Treating tumors with minimally invasive therapy: A review

Wang, Ping; Sun, Shijie; Ma, Huide; Sun, Shaodong; Zhao, Danyang; Wang, Shumin; Liang, Xiaolong

doi:10.1016/j.msec.2019.110198

Cited by 31 publications

(27 citation statements)

References 253 publications

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“…Cancers are chronologic diseases that seriously threaten human life. Many strategies have been developed for cancer treatment, including chemotherapy, radiotherapy, surgery, and targeted therapy, which are found to be effective for some malignant tumors ( 1 , 2 ). However, metastasis, recurrence, heterogeneity, resistance to chemotherapy and radiotherapy, and avoidance of immunological surveillance are the most common reasons for cancer treatment failure.…”

Section: Introductionmentioning

confidence: 99%

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Hua

Gan

et al. 2021

Front. Oncol.

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Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer. Both therapies, on their own, have some limitations and are incapable of meeting the demands of the current cancer treatment. The efficacy of PDT and immunotherapy against tumor metastasis and tumor recurrence may be improved by combination strategies. In this review, we discussed the possibility that PDT could be used to activate immune responses by inducing immunogenic cell death or generating cancer vaccines. Furthermore, we explored the latest advances in PDT antitumor therapy in combination with some immunotherapy such as immune adjuvants, inhibitors of immune suppression, and immune checkpoint blockade.

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Section: Introductionmentioning

confidence: 99%

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Hua

Gan

et al. 2021

Front. Oncol.

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“…Cancer, as one of the most intractable diseases, has spoiled millions of lives due to its high morbidity and mortality. 1,2 Over the past decades, great efforts have been focused on the development of efficient therapeutics for cancer treatment, such as surgery, 3 radiotherapy, 4,5 chemotherapy, 6,7 photodynamic therapy (PDT), [8][9][10] photothermal therapy (PTT) [11][12][13] and immunotherapy. [14][15][16] In particular, PTT has attracted extensive attention due to its inherent advantages of minimal invasion and external light control.…”

Section: Introductionmentioning

confidence: 99%

Dual-targeted photothermal agents for enhanced cancer therapy

et al. 2020

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“…Malignant tumor metastasis is usually the leading cause of death in cancer patients [ 1 ]. Breast cancer is a multistate tumor that often has fatal effects by metastasizing to distant organs, such as bones, lungs, and liver [ 2 – 4 ].…”

Section: Introductionmentioning

confidence: 99%

CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin

Shi²,

Liu

et al. 2020

Cancer Cell Int

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Background CD44 is highly expressed in most cancer cells and its cross-linking pattern is closely related to tumor migration and invasion. However, the underlying molecular mechanism regarding CD44 cross-linking during cancer cell metastasis is poorly understood. Therefore, the purpose of this study was to explore whether disruption of CD44 cross-linking in breast cancer cells could prevent the cells migration and invasion and determine the effects of CD44 cross-linking on the malignancy of the cancer cells. Methods The expression of CD44, CD44 cross-linking and Moesin phosphorylation in breast cancer cells was assessed by Western Blot assays. Effects of CD44 cross-linking on tumor metastasis were evaluated by Transwell assay. The effects of CD44 cross-linking disruption on cell viability were assessed using CCK-8 assays. The expression of p-Moesin between normal and breast cancer tissues was examined by immunohistochemical staining. Results High expression of CD44 cross-linking was found in invasive breast cancer cells (BT-549 and MDA-MB-231), which is associated with the malignancy of breast cancer. The expressions of ERM complex in a panel of breast cancer cell lines indicate that Moesin and its phosphorylation may play a significant role in cell metastasis. Moesin phosphorylation was inhibited by CD44 de-crosslinking in breast cancer cells and Moesin shRNA knockdown attenuated the promotion of CD44 cross-linking on cell migration and invasion. Finally, immunohistochemistry results demonstrated that p-Moesin was overexpressed in primary and metastatic cancers. Conclusions Our study suggested that CD44 cross-linking could elevate p-Moesin expression and further affect migration and invasion of breast cancer cells. These results also indicate that p-Moesin may be useful in future targeted cancer therapy.

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Treating tumors with minimally invasive therapy: A review

Cited by 31 publications

References 253 publications

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Dual-targeted photothermal agents for enhanced cancer therapy

CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin

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