Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer

Cheng, Chunxia; Zhuo, Shuangmu; Zhang, Bo; Zhao, Xu; Liu, Ying; Liao, Chaoliang; Quan, Jing; Li, Zhenzhen; Bode, Ann M.; Cao, Yang

doi:10.7150/ijbs.33837

Cited by 45 publications

(28 citation statements)

References 84 publications

(78 reference statements)

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“…Furthermore, there are molecules that induce apoptosis in different types of cancer by acting specifically on SCD1 [14]. The inhibition of SCD1 through natural compounds can result in health benefits [16][17][18]. The sterculic oil is an extremely precious natural product, capable of inhibiting SCD1 enzyme in obese ob/ob mice, reducing fat accumulation in the liver and adipose tissue and improving inflammation and insulin resistance, factors that create an environment conducive to the development of cancer [17].…”

Section: Introductionmentioning

confidence: 99%

Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines

et al. 2020

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The polyphenolic compounds present in grape extracts have chemopreventive and anticancer properties. Here, we studied the ability of two grape skin extracts (GSEs), Autumn Royal and Egnatia, to influence the cell motility and membrane fluidity regulated by the enzyme Stearoyl-CoA desaturase-1 (SCD1) which increases with the cancer aggressiveness. Caco2 and SW480 human colon cancer cell lines were treated with increasing concentrations of GSEs to evaluate cell proliferation and motility. SCD1 levels were evaluated in both treated cell lines, by membrane lipidomic analysis conducted by gas chromatography. The expression levels of SCD1 and other factors involved in the reorganization of the cytoskeleton and focal adhesions were assessed by Real-time PCR, Western Blotting, and Immunofluorescence staining. High-performance liquid chromatography (HPLC) analyses were performed to determine the phenolic composition in the GSEs, finding them more expressed in Autumn Royal than in Egnatia. Both treatments reduced the levels of SCD1, phospho-Rac1/Cdc42/Rac1/Cdc42 ratio, Cofilin, Vimentin, and phospho-Paxillin especially in Caco2 compared to SW480, showing a different behavior of the two cell lines to these natural compounds. Our findings show that GSEs block the cell migration and membrane fluidity through a new mechanism of action involving structural cellular components.

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Section: Introductionmentioning

confidence: 99%

Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines

et al. 2020

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“…Similarly, MeJA application in our research not only stimulated the presence of (E)‐β‐farnesene but also increased its content. As natural compounds that widely exist in plants, terpenoids could be divided into monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes, tetraterpenes and polyterpenes, among which monoterpenes and sesquiterpenes are common 44 . Classification revealed that terpenoids were dominant in S japonicus flowers, such as α‐pinene, ocimene, myrcene and germacrene‐d.…”

Section: Discussionmentioning

confidence: 99%

Methyl jasmonate application and flowering stage affect scent emission of Styrax japonicus

Chen

et al. 2021

Flavour & Fragrance J

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Styrax japonicus is a gorgeous species with high medicinal and ornamental values. Floral scent is an important feature of this species. However, the previous study on its floral scent is limited. To demonstrate the effects of methyl jasmonate on floral scent compounds in Styrax japonicus at different flowering stages, static headspace solid‐phase microextraction coupled with gas chromatography‐mass spectrometry was adopted. The results showed that 22 volatile compounds were identified in control at initial flowering, full flowering and end flowering stage. Besides, the relative content of these compounds increased with the development of flowers. Linalool, estragole and germacrene‐d were main volatiles. Compared to the control, 4 new compounds were determined under methyl jasmonate treatment, including β‐elemene, α‐muurolene, β‐caryophyllene and alloaromadendrene. 26 volatile compounds were found under 200 μmol/L methyl jasmonate treatment with much higher contents of α‐pinene and linalool. Meanwhile, 200 μmol/L methyl jasmonate enhanced the relative content of volatile compounds at three flowering stages. This treatment also contributed to the highest content of linalool, followed by control. The linalool content displayed a continuous increasement in both 200 μmol/L methyl jasmonate treatment and control. Our research highlighted that the application of methyl jasmonate, especially with the concentration of 200 μmol/L, had a more positive impact on the type and the relative content of volatile compounds in S japonicus flowers. The results helped to understand the release patterns of volatile compounds in S japonicus flowers and provide important information to regulate the floral scents.

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“…ACC is phosphorylated by two upstream factors: AMPK and PPAR-α (Lee & Kim, 2010;Smith et al, 2016;Cheng et al, 2019). We measured the changes in AMPK and PPAR-α expression to identify which factor is related to ACC inhibition following TGPN administration.…”

Section: Regulation Of Lipid Metabolism-related Proteins By Tgpn Administrationmentioning

confidence: 99%

Oyster hydrolysate ameliorates ethanol diet‐induced alcoholic fatty liver by regulating lipid metabolism in rats

Byun¹,

Shin²,

Choi³

et al. 2021

Int J of Food Sci Tech

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We evaluated the effect of oyster hydrolysate, which was prepared using transglutaminase, protamex and neutrase (TGPN), on alcoholic fatty liver. Sprague-Dawley rats were fed a diet containing 5% (v/v) ethanol or an isocaloric amount of dextrin-maltose for 6 weeks and orally administered TGPN or silymarin for another 4 weeks. TGPN significantly decreased the liver index (liver weight/body weight), serum and hepatic lipid levels and increased the serum adiponectin level. Based on histological analysis, TGPN reduced the number of lipid droplets and lipid accumulation in liver tissue. TGPN enhanced the expression of AMP-activated protein kinase and activated its downstream pathway which controls lipid metabolism. Additionally, TGPN decreased the levels of liver function markers (aspartate aminotransferase and alanine aminotransferase) and tumour necrosis factor alpha. Consequently, TGPN ameliorated alcoholic fatty liver by inhibiting fatty acid and cholesterol synthesis, promoting fatty acid oxidation and decreasing liver cell damage.

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Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer

Cited by 45 publications

References 84 publications

Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines

Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines

Methyl jasmonate application and flowering stage affect scent emission of Styrax japonicus

Oyster hydrolysate ameliorates ethanol diet‐induced alcoholic fatty liver by regulating lipid metabolism in rats

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