Treatment models of cardiac rehabilitation in patients with coronary heart disease and related factors affecting patient compliance

doi:10.31083/j.rcm.2019.01.53

Cited by 43 publications

(28 citation statements)

References 42 publications

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“…Our study demonstrated higher level of non-adherence with secondary prevention medications in patients with CHD (60.0%) than was broadly consistent in the modern literature data [7,8,11,12]. This fact can be explained by the socioeconomic reasons, less informative strategies from the medical staff to the patients, especially general practitioners.…”

Section: Discussionsupporting

confidence: 89%

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Investigation of the Adherence to Prescribed Treatment of the Patients with Coronary Heart Disease

Shuper¹,

Shuper²,

Trefanenko³

et al. 2021

Ukr. ž. med. bìol. sportu

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The purpose of the study was to investigate the adherence to secondary prevention medications among patients with coronary heart disease and identify factors associated with it. Materials and methods. We examined 40 patients diagnosed with coronary heart disease of more than 50 years old, who were prescribed with optimal medication for 1 year during hospitalization. Patients` adherence was defined according to MMS-8 Morisky values for secondary prevention medications prescribed by doctors. Also, questionnaires about individual reasons of non-compliance and for individual patient`s opinion about importance and usefulness of knowledge according to risk factors of the increase of cardiovascular mortality were designed and proposed to the patients. Simple descriptive statistics were used to elucidate the characteristics of the patient population and results from individual adherence tools. Final score was analyzed and correlation between patients’ data and level of adherence to prescribed treatment were identified. A correlation matrix (using Spearman’s coefficient) was reviewed for any evidence of collinearity. Results and discussion. Our study demonstrated higher level of non-adherence with secondary prevention medications in patients with coronary heart disease (60.0%). This fact can be explained by the socioeconomic reasons, less informative strategies from the medical staff to the patients. Severe regress of adherence was demonstrated after discharge from the hospital due to subjective improvement of the patients` condition with absence of supervision by out-patient specialists. Demographic characteristics of the patients suggested that some non-modified factors can affect compliance with the prescribed treatment. Better adherence was demonstrated by female married patients with higher educational level, with family history about cardiovascular death. Also, too much prescribed medications with difficult regime of usage with non-adequate out-patient supervision may significantly decrease adherence causing development of complications which may lead to re-hospitalizations and cardiovascular death. Our investigation demonstrated also non-complete information of the patients about lifestyle and medical risk factors of the cardiovascular mortality increase. Conclusion. The results of our study can provide useful practical information on the prevalence and severity of non-adherence among patients with coronary heart disease. Analysis of the factors influencing the adherence demonstrated the main reasons from patients and healthcare professionals affecting the level of compliance with the prescribed treatment. The step towards improving adherence can be initiated by the healthcare professional to overcome the patient's concerns about the prescribed medication. It is important to continue personal monitoring of patients by healthcare professionals in the form of regular inspections of intentional and unintentional non-adherence, including factors and reasons that may change and lead to such behavior

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Section: Discussionsupporting

confidence: 89%

“…Healthcare professionals should assess, elicit and explore patients' beliefs and experiences with their medications to help them make informed choices and decrease non-adherence. This requires the use of specific tools that can be deployed in clinical practice to explore and address barriers to proper medications usage [8,9].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Adherence to Prescribed Treatment of the Patients with Coronary Heart Disease

Shuper¹,

Shuper²,

Trefanenko³

et al. 2021

Ukr. ž. med. bìol. sportu

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“…Coronary heart disease is a disease caused by coronary artery stenosis or occlusion of myocardial ischemia, hypoxia, or necrosis. As the course of the disease increases, it can increase the incidence of chronic heart failure [ 1 ]. At present, the clinical treatment of coronary heart disease mainly focuses on reducing blood lipids, preventing risk factors, and symptomatic treatment.…”

Section: Introductionmentioning

confidence: 99%

Intervention Effect of Probiotics in Gastric Cancer Patients with Complications of Coronary Heart Disease and Heart Failure

