Prostate rhabdomyosarcoma in a young adult: Case report and literature review

Sow, Ousmane; Sarr, Alioune; Niang, Dibor; Mbow, Aboubacry; Sow, Yaya; Ndoye, Alain Khassim

doi:10.1016/j.eucr.2021.101745

Cited by 4 publications

(7 citation statements)

References 5 publications

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“…In addition, the overall cure rates have improved significantly thanks to the multimodal therapies, including surgery, radiation therapy, and chemotherapeutics (with various combinations of vincristine, actinomycin D, cyclophosphamide, etoposide, irinotecan, or ifosfamide). We closely studied recent cases of different locations (paratesticular, prostate, biliary and uterine) of RMS and found surgical therapy is the key basis and significant treatment for a better prognosis of patients with RMS except with orbital rhabdomyosarcoma (19)(20)(21)(22)(23)(24). These available findings are consistent with our review.…”

Section: Discussionsupporting

confidence: 85%

Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime

Yang

et al. 2022

Front. Med.

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Primary intrahepatic rhabdomyosarcoma is an extremely rare malignant tumor. Here, we describe a case of embryonal rhabdomyosarcoma of the liver in a 7-year-old boy without any symptoms. Serologically, the patient showed abnormal levels of serum tumor markers and liver function. Imaging revealed a large mass in the left lobe of the liver and no lesions elsewhere. At first, the patient was misdiagnosed by percutaneous liver biopsy as having clear cell sarcoma. However, the final diagnosis was established to be hepatic embryonal rhabdomyosarcoma based on postoperative histopathology and typical immunohistochemical staining, which was positive for desmin and myogenin. For treatment, the patient received two cycles of preoperative chemotherapy, prophylactic radiotherapy, and 13 cycles of combined postoperative chemotherapy. Routine follow-ups after all treatment conducted by imaging examinations showed no sign of recurrence or metastasis over 13 months, and the patient survives more than 38 months since initial diagnosis. To our knowledge, this patient is the first with hepatic rhabdomyosarcoma to receive neoadjuvant chemotherapy (preoperative chemotherapy) combined with relative comprehensive treatment and achieve a favorable result.

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Section: Discussionsupporting

confidence: 85%

Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime

Yang

et al. 2022

Front. Med.

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“…In some cases, the combination of radiotherapy and chemotherapy resulted in progression-free survival of about 1 year (up to 49 months). 15 , 30 , 31 However, in a report by Johnson et al., 32 the patient barely responded to three cycles of VAC chemotherapy, radical surgery, and three palliative radiotherapy sessions and died 6 months after diagnosis. Our patient received one course of chemotherapy with the IE regimen followed by two courses of chemotherapy with other regimens, but he responded poorly to treatment regardless of the chemotherapy regimen.…”

Section: Discussionmentioning

confidence: 99%

Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient: a case report and review of the literature

Luo,

Weng,

Zhong

et al. 2024

J Int Med Res

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Rhabdomyosarcoma of the prostate is a rare mesenchymal tumor that originates from undifferentiated mesenchymal cells. Spindle cell rhabdomyosarcoma is a variant of embryonal rhabdomyosarcoma. The vast majority of these two pathological types occur in children, with only a few adult cases reported to date, and both are associated with poor clinical outcomes. We herein report a case involving a man in his early 40s with spindle cell embryonal rhabdomyosarcoma of the prostate. His chief complaint was difficult urination. The diagnosis was confirmed by puncture biopsy of the prostate, and pelvic lymph node metastasis was already present at the time of diagnosis. The patient underwent three courses of chemotherapy. However, his response to the treatment was very poor, and he died of the disease 4 months after diagnosis.

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“…The disease is mostly sporadic but has been observed in several genetic syndromes, including but not limited to Li-Fraumeni syndrome, neurofibromatosis type I, and Costello syndrome [8]. Prostatic RMS is characterized by rapid progression and is typically found to have extensive periurethral, perivesical, and perirectal invasion [9]. This leads to the most common presenting symptoms of urinary retention: urgency, frequency, incontinence, constipation, hematuria, and abdominal mass [7,8].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Prostatic Alveolar Rhabdomyosarcoma Presenting with Metastatic Spinal Cord Compression in the Thoracic Spine: A Case Report and Review of the Literature

Perry,

Witten,

Marwan

et al. 2024

Cureus

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Rhabdomyosarcoma (RMS) is a pediatric malignancy with a variable prognosis depending on tumor stage and genotype. There has been a significant improvement in survival rates over the past decades. However, aggressive variants can metastasize to locations that are difficult to treat. We report a case of prostatic alveolar rhabdomyosarcoma with metastases to the bone marrow and thoracic spine in a child. The patient was treated with a multimodal approach that included surgical resection of the epidural mass; the administration of vincristine, dactinomycin, and cyclophosphamide; and radiotherapy. Unfortunately, after six months, the patient showed disease progression and was started on secondary-line treatment. This case illustrates the difficulties in managing end-stage metastatic rhabdomyosarcoma and is the first report of prostatic rhabdomyosarcoma presenting with spinal cord compression in a child.

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Prostate rhabdomyosarcoma in a young adult: Case report and literature review

Cited by 4 publications

References 5 publications

Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime

Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime

Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient: a case report and review of the literature

Pediatric Prostatic Alveolar Rhabdomyosarcoma Presenting with Metastatic Spinal Cord Compression in the Thoracic Spine: A Case Report and Review of the Literature

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