Treating metastatic sarcomas locally: A paradoxe, a rationale, an evidence?

Olivier, Timothée; Pop, Dániel; Djebaili, Amina Chouiter; Falk, Alexander Tuan; Iannessi, Antoine; Saâda, Esma; Nettekoven, Willy; Blay, Jean‐Yves; Baqué, Patrick; Cupissol, Didier; Thyss, A.; Thariat, Juliette

doi:10.1016/j.critrevonc.2015.01.004

Cited by 16 publications

(27 citation statements)

References 118 publications

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“…Authors conclude that local ablative treatment of oligometastatic diseases seems to improve the overall survival. Surgery yielded the most relevant results, but alternative approaches (radiofrequency ablation and radiotherapy) seemed to be promising . Our results suggest that local treatments (neurosurgical resection, WBRT, stereotactic radiotherapy) improve the outcome of adult sarcoma patients with BM.…”

Section: Discussionmentioning

confidence: 74%

“…The role of local treatments in the context of metastatic spreading is difficult to establish without randomized study data. However, several studies seem to show a positive impact of surgery, particularly on lung metastases . A meta‐analysis of 18 publications reported OS 5‐year rates of 25% for metastatic bone and 15% for metastatic soft tissue sarcomas, with corresponding 5‐year rates of 34% and 25% for patients undergoing a first pulmonary metastasectomy .…”

Section: Discussionmentioning

confidence: 99%

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Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO)

et al. 2018

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The incidence of brain and meningeal metastasis in bone and soft tissue sarcomas is estimated between 1% and 8%. Published data are derived from small retrospective case series, often in the pediatric population. A prognostic index is important to guide both clinical decision-making and outcomes research, but one such is lacking for adult sarcoma patients with brain metastases. The current study describes brain metastasis in a large cohort of sarcoma patients. This study, conducted within the French Sarcoma Group, describes the natural history of sarcoma brain metastasis and enables the proposal of strategic recommendations for subsequent clinical trials and for the management of such patients.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO)

et al. 2018

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“…Surgical resection is the main treatment method for patients with lung metastases from bone and soft tissue tumors. The three and five‐year survival rates of surgical resection range from 25–54% and 14–25%, respectively, but only 25–30% of patients are operable and 40–80% patients will develop recurrence . Although reoperation has been proven effective for controlling tumor recurrence, not all patients are able to tolerate reoperation.…”

Section: Ablation Therapy Of Lung Metastases From Bone and Soft Tissumentioning

confidence: 99%

Value of ablation therapy in the treatment of lung metastases

Fan

2017

Thoracic Cancer

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Tumor metastases are the basic biological characteristics of malignant tumors, and the lungs are the second most prominent metastatic organs in which these develop after the liver. Currently, with the rapid development of ablation technology, ablation therapy as a local treatment is playing an increasingly important role in the treatment of lung metastases. Whether alone or in combination with other treatments, ablation therapy has achieved good therapeutic effects for the treatment of partial lung metastases. This article briefly summarizes the results of current and previous ablation treatments for lung metastases, and focuses on the value of ablation therapy for different kinds of lung metastases.

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“…Traitement focal de métastases de sarcomes oligométastatiques (Figs 9, 10) La question du traitement focal des sarcomes oligométasta-tiques doit être évoquée dès lors que cela semble techniquement réalisable [18]. Le meilleur exemple, bien que fondé sur des études rétrospectives, est fourni par l'expérience de résection chirurgicale de métastases pulmonaires sur des formes oligométastatiques de sarcomes : une résection complète des lésions oligométastatiques après un long intervalle libre est directement corrélée à une amélioration de la survie.…”

Section: Introductionunclassified

Radiologie interventionnelle et tumeurs des tissus mous : du diagnostic au traitement

et al. 2016

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Reçu le 24 novembre 2015 ; accepté le 4 avril 2016 © Lavoisier SAS 2016Résumé La radiologie interventionnelle joue un rôle clé pour la prise en charge des tumeurs des tissus mous. D'abord au stade diagnostique par la réalisation de biopsies ciblées ; ces biopsies doivent répondre aux guides de bonnes pratiques dictées par les sociétés savantes internationales, dont nous rappelons les points clés. Ensuite, au stade thérapeu-tique, grâce aux techniques d'ablathermie (radiofréquence, cryothérapie) pour des indications très spécifiques. Ces procédures peuvent s'envisager en traitement de rattrapage sur la tumeur primaire, sur certaines récidives postchirurgie et radiothérapie ; elles peuvent aussi être proposées sur des formes oligométastatiques de sarcomes ; enfin, elles peuvent être indiquées en première ligne de traitement focal sur certaines tumeurs bénignes à agressivité locale telles qu'héman-giomes agressifs ou tumeurs desmoïdes. La radiologie interventionnelle vient renforcer l'arsenal thérapeutique en oncologie. Une approche multidisciplinaire reste indispensable pour sélectionner les meilleures indications.Mots clés Radiologie interventionnelle · Biopsie · Radiofréquence · Cryothérapie · Tumeurs des tissus mous · Sarcome · Oligométastases · Tumeur desmoïde Abstract Interventional radiology plays an increasing role in the management of soft tissue tumors. For initial diagnosis, precise and safe image-guided biopsies; soft tissue tumor biopsies must be performed in accordance with international guidelines. Then, in a therapeutic phase, interventional radiology, particularly with thermal ablation techniques (radiofrequency, cryoablation), can be proposed for specific indications like salvage treatment of recurrent tumor after surgery and radiotherapy, focal ablation for oligometastatic sarcomas, or treatment of benign locally aggressive tumors such as symptomatic hemangiomas or desmoid tumors. A multidisciplinary approach remains mandatory to achieve optimal patient selection for interventional radiology techniques.

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Treating metastatic sarcomas locally: A paradoxe, a rationale, an evidence?

Cited by 16 publications

References 118 publications

Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO)

Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO)

Value of ablation therapy in the treatment of lung metastases

Radiologie interventionnelle et tumeurs des tissus mous : du diagnostic au traitement

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