Dong

Zhao

et al. 2021

Journal of Oncology

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Objective. To investigate the characteristics of intestinal flora in patients with gastric cancer complicated by coronary heart disease and heart failure and the guiding value of probiotics intervention for clinical treatment. Methods. (1) One hundred and sixty-eight gastric cancer patients with complications of coronary heart disease and heart failure from August 2017 to December 2020 were selected as the observation group. A total of 125 patients with coronary heart disease treated at the same time were selected as control group 1, and 89 healthy subjects were selected as control group 2. Fecal samples were retained to extract the total RNA, and high-throughput sequencing was applied to complete the analysis of microbial diversity and structure differences, so as to obtain the biological species information of the specimens. (2) Patients in the observation group were randomly divided into two equal groups of 84 patients, namely, group A and group B. Group A was treated with conventional methods, and group B was combined with probiotics intervention on the basis of group A; then, the differences in the intestinal mucosal barrier between the two groups were compared. Results. The Chao, ACE, and Simpson index in the observation group were lower than those in control group 1 ( P < 0.05 ), and the Shannon index was higher than that in control group 1 ( P < 0.05 ). The Chao, ACE, and Shannon index in control group 1 were lower than those in control group 2 ( P < 0.05 ), whereas the Simpson index was higher than in control group 2 ( P < 0.05 ). The abundance of Bacteroidetes in the observation group was lower than that in control group 1 and control group 2 ( P < 0.05 ). The abundance of Firmicutes was higher than that of control group 1 and control group 2 ( P < 0.05 ). Four weeks after treatment, the levels of ET, D-lactic acid, and PCT in the group B were (0.10 ± 0.01), (3.99 ± 0.32), and (0.41 ± 0.10), respectively, which were lower than those in group A (0.19 ± 0.03), (4.51 ± 0.46), and (0.81 0.13). Conclusion. Gastric cancer patients with complications of coronary heart disease and heart failure are associated with intestinal flora disorder, which may be involved in the occurrence and development of the disease. Probiotics intervention is helpful to repair the intestinal mucosal barrier in patients, which is worthy of popularization and application.

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“…The incidence of cardiovascular diseases has been on the rise annually with the onset of aging. In particular, coronary heart disease is becoming increasingly common (1,2). Although percutaneous coronary intervention (PCI) is a commonly used method to treat atherosclerotic coronary heart disease, postoperative restenosis occurs in a considerable proportion of angioplasty patients, leading to a reduction in the success rate of PCI treatment whilst increasing the risk of new cardiovascular complications (3).…”

Section: Introductionmentioning

confidence: 99%

COL6A1 knockdown suppresses cell proliferation and migration in human aortic vascular smooth muscle cells

Chen

Yan

et al. 2019

Exp Ther Med

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Vascular smooth muscle cell (VSMC) migration is an important pathophysiological signature of neointimal hyperplasia. The aim of the present study was to investigate the effects of collagen type VI α1 chain (COL6A1) on VSMC migration. COL6A1 expression was silenced in platelet-derived growth factor (PDGF-BB)-stimulated VSMCs. Cell counting kit-8, wound healing and Transwell assays were used to measure cell viability, migration and invasion, respectively. Reverse transcription-quantitative PCR and western blot analysis were performed to analyze the expression of factors associated with metastasis. COL6A1 silencing attenuated PDGF-BB-induced increases in cell viability and invasive abilities of VSMCs, in addition to partially reversing the increased expression of fibronectin (FN), matrix metalloproteinase (MMP)-2 and MMP-9 induced by PDGF-BB stimulation. The silencing of COL6A also overturned PDGF-BB-induced reduction in tissue inhibitor of metalloproteinase 2 expression in VSMCs. PDGF-BB activated the AKT/mTOR pathway, which was also inhibited by COL6A1 knockdown. Taken together, these findings suggest that COL6A1 silencing inhibited VSMC viability and migration by inhibiting AKT/mTOR activation.

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Treatment models of cardiac rehabilitation in patients with coronary heart disease and related factors affecting patient compliance

Cited by 43 publications

References 42 publications

Investigation of the Adherence to Prescribed Treatment of the Patients with Coronary Heart Disease

Investigation of the Adherence to Prescribed Treatment of the Patients with Coronary Heart Disease

Intervention Effect of Probiotics in Gastric Cancer Patients with Complications of Coronary Heart Disease and Heart Failure

COL6A1 knockdown suppresses cell proliferation and migration in human aortic vascular smooth muscle cells

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