Treatment efficacy of ramucirumab-containing chemotherapy in patients with alpha-fetoprotein producing gastric cancer

Kamiimabeppu, Daisaku; Wakatsuki, Takeru; Takahari, Daisuke; Fukuda, N.; Shimozaki, Keitaro; Osumi, Hiroki; Nakayama, Izuma; Ogura, Mariko; Ooki, Akira; Shinozaki, Eiji; Chin, Keisho; Yamaguchi, Kensei

doi:10.1007/s10147-022-02263-0

Cited by 2 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Simmet et al revealed that a cisplatin-based regimen achieved a partial or complete response in 11 patients with metastatic hepatoid adenocarcinoma 44 . Kamiimabeppu et al showed that ramucirumab-containing chemotherapy resulted in a higher response and disease control rate in an AFP-positive gastric cancer group than in an AFP-negative group 45 . The authors concluded that AFP-positive gastric cancer might benefit more from this regimen.…”

Section: Discussionmentioning

confidence: 99%

High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis

Takayama-Isagawa,

Kanetaka,

Kobayashi

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Liver metastasis in gastric cancer is incurable. Alpha-fetoprotein-producing gastric cancer has a poor prognosis and is prone to liver metastasis. We investigated the association between preoperative serum alpha-fetoprotein levels, liver metastasis, and expression of primitive enterocyte phenotype markers. We reviewed the medical records of 401 patients with gastric cancer who underwent curative surgical resection and immunohistochemically evaluated the primitive phenotype markers. The preoperative serum alpha-fetoprotein levels were elevated and normal in 8 and 393 patients, respectively. Liver metastasis was more frequent in patients with higher preoperative alpha-fetoprotein levels. The 5-year postoperative recurrence-free survival and overall survival rates were significantly worse in patients with higher preoperative serum alpha-fetoprotein levels. Although alpha-fetoprotein and Glypican3 and Spalt-like transcription factor 4 tended to be stained with high preoperative serum alpha-fetoprotein levels, these markers were also positive in some patients with normal alpha-fetoprotein levels. In summary, patients with gastric cancer and high preoperative serum alpha-fetoprotein levels have a poor prognosis and high incidence of liver metastasis. Alpha-fetoprotein can help detect liver metastasis relating to the primitive enterocyte phenotype.

show abstract

Section: Discussionmentioning

confidence: 99%

High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis

Takayama-Isagawa,

Kanetaka,

Kobayashi

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

A bibliometric analysis of gastric cancer liver metastases: advances in mechanisms of occurrence and treatment options

Wang,

Zhang,

Zhang

et al. 2024

International Journal of Surgery

View full text Add to dashboard Cite

Background: Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide, and its poor prognosis is predominantly attributed to distant metastasis. Liver is the primary site of GC metastasis. However, there is no universally approved treatment regimen for liver metastasis in GC. The aim of this article is to review the current research status and trends of liver metastasis of gastric cancer worldwide. Methods: We utilized the Web of Science Core Collection database to identify articles on liver metastasis from GC published between 2000 and 2022. We used bibliometric methods to analyze authors, institutions, countries, journals, and references through CiteSpace and VOSviewer. A total of 1,003 articles were included in this study. Results: Japan published the most articles in the field, followed by China. Nagoya University is the leading institution in the field of liver metastases in GC. Yasuhiro Kodera from Japan has made significant achievements in this area. We identified Gastric Cancer to be the most influential journal in this field. Using cluster analysis, the keywords were divided into four major clusters:(1) the molecular mechanism of gastric cancer liver metastasis (2) prognosis (3) liver resection (4) chemotherapy. Conclusion: Our study systematically summarizes the results of gastric cancer liver metastasis research from 2000 to 2022 and describes and predicts research hotspots and trends on a global scale. Research on the molecular mechanisms of gastric cancer liver metastasis will become a hot topic in the future, and the expansion of the surgical treatment scope and the advancement of translational therapy will benefit more patients.

show abstract

Treatment efficacy of ramucirumab-containing chemotherapy in patients with alpha-fetoprotein producing gastric cancer

Cited by 2 publications

References 36 publications

High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis

High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis

A bibliometric analysis of gastric cancer liver metastases: advances in mechanisms of occurrence and treatment options

Contact Info

Product

Resources

About