Treating skin cancer with topical cream

Micali, Giuseppe; Lacarrubba, Francesco; Dinotta, Franco; Massimino, Doriana; Nasca, Maria Rita

doi:10.1517/14656566.2010.481284

Cited by 43 publications

(52 citation statements)

References 87 publications

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“…E-selectin is a cell adhesion protein important for the extravasation of inflammatory cells, and may be important for enabling anti-tumour responses. Although these mechanisms have not been as extensively studied in actinic keratosis and superficial BCC, short-term clearance following imiquimod treatment has been demonstrated 199–201 suggesting that in some circumstances, recruitment of an appropriate inflammatory response can result in tumour clearance. Intralesional IFN-α-2b, another immune agonist, also has activity against BCC and SCC 202,203 .…”

Section: Immunotherapymentioning

confidence: 99%

Roles of the immune system in skin cancer

Rangwala

Tsai

2011

British Journal of Dermatology

163

147

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Over the past several decades, there has been increasing interest in understanding the roles of the immune system in the development and progression of cancer. The importance of the immune system in human skin cancer has been long recognised based primarily upon the increased incidence of skin cancers in organ transplant recipients and mechanisms of ultraviolet light-mediated immunomodulation. In this review, we integrate multiple lines of evidence highlighting the roles of the immune system in skin cancer. First, we discuss the concepts of cancer immunosurveillance and immunoediting as they might relate to human skin cancers. We then describe the clinical and molecular mechanisms of skin cancer development and progression in the contexts of therapeutic immunosuppression in organ transplant recipients, viral oncogenesis, and ultraviolet light-induced immunomodulation with a primary focus on basal cell carcinoma and squamous cell carcinoma. The clinical evidence supporting expanding roles for immunotherapy is also described. Finally, we discuss recent research examining the functions of particular immune cell subsets in skin cancer and how they might contribute to both anti-tumour and pro-tumour effects. A better understanding of the biological mechanisms of cancer immunosurveillance holds the promise of enabling better therapies.

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Section: Immunotherapymentioning

confidence: 99%

Roles of the immune system in skin cancer

Rangwala

Tsai

2011

British Journal of Dermatology

163

147

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“…Consequentially, this has led to the development of a variety of pharmacologic alternatives, including topical therapies. In particular, topical pharmacotherapy is considered an interesting approach in selected skin alterations, being a noninvasive and selfadministered treatment, and, in particular, it represents a highly desirable alternative option in patients with lesions located on cosmetically sensitive areas (Micali et al, 2010). Celecoxib (CXB) is a non-steroidal anti-inflammatory drug (NSAID) selective cyclooxygenase-2 (COX-2) inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib

et al. 2012

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Topical administration of celecoxib proved to be an effective mean of preventing skin cancer development and improving anticancer drugs effectiveness in skin tumors treatment. The aim of this study was the development of an effective topical formulation of celecoxib, able to promote drug skin delivery, providing its in depth penetration through the skin layers. Three kinds of vesicular formulations have been investigated as drug carriers: liposomes containing a surfactant, or transfersomes and ethosomes, containing suitable edge activators. Firstly, the effect of membrane composition variations on the system performance has been evaluated for each vesicle type. Selected formulations were characterized for particle size, polydispersity index and encapsulation efficiency. The best formulations were subjected to ex vivo permeation studies through excised human skin. All vesicular formulations markedly (p < 0.001) improved the drug amount penetrated into the skin with respect to an aqueous suspension, from 2.0 to 6.5, up to 9.0 folds for liposomes, transfersomes and ethosomes, respectively. In particular, ethosomes containing Tween 20 as edge activator not only showed the best vesicle dimensions and homogeneity, and the highest encapsulation efficacy (54.4%), but also enabled the highest increase in drug penetration through the skin, probably due to the simultaneous presence in their composition of ethanol and Tween 20, both acting as permeation enhancers. Therefore, among the various vesicular formulations examined in the study, Tween 20-ethosomes can be considered the most promising one as carrier for topical celecoxib applications aimed to prevent skin cancer development and increase the anticancer drugs effectiveness against skin tumors.

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“…Diagnosis of lentigo maligna (LM) on the face is often challenging because of the overlap of clinical and morphologic features with other lesions, such as solar lentigo, flat seborrheic keratosis, pigmented actinic keratosis and, less likely, pigmented basal cell carcinoma (BCC). 1,2 In recent years, topical treatment options [3][4][5][6][7][8] for many of these conditions have emerged, and are particularly helpful in treatment of facial lesions for cosmetic reasons. In view of this, there is an increasing demand for a noninvasive diagnostic aid for treatment management.…”

mentioning

confidence: 99%