Treatment modalities of bladder/prostate rhabdomyosarcoma: a review

Ashlock, Robert B.; Johnstone, Peter A.S.

doi:10.1038/sj.pcan.4500652

Cited by 16 publications

(7 citation statements)

References 69 publications

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“…This is also attributed in part to early diagnosis and timely referral to specialised centres [24]. Also, a focus on bladder preservation has not adversely affected survival in most studies [3] and in cases where organ preservation is not possible, improvements in urinary diversion techniques still offer improved quality of life [1]. Although limited reports exist in the literature about the less invasive local excision, there is mounting evidence that combination of local excision with adjuvant chemotherapy give excellent outcomes with 2-year survival rates of >96% [4,6,28].…”

Section: Discussionmentioning

confidence: 97%

Management of stage I cervical sarcoma botryoides in childhood and adolescence

et al. 2004

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Section: Discussionmentioning

confidence: 97%

Management of stage I cervical sarcoma botryoides in childhood and adolescence

et al. 2004

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“… 4 Ashlock et al reported improved survival and quality of life outcomes in children treated with multimodality therapy. 5 However, in adults the prognosis remains poor. The 70 Gy dose delivered to our patient allowed local control of the disease without toxicity.…”

Section: Discussionmentioning

confidence: 99%

Prostate rhabdomyosarcoma in a young adult: Case report and literature review

Sow

Sarr

Niang

et al. 2021

Urology Case Reports

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Primary rhabdomyosarcoma of the adult prostate is rare and associated with an aggressive clinical course. Combined modality therapy has resulted in marked improvement in survival rates and reduced surgical morbidity for children with these tumors. However, in adults the prognosis remains poor.We report on a case of prostate rhabdomyosarcoma in an adult approached with combined-modality treatment, with the administration of 9 courses of doxorubicin, vincristine and endoxan, and, subsequent radiotherapy to the prostaticbed. The patient remained free of progression of disease for about 1 year.

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“…Data on bladder RMS can only be extracted from studies on large series of RMS arising in different sites. Most of the available literature on bladder RMS shows its association with embryonal variants [ 16 - 18 ]. Within 65 specimens of bladder and vagina RMS, Leuschner et al found 51 urinary bladder RMS and 14 vaginal RMS.…”

Section: Rhabdomyosarcomamentioning

confidence: 99%

“…Despite improvements in morphological and cytological examination, as many as one third of the patients could be incorrectly assigned to treatment protocols because of inconsistency and uncertainty as determined by institutional pathology diagnosis [ 18 ]. Genomic analysis of human tumor specimens has an increasingly significant impact on the field of tumor pathology [ 23 , 24 ], redefining tumor classes based on molecular features [ 25 , 26 ] and identifying new subclasses previously unrecognized by conventional histology or cytogenetics.…”

Section: Rhabdomyosarcomamentioning

confidence: 99%

Genetics of Bladder Malignant Tumors in Childhood

Zangari¹,

Zaini²,

Gulìa³

2015

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Bladder masses are represented by either benign or malignant entities. Malignant bladder tumors are frequent causes of disease and death in western countries. However, in children they are less common. Additionally, different features are found in childhood, in which non epithelial tumors are more common than epithelial ones. Rhabdomyosarcoma is the most common pediatric bladder tumor, but many other types of lesions may be found, such as malignant rhabdoid tumor (MRT), inflammatory myofibroblastic tumor and neuroblastoma. Other rarer tumors described in literature include urothelial carcinoma and other epithelial neoplasms. Rhabdomyosarcoma is associated to a variety of genetic syndromes and many genes are involved in tumor development. PAX3-FKHR and PAX7-FKHR (P-F) fusion state has important implications in the pathogenesis and biology of RMS, and different genes alterations are involved in the pathogenesis of P-F negative and embryonal RMS, which are the subsets of tumors most frequently affecting the bladder. These genes include p53, MEF2, MYOG, Ptch1, Gli1, Gli3, Myf5, MyoD1, NF1, NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB1, FBXW7, IGF1R, PDGFRA, ERBB2/4, MET, BCOR. Malignant rhabdoid tumor (MRT) usually shows SMARCB1/INI1 alterations. Anaplastic lymphoma kinase (ALK) gene translocations are the most frequently associated alterations in inflammatory myofibroblastic tumor (IMT). Few genes alterations in urothelial neoplasms have been reported in the paediatric population, which are mainly related to deletion of p16/lnk4, overexpression of CK20 and overexpression of p53. Here, we reviewed available literature to identify genes associated to bladder malignancies in children and discussed their possible relationships with these tumors.

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Treatment modalities of bladder/prostate rhabdomyosarcoma: a review

Cited by 16 publications

References 69 publications

Management of stage I cervical sarcoma botryoides in childhood and adolescence

Management of stage I cervical sarcoma botryoides in childhood and adolescence

Prostate rhabdomyosarcoma in a young adult: Case report and literature review

Genetics of Bladder Malignant Tumors in Childhood

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