Minocycline-Induced Hyperpigmentation in Patients With Pemphigus and Pemphigoid

Ozog, David M.; Gogstetter, Darin S.; Scott, Glynis; Gaspari, Anthony A.

doi:10.1001/archderm.136.9.1133

Cited by 51 publications

(32 citation statements)

References 34 publications

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“…Inhibits mitochondrial permeability transition pore by reducing mitochondrial Ca 2ϩ uptake, decreases release of mitochondrial pro-apoptotic, increases anti-apoptotic factors, and also modulates the activity of poly(ADPribose) polymerase (41) Used a steroid-sparing drug to treat PV patients alone or in combination with nicotinamide (34,(57)(58)(59)(60) …”

Section: Minocyclinementioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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Background: Previous studies suggested that mitochondrial antibodies contribute to pemphigus vulgaris (PV). Results: PV sera elicited mitochondrial damage, and mitochondria-protecting drugs exhibited protective effect in cell culture and mouse skin. Conclusion: PV antibodies altered O 2 respiration, disrupted electron transfer chain, and increased reactive oxygen species. Significance: Results provide the mechanism of therapeutic action and justify the use of mitochondria-protecting drugs in PV.

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Section: Minocyclinementioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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“…Minocyclin zeigt die beste Absorption, Lipophilie und Gewebspenetration und wird im Gegensatz zu Tetracyclin und Doxycyclin vor der renalen Exkretion in der Leber abgebaut. Die Inzidenz der Minocyclin-induzierten Hyperpigmentierung scheint beim bullösen Pemphigoid und bei Pemphiguserkrankungen höher zu sein als bei Acne vulgaris oder rheumatoider Arthritis; allerdings zeigt der Prozess meist eine gewisse Reversibilität [20]. Schwerwiegendere Nebenwirkungen können in der Induktion von Autoimmunphänomenen bestehen.…”

Section: Tetracyclineunclassified

Orale Antibiotika mit antiinflammatorischer/immunmodulatorischer Wirkung für die Therapie verschiedener Dermatosen

Brinkmeier

Frosch

2002

Hautarzt

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A range of antibiotics has been shown to modify host functions apart from the antimicrobial potency. They may directly influence phagocyte and lymphocyte function, as well as chemotaxis. Effects on the generation and release of various cytokines involved in the inflammatory process have been studied both in vivo and in vitro. However, the molecular mechanisms have not been elucidated in detail. It is suggested that antibiotics can exert immunopharmacological effects on the basis of structure-activity relationships independent of their antibacterial activity. We present a collection of clinical studies and case reports dealing with the potential benefits of systemic antibiotics in the treatment of selected dermatoses which have primarily been classified as non-infectious. Generally accepted treatments such as dapsone in dermatitis herpetiformis and leukocytoclastic vasculitis or chloroquine in lupus erythematosus have not been considered. Based on existing clinical trials with a higher number of cases the following antibiotics have been shown to be effective: erythromycin in bullous pemphigoid and pityriasis rosea as well as tetracyclines in pemphigus vulgaris, bullous pemphigoid and pustulosis palmaris et plantaris. However, most reports have to be viewed critically due to the uncontrolled study design, particularly in dermatoses with a tendency to spontaneous resolution. Despite this lack of evidence-based data, it is important for the clinician to know about the potential use of antibiotics for various skin disorders as a primary treatment option or steroid-sparing therapeutic adjunct. In clinical practice the use of antibiotics depends on various factors including the severity of the disease, the patient's age, contraindications to conventional therapeutic regiments and economic considerations.

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“…Das Problem der Chronizität und des Rezidivrisikos dieser Erkrankung stellt zudem Anforderungen an eine nebenwirkungsarme und gut tolerierbare Akut-und Langzeittherapie. Es soll in diesem Zusammenhang nicht unerwähnt bleiben, dass neben dem Minocyclin-induzierten Lupus erythematodes [19] -wie in unserem Fall -Hyperpigmentierungen als Nebenwirkungen einer Minocyclintherapie auftreten können [16]. Auch bei erfolgreichen Therapien müssen Nutzen und Risiko laufend sorgfältig abgewogen werden.…”

Section: Diskussionunclassified