Treatment for patients with recurrent abortion with positive antiphospholipid antibodies using a traditional Chinese herbal medicine

Takakuwa, Koichi; Yasuda, Masako; Hataya, Isao; Sekizuka, Naoto; Takao, Masaki; Arakawa, Masato; Higashino, Masahiko; Hasegawa, Isao; Tanaka, Kenichi

doi:10.1515/jpme.1996.24.5.489

Cited by 25 publications

(18 citation statements)

References 9 publications

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“…Carreras et al [3] reported that lupus anticoagulant suppressed the production of prostacyclin in the aortic endothelial cells of mice, and they suggested that this condition may induce the production of thromboxane A2, which is a strong vasoconstrictor and inducer of platelet aggregation, and that this would be followed by the formation of thrombi. We and other authors have reported the effectiveness of immune suppression and anticoagulant therapy for patients with recurrent fetal miscarriage who were positive for lupus anticoagulant or aCL-Ab [2,8,13,23,28].…”

Section: Discussionmentioning

confidence: 92%

Anti-cardiolipin antibody and anti-cardiolipin beta-2-glycoprotein I antibody in patients with recurrent fetal miscarriage

Higashino¹,

Takakuwa²,

Arakawa³

et al. 1998

Jpme

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To elucidate the association between anticardiolipin antibody (aCL-Ab) or anti-cardiolipin beta-2-glycoprotein I-antibody (aCL-beta-2-GP I-Ab) and recurrent fetal miscarriage, the positive rates of aCL-Ab were assessed in 667 patients with recurrent fetal miscarriages and those of aCL-beta-2-GP I-Ab were assessed in 208 patients. The rates were then compared with the control group. The positive rate of aCL-Ab in the patients group (17.4%) was significantly higher than that in the control group (4.0%). The rate of aCL-Ab was especially high in patients who had experienced two or more fetal miscarriages including at least one or more intrauterine fetal deaths during the second or third trimester (41.3%). The positive rate of aCL-beta-2-GP I-Ab in patients with recurrent fetal miscarriage (3/208 cases, 1.4%) was not significantly different from the control group (0/100 cases, 0%). However, the rate of aCL-beta-2-GP I-Ab was significantly higher in patients who had experienced two or more fetal miscarriages including at least one or more intrauterine fetal deaths during the second or third trimester (8.3%) compared with the control group. In conclusion, the implication of aCL-Ab in the genesis of recurrent fetal miscarriage was confirmed. It was suggested that aCL-beta-2-GP I-Ab was associated with the generation of intrauterine fetal death, although it had little association with the genesis of recurrent fetal miscarriage during the first trimester.

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Section: Discussionmentioning

confidence: 92%

Anti-cardiolipin antibody and anti-cardiolipin beta-2-glycoprotein I antibody in patients with recurrent fetal miscarriage

Higashino¹,

Takakuwa²,

Arakawa³

et al. 1998

Jpme

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“…None of the participants showed the presence of any genetic impairment, uterine anomalies, endocrine or metabolic disorders. The mean age of the patients was 31 ± 3.8 (25-36) years the number of fetal wastage was 3.6 ± 1.85 (2)(3)(4)(5)(6)(7)(8), and the number of living children was 0.5 ± 0.66 (0-2) (table I).…”

Section: Methodsmentioning

confidence: 98%

“…The suppression of autoimmune factors by prednisolone and anticoagulant therapy by low-dose aspirin was considered to improve the pathophysiology of recurrent abortion in these patients. We adopted a Chinese herbal medicine, Saireito, for the patients rather than prednisolone on the basis of the report that Saireito enhanced the effects of glucocorticoid hormones in vivo, and reported the efficacy of the treatment [6,9]. It is well known that prednisolone has many side effects, which led us to use Saireito.…”

Section: Introductionmentioning

confidence: 99%

Short communication

Takakuwa

Arakawa²,

Honda³

et al. 1997

Jpme

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Twelve women (13 pregnancies) with antiphospholipid antibodies (APA) who had suffered from two or more recurrent spontaneous abortions or fetal deaths and had successful pregnancy outcomes after immunosuppressive therapy were studied. APA titers were determined by enzyme-linked immunosorbent assay against cardiolipin, phosphatidyl serine and phosphatidyl inositol. Plasma levels of 6ketoprostaglandin F1 alpha (6ketoPGF1 alpha) and thromboxane B2 (TXB2) were determined by radioimmunoassay. All of the 13 pregnancies resulted in term delivery. None of the 13 patients suffered from pregnancy-induced hypertension, and only one showed intrauterine growth retardation. A significant decrease of APA titer was observed after immunosuppressive therapy. The 6ketoPGF1 alpha/TXB2 ratios before the therapy, after it and at the 1st, 2nd and 3rd trimesters of pregnancy were 0.62 +/- 0.398, 0.88 +/- 0.106, 0.84 +/- 0.550, 1.25 +/- 0.834 and 0.67 +/- 0.413, respectively. The ratio at the 2nd trimester was significantly higher than that before the therapy (P < 0.05, paired t-test, n = 9). The results indicate that the immunosuppressive therapy affected the physiological balance between thromboxane A2 and prostacyclin, and improved clinical symptoms such as recurrent fetal wastage.

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“…To treat the positive antiphospholipid antibodies, the Japanese traditional herbal medicine, Sairei-to (Tsumura, Tokyo, Japan; 9 g/ day), which may have a corticosteroid hormone-like pharmacological effect, 7 and low-dose aspirin (81 mg/ day) were administrated according to our previously reported protocol. [8][9][10] The titer of anticardiolipin antibody normalized after the administration of Sairei-to. The wife conceived her third pregnancy, and this pregnancy continued beyond her critical period of 10 weeks of gestation.…”

Section: Casementioning

confidence: 96%

Two cases of recurrent abortion in which isodicentric chromosome 15 was observed in the husbands

Nonaka

Ooki

Enomoto

et al. 2014

J of Obstet and Gynaecol

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We report two cases of women positive for anticardiolipin antibodies who experienced recurrent abortion whose husbands had isodicentric chromosome 15 aberrations who eventually had successful pregnancies. Two women were referred to our hospital due to their medical history of recurrent abortion. Both were diagnosed as being positive for anticardiolipin antibodies and their husbands with isodicentric chromosome 15. After both patients were treated with a Japanese herbal medicine (Sairei-to) and low-dose aspirin for the positive anticardiolipin antibodies, they delivered appropriate-for-date infants at term gestation. Although both husbands were revealed to have isodicentric chromosome 15, and coincidentally both wives were positive for anticardiolipin antibodies, their next pregnancies continued uneventfully as a result of the treatment.

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Treatment for patients with recurrent abortion with positive antiphospholipid antibodies using a traditional Chinese herbal medicine

Cited by 25 publications

References 9 publications

Anti-cardiolipin antibody and anti-cardiolipin beta-2-glycoprotein I antibody in patients with recurrent fetal miscarriage

Anti-cardiolipin antibody and anti-cardiolipin beta-2-glycoprotein I antibody in patients with recurrent fetal miscarriage

Short communication

Two cases of recurrent abortion in which isodicentric chromosome 15 was observed in the husbands

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