Treatment and Outcome in 65 Children with Optic Pathway Gliomas

El-Beltagy, Mohamed; Reda, Mohamed; Enayet, Abdelrhman; Zaghloul, Mohamed S.; Awad, Madeha; Zekri, Wael; Taha, Hala; El-Khateeb, Nada

doi:10.1016/j.wneu.2016.02.042

Cited by 31 publications

(22 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,21 Nevertheless, the incidence of the different histopathological entities in our series of optic glioma hemorrhages does not seem to be very different from that in optic glioma series without hemorrhage. 11 Shibahara et al 36 suggested that optic glioma hemorrhage may be associated with NF1, as NF1 is also associated with other vascular disorders, such as moyamoya syndrome and aneurysms. However, the incidence of NF1 in this series is around 15%, which matches the normal distribution in optic glioma patients 48 and is not supportive of this hypothesis.…”

Section: Risk Factorsmentioning

confidence: 99%

Optic pathway–hypothalamic glioma hemorrhage: a series of 9 patients and review of the literature

Baarsen

Roth

Serova

et al. 2018

Journal of Neurosurgery

View full text Add to dashboard Cite

OBJECTIVE Hemorrhage (also known as apoplexy) in optic pathway gliomas (OPGs) is rare. Because of the variable presentations and low incidence of OPG hemorrhages, little is known about their clinical course and the best treatment options. The aim of this work was to review risk factors, clinical course, and treatment strategies of optic glioma hemorrhages in the largest possible number of cases. METHODS A total of 34 patients were analyzed. Nine new cases were collected, and 25 were identified in the literature. Data regarding demographics, radiological and histological features, treatment, and outcome were retrospectively reviewed. RESULTS The majority of patients were younger than 20 years. Only 3 patients were known to have neurofibromatosis. The histopathological diagnosis was pilocytic astrocytoma in the majority of cases. Five patients had intraorbital hemorrhages, whereas 29 patients had intracranial hemorrhage; the majority of intracranial bleeds were treated surgically. Six patients, all with intracranial hemorrhage, died due to recurrent bleeding, hydrocephalus, or surgical complications. No clear risk factors could be identified. CONCLUSIONS Intracerebral OPG hemorrhages have a fatal outcome in 20% of cases. Age, hormonal status, neurofibromatosis involvement, and histopathological diagnosis have been suggested as risk factors for hemorrhage, but this cannot be reliably established from the present series. The goals of surgery should be patient survival and prevention of further neurological and ophthalmological deterioration.

show abstract

Section: Risk Factorsmentioning

confidence: 99%

Optic pathway–hypothalamic glioma hemorrhage: a series of 9 patients and review of the literature

Baarsen

Roth

Serova

et al. 2018

Journal of Neurosurgery

View full text Add to dashboard Cite

show abstract

“…OPGs are more common in children, and many centers have conducted retrospective studies (19,20). Although chemotherapy had good results on patients with vision preservation, the patients in our center had already suffered from severe visual loss or even blindness when they came to the clinic.…”

Section: Discussionmentioning

confidence: 82%

Comparison of two surgical methods for the treatment of optic pathway gliomas in the intraorbital segment: an analysis of long-term clinical follow-up, which evaluates the surgical outcomes

Yang¹,

Liu²,

Qiu³

et al. 2021

Transl Pediatr

View full text Add to dashboard Cite

Background: This study analyzes two kinds of surgical methods for the treatment of optic pathway gliomas (OPGs) in the intraorbital segment, as well as the surgical outcomes of OPGs. Methods:The clinical data of 86 patients with OPGs treated in our center was analyzed retrospectively, and the clinical symptoms, treatment methods, and follow-up results were recorded.Results: For OPGs in the intraorbital segment, the optic nerve sheath incision was performed to remove a tumor while retaining the optic nerve sheath in Group 1 (n=36).The optic nerve sheath and the tumor were simultaneously removed without retaining the optic nerve sheath in group 2 (n=50). The effects of the design of the surgical methods on the post-surgical outcome are: One patient (1/36, 2.8%) had recurrence in Group 1 and one patient (1/50, 2.0%) had recurrence in group 2. The differences in the surgical outcomes of the two groups regarding exophthalmos, conjunctiva swelling, eye movement disorder, and ptosis were found to be statistically significant (P<0.05). Compared with group 2, the surgical outcomes in the postoperative phase of Group 1 were more satisfactory. Conclusions:The two surgical methods do not increase the recurrence rate of tumors. The resection of OPGs through an optic nerve sheath incision was found to be an ideal surgical method for reducing complications in the postoperative phase and for providing better surgical outcomes.

show abstract

“…In a multicenter retrospective analysis of the visual outcome in children with NF-type 1-associated optic pathway glioma following chemotherapy, Fisher et al 17 reported that approximately a third of the children regained partial vision. According to El Beltagy et al, 18 chemotherapy reduces or stabilizes the size of the tumor in most cases and leads to preservation of vision and endocrine functions. However, the use of chemotherapy is limited by its unfavorable hypersensitivity reactions.…”

Section: Discussionmentioning

confidence: 99%

“…8,19 The role of surgery for newly diagnosed ONG is to obtain a biopsy for histologic diagnosis and treatment of hydrocephalus, if any, followed by chemotherapy. 18 Most patients with ONG demonstrate slow and even prolonged asymptomatic tumor growth with survival close to 100%. Liu 28 advocated a conservative approach unless a clear progression of the disease is observed.…”

Section: Discussionmentioning

confidence: 99%

Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1

Surchev

Nachev

Todorova

et al. 2018

J Neurol Surg A Cent Eur Neurosurg

View full text Add to dashboard Cite

Optic nerve glioma (ONG) is associated in 10% of patients with neurofibromatosis (NF) type 1. To date no consensus has been reached regarding the therapeutic approach and prevention of visual impairment in these patients. Reports in the literature vary from a conservative approach (observation) to the use of single treatment modalities or multimodality protocols of surgical removal, radiotherapy, and/or chemotherapy. We present our experience with two siblings with ONG whose mother carries cutaneous stigmata of NF type 1. The younger sister was diagnosed 3 years after the treatment of the older sibling following recommended imaging for screening. Postoperative follow-up for 11 and 15 years, respectively, demonstrated lack of tumor regrowth and preserved vision in the contralateral eye. We discuss the treatment strategy in pediatric patients with orbital ONG associated with NF type 1.

show abstract

Treatment and Outcome in 65 Children with Optic Pathway Gliomas

Cited by 31 publications

References 26 publications

Optic pathway–hypothalamic glioma hemorrhage: a series of 9 patients and review of the literature

Optic pathway–hypothalamic glioma hemorrhage: a series of 9 patients and review of the literature

Comparison of two surgical methods for the treatment of optic pathway gliomas in the intraorbital segment: an analysis of long-term clinical follow-up, which evaluates the surgical outcomes

Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1

Contact Info

Product

Resources

About