BP180 Correlate With Disease Activity in Patients With Bullous Pemphigoid

Minocycline-Induced Hyperpigmentation in Patients With Pemphigus and Pemphigoid

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