Treatment in gynecology

Dydrogesterone and Endometriosis

“…However, the criteria of diagnosis of endometriosis may differ between centres and interpretation or recognition of these criteria may be inconsistent. These forms of treatment are not without associated side-effects, the most common of which are reported to be weight gain, nausea (Chalmers, 1968 ;Kistner, 1965;Richter, 1968;Williams, 1967) and menstrual disorders or breakthrough bleeding (Chalmers, 1968;Richter, 1968;Riva et al, 1958).…”

“…Of 49 patients with endometriosis all but five had no subjective symptoms after nine months treatment. These results are in general agreement with results from published series of endometriosis patients treated with other progestogens (Chalmers, 1968;Kistner, 1958;Richter, 1968;Williams, 1967) and with dydrogesterone (Aydar and Greenblatt, 1964;Backer, 1962;Lundgren, 1964;Ullery et al, 1962). The absence of weight gain, oedema, and other troublesome side-effects was striking in this study.…”

“…reported the results of treatment of endometriosis with synthetic progestogens there have been many reports on the use of progestogens or oestrogen/progestogen combinations with a 'success rate' of treatment above 50 per cent. In patients with infertility as well, conception rates of up to 72 per cent have been reported after completion of the treatment course (Williams, 1967). However, the criteria of diagnosis of endometriosis may differ between centres and interpretation or recognition of these criteria may be inconsistent.…”

Experimental studies on intra-abdominal adhesions

“…However, the fundamental etiology of the fibrinous adhesions following abdominal surgery is still poorly known. Mechanical damage, infection (Williams, 1901), reperitonealization, thermal or chemical injuries and foreign bodies (Saxen & Myllamiemi, 1968) have been discussed as causative factors of adhesions.…”