Treatment for Alcohol Use Disorder: Progress in Predicting Treatment Outcome and Validating Nonabstinent End Points

Creswell, Kasey G.; Chung, Tammy

doi:10.1111/acer.13846

Cited by 6 publications

(4 citation statements)

References 50 publications

(74 reference statements)

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“…First, our findings suggest that changes in alcohol’s reinforcing value may serve as a motivational index of when individuals are most likely to drink and consume greater alcohol quantities, as well as when they may be less likely to drink and consume less. Prediction of alcohol use is often a goal of clinical research, both to understand development of addiction and treatment effectiveness [29]. Although conducted in a non‐clinical sample, our results indicate that in‐the‐moment assessments of alcohol demand can provide insight into motivational processes that support alcohol use disorder.…”

Section: Discussionmentioning

confidence: 84%

Alcohol demand as a predictor of drinking behavior in the natural environment

2022

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Background and Aims: Alcohol demand, a measure of alcohol's reinforcing value, is associated with greater alcohol consumption and alcohol-related problems. Although alcohol demand has primarily been evaluated as a 'trait-like', individual difference measure, recent evidence indicates that demand exhibits meaningful short-term fluctuations. We aimed to determine whether moment-to-moment fluctuations in alcohol demand in individuals' natural drinking environments predicted drinking occurrence, drinking continuation, and drinking quantity.

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Section: Discussionmentioning

confidence: 84%

Alcohol demand as a predictor of drinking behavior in the natural environment

2022

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“…Several studies have shown that moderate drinking can reduce the risk of dementia, 12,14-16 but chronic alcohol abuse will cause cognitive decline, and cognitive impairment may be restored after abstinence, indicating that nervous tissue is plastic and alcohol-induced injuries of the nervous system are often reversible. [17][18][19] In this study, MoCA was used to evaluate cognitive function. The results showed that compared with the NHD group, patients in the HD group had lower scores in visuospatial and executive function, memory, attention and the total scores of MoCA, indicating that the visuospatial and executive function, memory and attention of male patients with lacunar infarction were damaged seriously, and their cognitive function was poor.…”

Section: Discussionmentioning

confidence: 99%

<p>Contrastive Analysis of Neuropsychology and Personality Characteristics of Male Lacunar Infarction Patients with Hazardous Drinking and Non-Hazardous Drinking</p>

Yang

Qiu

Fang

2020

NDT

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Objective: To compare the differences in neuropsychological and personality characteristics between male patients with lacunar infarction with hazardous drinking and non-hazardous drinking. Methods: From May to October 2016, a total of 124 male outpatients and inpatients with lacunar infarction were selected in the Department of Neurology, Tongji Hospital, and they were divided into a hazardous drinking group (HD group, n=52) and a non-hazardous drinking group (NHD group, n=72) according to alcohol consumption habits. General information, MoCA score, EPQ score and SCL-90 score were compared between the two groups. Results: Incidence of cognitive disorder in the HD group and NHD group was 59.6% and 56.9% respectively, showing no significant difference (P>0.05). Scores of visuospatial and executive function, memory, attention and total MoCA score in the HD group were significantly lower than those in the NHD group (P<0.05), while no significant difference in naming, language, abstract thinking or orientation was found between the two groups (P>0.05). Scores of extroversion and introversion, neuroticism and psychoticism in the HD group were significantly higher than those in the NHD group (P<0.05), while no significant difference in lie or feint score was found between the two groups (P>0.05). Scores of somatization, interpersonal sensitivity, anxiety, hostility, bigotry and psychoticism factors, and total SCL-90 score in the HD group were significantly higher than those in the NHD group (P<0.05), while no significant difference in scores of obsessive-compulsive, depression and terror factors were found between the two groups (P>0.05). Conclusion: Compared with male patients with lacunar infarction with non-hazardous drinking, male lacunar infarction patients with hazardous drinking showed worse visuospatial and executive function, memory, attentiveness, cognitive function and mental health status, with more obvious change of personality, thus extra attention is needed for male lacunar infarction patients with hazardous drinking.

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“…We used alcohol‐related readmission as the primary endpoint. Although readmission represents an important problem in treatment of alcohol dependence, it is different from other relevant outcomes such as treatment dropout, relapse during treatment, and return to any alcohol use during the follow‐up (Creswell and Chung, ). We extracted readmission resulting from alcohol during the 12‐ and 24‐month observation periods in 2 important regional study centers using the electronic patient records.…”

Section: Discussionmentioning

confidence: 99%

Crossed Eye/Hand Laterality and Left‐Eyedness Predict a Positive 24‐Month Outcome in Alcohol‐Dependent Patients

Weinland

Mühle

Kornhuber

et al. 2019

Alcoholism Clin & Exp Res

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Background: Available predictors of hospital readmission following withdrawal in alcohol-dependent patients are limited. However, such parameters are needed to optimize individualized treatment strategies. This study investigated whether crossed eye/hand laterality, eyedness, and handedness may predict outcomes in alcohol dependence.Methods: The prospective study included 200 early-abstinent alcohol-dependent inpatients (n[males] = 113, n[females] = 87) and 240 control subjects (n[males] = 133, n[females] = 107). We assessed eyedness and handedness using the hole-in-the-card and Shimizu tests and documented alcohol-related readmissions over 12 and 24 months.Results: Crossed eye/hand laterality and left-eyedness were associated with a reduced risk for alcohol-related readmission (12-month: odds ratios [OR] = 0.41, p = 0.008, OR = 0.42, p = 0.004; 24month: OR = 0.57, p = 0.097, OR = 0.47, p = 0.016), fewer median readmissions (12-month: 0 vs. 1, p = 0.005, 0 vs. 1, p = 0.005; 24-month: 1 vs. 2, p = 0.014, 1 vs. 2, p = 0.006), and more mean days to the first readmission (12-month: 270 vs. 209, p = 0.007, 269 vs. 207, p = 0.003; 24-month: 462 vs. 335, p = 0.039, 461 vs. 323, p = 0.005).They also interacted with treatment and alcohol drinking history to predict the outcome. In sex-specific analyses, most of these effects remained significant in males but not in females. Handedness alone did not significantly predict outcome. Moreover, the laterality markers did not significantly differ between alcohol-dependent patients and control subjects.Conclusions: Determining crossed eye/hand laterality and eyedness may help to individualize relapse prevention in the future. Both are easily accessible predictors of alcohol-related readmission following inpatient withdrawal treatment.

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Treatment for Alcohol Use Disorder: Progress in Predicting Treatment Outcome and Validating Nonabstinent End Points

Cited by 6 publications

References 50 publications

Alcohol demand as a predictor of drinking behavior in the natural environment

Alcohol demand as a predictor of drinking behavior in the natural environment

<p>Contrastive Analysis of Neuropsychology and Personality Characteristics of Male Lacunar Infarction Patients with Hazardous Drinking and Non-Hazardous Drinking</p>

Crossed Eye/Hand Laterality and Left‐Eyedness Predict a Positive 24‐Month Outcome in Alcohol‐Dependent Patients

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