Dual-targeted photothermal agents for enhanced cancer therapy

Wang, Kaiye; Xiang, Yanan; Pan, Wei; Wang, Hongyu; Li, Na; Tang, Bo

doi:10.1039/d0sc03173a

Cited by 72 publications

(38 citation statements)

References 122 publications

(120 reference statements)

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“…These factors indicated the worse NIR-II fluorescence imaging, which helped to improve the photothermal conversion capability of NIR998 NPs. The results were similar to previous works [ 33 – 35 ]. The strong NIR light capture capability and negligible emission of NIR998 NPs indicate promising photoacoustic imaging (PAI), photothermal imaging, and tumor photothermal therapy capabilities.…”

Section: Resultssupporting

confidence: 92%

Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment

Wang

Chen

et al. 2021

J Nanobiotechnol

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Background The aim to develop a highly stable near-infrared (NIR) photoinduced tumor therapy agent stems from its considerable potential for biological application. Due to its long wavelength, biological imaging exhibits a high signal-to-background ratio, deep tissue penetration and maximum permissible light power, which can minimize damage to an organism during photoinduced tumor therapy. Results A class of stable NIR-II fluorophores (NIR998, NIR1028, NIR980, NIR1030, and NIR1028-S) based on aza–boron–dipyrromethene (aza-BODIPY) dyes with donor–acceptor-donor structures have been rationally designed and synthesized by harnessing the steric relaxation effect and intramolecular photoinduced electron transfer (IPET). These fluorophores exhibit an intense range of NIR-II emission, large Stokes shift (≥ 100 nm), excellent photothermal conversion performance, and superior stability against photobleaching. Among the NIR-II fluorophores, NIR998 possesses better NIR-II emission and photothermal conversion performance. NIR998 nanoparticles (NIR998 NPs) can be encapsulated by liposomes. NIR998 NPs show superior stability in the presence of light, heat, and reactive oxygen nitrogen species than that of indocyanine green NPs, as well as a higher photothermal conversion ability (η = 50.5%) compared to other photothermal agents. Finally, under the guidance of photothermal imaging, NIR998 NPs have been proven to effectively eliminate tumors via their excellent photothermal conversion performance while presenting negligible cytotoxicity. Conclusions Utilizing IPET and the steric relaxation effect can effectively induce NIR-II emission of aza-BODIPY dyes. Stable NIR998 NPs have excellent photothermal conversion performance and negligible dark cytotoxicity, so they have the potential to act as photothermal agents in biological applications.

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Section: Resultssupporting

confidence: 92%

Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment

Wang

Chen

et al. 2021

J Nanobiotechnol

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“…[ 30 ] In addition to utilizing the hydrophilicity of biomolecules, some biomolecules in vivo can specifically bind to overexpressed proteins on the membrane surface of cancer cells, thus have the function of targeting cancer cells, such as hyaluronic acid (HA) and cyclic RGD which could be used for targeting the CD44 and α v β 3 integrin, respectively. [ 31 ]…”

Section: Single‐component Sanpsmentioning

confidence: 99%

“…HA and cyclic RGD are often used as targeting species introduced to the drugs for targeting the excessively expressed CD44 and α v β 3 integrin, respectively. [ 31 ] In addition to targeting proteins that are overexpressed on the membrane surface of cancer cells, developing novel drugs with the ability of targeting subcellular organelles including mitochondria, nucleus, or endoplasmic reticulum (ER) is also attractive and meaningful. And many biomaterials could be used for targeting subcellular organelles, such as nuclear localization sequence (NLS) peptides, mitochondria localization (MLS) peptides, and pardaxin (FAL) peptides, which could target the nucleus, mitochondria, and ER, respectively.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

“…And many biomaterials could be used for targeting subcellular organelles, such as nuclear localization sequence (NLS) peptides, mitochondria localization (MLS) peptides, and pardaxin (FAL) peptides, which could target the nucleus, mitochondria, and ER, respectively. [ 31 ] ii) Further studies should be conducted on the approved drugs and the safety of nanomedicines then also should be investigated to promote the clinical transformation. It only makes great sense to complete the transformation from laboratory to factory to clinic.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

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Self‐Assembled Nanoparticles as Cancer Therapeutic Agents

Wang

Zhang

et al. 2020

Adv Materials Inter

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Most therapeutic agents for cancer are currently suffering from the shortcomings of poor solubility, severe side effects, and multidrug resistance. Supramolecular self‐assembly (SSA) in nanomedicines is a promising way to overcome these obstacles due to the distinguished properties of noncovalent self‐assembly such as functional diversity, easy stimulus‐response, high biocompatibility, and biodegradability. Moreover, it is more potential to transform them from lab to clinic. In this review, based on lots of state‐of‐the‐art studies, a summary is presented about the recent advances in SSA for cancer treatment, with the introduction of noncovalent driving forces, classifications, design, and applications of multifunctional self‐assembled nanoparticles (SANPs). Finally, the prospects of SANPs on both developing drugs and clinical transformation are discussed.

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“…PTT can kill cancer cells and bacterial biofilm via heat energy generated by photothermal agents under NIR laser irradiation. [9][10][11][12][13][14][15] In recent years, various inorganic nanomaterials have been actively employed for photothermal therapy of tumors, including gold nanoparticles, 16 carbon nanomaterials, 17 palladium nanosheets, 18 and transitional metal dichalcogenide. 19,20 Although superior efficiency in ablation tumors has been achieved by using inorganic photothermal agents, the potential long-term toxicity and poor biodegradation remain the major challenges.…”

Section: Introductionmentioning

confidence: 99%

An Acceptor-π-Donor Structured Organic Chromophore for NIR Triggered Thermal Ablation of Tumor via DNA Damage-Mediated Apoptosis

Zhang

Yang

Liu

et al. 2021

IJN

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Introduction: It will be challenging to develop high-performance organic chromophores for light-triggered thermal ablation of the tumor. Besides, the mechanisms of organic chromophores for tumor therapy remain unclear. Herein, an acceptor-π-donor (A-π-D) structured organic chromophore based on 2-dicyanomethylenethiazole named PTM was developed for photothermal therapy (PTT) of tumors. Methods and Results: Biocompatible PTM nanoparticles (PTM NPs) were fabricated by enclosing PTM with Pluronic F-127. The results of optical and photothermal properties of PTM NPs showed robust near-infrared (NIR) absorption, excellent photostability and high photothermal conversion efficiency (56.9%). The results of flow cytometry, fluorescence microscopy, apoptosis, CCK-8 assays and animal experiments showed that PTM NPs had a good killing effect on tumors under NIR laser irradiation. Furthermore, mechanistic studies, RNA-seq and biological analysis revealed that PTM NPs can cause tumor cell death via DNA damage-mediated apoptosis. Conclusion: Light-induced thermal ablation effects of PTM NPs in vitro and vivo were surveyed. Collectively, our studies provided a new approach to developing a safe and effective photothermal agent for cancer treatment.

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Dual-targeted photothermal agents for enhanced cancer therapy

Abstract: Photothermal therapy, which converts light into heat and triggers local hyperthermia to ablate tumor, presents an inherently specific and noninvasive treatment for tumor tissues. In which, the development of efficient...

Cited by 72 publications

References 122 publications

Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment

Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment

Self‐Assembled Nanoparticles as Cancer Therapeutic Agents

An Acceptor-π-Donor Structured Organic Chromophore for NIR Triggered Thermal Ablation of Tumor via DNA Damage-Mediated Apoptosis

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