Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence‐based recommendations and expert opinion

Sevrain, M.; Richard, M.‐A.; Barnetche, Thomas; Rouzaud, M; Villani, Axel-Patrice; Paul, C.; Beylot‐Barry, M.; Jullien, D.; Aractingi, S.; Aubin, F.; Joly, P.; Maître, Michel; Cantagrel, A.; Ortonne, Jean‐Paul; Miséry, Laurent

doi:10.1111/jdv.12561

Cited by 59 publications

(51 citation statements)

References 11 publications

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“…For recalcitrant disease, oral retinoids, cyclosporine, methotrexate, biological agents and anakinra have been found to be useful [3,13,15,16]. Recent recommendations suggest the use of biologics only in patients with concurrent psoriatic arthritis results of the use of such agents for PPPP are conflicting, and these medications confer significant side effects including immunosuppression, bone marrow suppression and liver damage [16,17]. …”

Section: Discussionmentioning

confidence: 99%

Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature

Sheu¹,

Divito²,

Enamandram³

et al. 2015

Dermatology

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Background: Pustular psoriasis is an uncommon psoriasis variant, clinically characterized as small sterile pustules on an erythematous base. Evidence for therapy is lacking, and many currently employed systemic therapeutics carry risks of significant side effects, without specifically targeting disease etiology which includes the aggregation of neutrophils. Observations: We report therapy with the anti-neutrophil agent dapsone in 5 patients with pustular psoriasis and provide a brief review of the literature. Four patients responded to oral dapsone and 1 to topical dapsone therapy. All 5 patients had previously failed multiple topical and systemic treatments. In 2 cases, oral dapsone allowed for the discontinuation of other systemic agents. One patient stopped oral dapsone due to a side effect of sleep disturbance. Conclusion: Dapsone has a much safer side effect profile and may target the pathophysiology of pustular psoriasis more directly than many other systemic agents. As such, dapsone should be considered for the treatment of patients with pustular psoriasis.

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Section: Discussionmentioning

confidence: 99%

Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature

Sheu¹,

Divito²,

Enamandram³

et al. 2015

Dermatology

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“…Excimer‐Licht). Dieses konnte, neben der gezielten Behandlung von einzelnen Psoriasisplaques und etwas geringerer Wirkung bei der palmoplantaren pustulösen Psoriasis , auch bei der atopischen Dermatitis und der Vitiligo erfolgreich eingesetzt werden. Ebenso ist die Excimer‐Therapie bei der Alopecia areata des Erwachsenen und unter strenger Indikationsstellung bei Jugendlichen wirksam einsetzbar.…”

Section: Uv‐b‐phototherapieunclassified

S1‐Leitlinie zur UV‐Phototherapie und Photochemotherapie

Herzinger

Berneburg

Ghoreschi

et al. 2016

J Deutsche Derma Gesell

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Die heilsame Wirkung des Sonnenlichts war teilweise schon im Altertum bekannt und fand in der zweiten Hälfte des 19. Jahrhunderts wieder zunehmend Beachtung. Den Beginn der modernen Phototherapien markiert die Entwicklung einer Apparatur zur ultravioletten Bestrahlung der Hauttuberkulose durch Finnsen zu Beginn des zwanzigsten Jahrhunderts. Zur Therapie von Hauterkrankungen finden beinahe ausschließlich die spektralen Bereiche unterhalb des sichtbaren Lichtes (ultraviolett) Anwendung. Seit den 1970er Jahren stehen zunehmend leistungsfähige künstliche Strahlenquellen bereit für die Therapie mit UVB, UVA und die Kombination von UVA mit Photosensibilisatoren (Photochemotherapie). Hohe strukturelle und prozedurale Qualitätsstandards sind unabdingbare Voraussetzung für die Durchführung einer gleichermaßen wirkungsvollen wie auch sicheren Phototherapie. Die Leitlinie formuliert den aktuellen Konsens führender Experten auf dem Gebiet der Phototherapie in Bezug auf die Indikationen für die jeweiligen Therapieverfahren, deren Gegenanzeigen und Nebenwirkungen und insbesondere für die Wahl der korrekten Dosis zu Beginn und im Verlauf einer Therapie sowie das Management von Nebenwirkungen.

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“…We included patients who had been recalcitrant to other treatments, including topical corticosteroids, calcineurin inhibitors, and light therapy with an average disease duration lasting 47 months. To avoid biasing the results, patients with clinically suspected palmoplantar psoriasis were excluded from the study, as this disease has previously been shown to be responsive to excimer laser therapy . Patients were excluded based on disease morphology as well as the absence of associated skin or nail manifestations of psoriasis.…”

Section: Methodsmentioning

confidence: 99%

Use of 308 nm excimer laser for the treatment of chronic hand and foot eczema

et al. 2016

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Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence‐based recommendations and expert opinion

Abstract: Background Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis whose the association with psoriatic

Cited by 59 publications

References 11 publications

Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature

Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature

S1‐Leitlinie zur UV‐Phototherapie und Photochemotherapie

Use of 308 nm excimer laser for the treatment of chronic hand and foot eczema

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