Treating acne vulgaris: systemic, local and combination therapy

Savage, Laura; Layton, Alison

doi:10.1586/ecp.10.27

Cited by 36 publications

(76 citation statements)

References 157 publications

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“…The SASA group recommends that the duration of oral and topical antibiotic treatment of acne vulgaris should be less than 12 weeks, with good compliance to treatment. This is a reasonable duration between the minimum of more than 3 weeks (the amount of time by which antibiotic treatment typically produces an observable improvement) and 6–8 weeks (when a reasonable assessment of the efficacy of oral antibiotics can be performed) and the maximum of 8–16 weeks after initiation of antibiotic therapy when a patient should be suspected of antibiotic resistance . The SASA recommends that the response to treatment may be assessed every 8–12 weeks.…”

Section: Discussionmentioning

confidence: 99%

South‐East Asia study alliance guidelines on the management of acne vulgaris in South‐East Asian patients

Goh

Abad-Casintahan

et al. 2015

The Journal of Dermatology

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The management of acne in South-East Asia is unique, as Asian skin and local variables require a clinical approach unlike that utilized in other parts of the world. There are different treatment guidelines per country in the region, and a group of leading dermatologists from these countries convened to review these guidelines, discuss current practices and recent advances, and formulate consensus guidelines to harmonize the management of acne vulgaris in the region. Emphasis has been placed on formulating recommendations to impede the development of antibiotic resistance in Propionibacterium acnes. The group adopted the Acne Consensus Conference system for grading acne severity. The group recommends that patients may be treated with topical medications including retinoids, benzoyl peroxide (BPO), salicylic acid, a combination of retinoid and BPO, or a combination of retinoids and BPO with or without antibiotics for mild acne; topical retinoid with topical BPO and a oral antibiotic for moderate acne; and oral isotretinoin if the patient fails first-line treatment (a 6-or 8-week trial of combined oral antibiotics and topical retinoids with BPO) for severe acne. Maintenance acne treatment using topical retinoids with or without BPO is recommended. To prevent the development of antibiotic resistance, topical antibiotics should not be used as monotherapy or used simultaneously with oral antibiotics. Skin care, comprised of cleansing, moisturizing and sun protection, is likewise recommended. Patient education and good communication is recommended to improve adherence, and advice should be given about the characteristics of the skin care products patients should use.

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Section: Discussionmentioning

confidence: 99%

South‐East Asia study alliance guidelines on the management of acne vulgaris in South‐East Asian patients

Goh

Abad-Casintahan

et al. 2015

The Journal of Dermatology

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“…An holistic approach to therapy should be taken that combines standard treatments with adjunct therapy and cosmetic use, and considers the specific characteristics of the adult female. Choice of therapy should also be determined by various other factors including the extent, severity and duration of the disease, response to previous treatments and predisposition to scarring and post‐inflammatory hyperpigmentation (PIH), as well as patient preference and cost 18,19 …”

Section: Adult Female Acne Therapymentioning

confidence: 99%

“…A summary of recommendations for acne therapy in the adult female are provided in Table 2. A comprehensive assessment of the patient’s condition should be performed, including taking a personal history and conducting a physical examination 18 …”

Section: Adult Female Acne Therapymentioning

confidence: 99%

Adult female acne: a new paradigm

Dréno¹,

Layton

Zouboulis

et al. 2013

Acad Dermatol Venereol

166

167

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In the adult female, acne is a chronic condition with a substantial negative psychological, social and emotional impact. Based on time of onset, two subtypes of adult female acne are recognized: 'persistent acne' is a continuation of the disease from adolescence, while 'late-onset acne' first presents in adulthood. The morphological characteristics of adult female acne are often distinct from adolescent acne. In adults, inflammatory lesions (particularly papules, pustules and nodules) are generally more prominent on the lower chin, jawline and neck, and comedones are more often closed comedones (micro cysts). Adult acne is mainly mild-to-moderate in severity and may be refractory to treatment. A holistic approach to acne therapy should be taken in adult females, which combines standard treatments with adjunctive therapy and cosmetic use. A number of factors specific to the adult female influence choice of treatment, including the predisposition of older skin to irritation, a possible slow response to treatment, a high likelihood of good adherence, whether of child-bearing age, and the psychosocial impact of the disease. Adherence to therapy should be encouraged through further patient education and a simplified regimen that is tailored to suit the individual patient's needs and lifestyle. This article reviews the specific characteristics of adult female acne, and provides recommendations for acne therapy in this patient group.

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“…The above factors may predispose certain individuals to suffer from postadolescent acne, but there are no differences in the skin microbiology of patients with adolescent, persistent or late-onset acne that could account for these various forms of acne [6,33]. …”

Section: Pathophysiological Characteristics Of Postadolescent Acnementioning

confidence: 99%

Postadolescent Acne in Females

Holzmann

Shakery

2013

Skin Pharmacol Physiol

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Acne in the adult female often presents as a chronic condition that can have a considerable negative psychological, social and emotional impact on the affected individual. Estimated prevalence rates of adult female acne vary widely according to study type. Case reports and clinical examinations estimate the prevalence of clinical acne at 10-12%, while survey estimates of physiological disease states are as high as 54%. Two subtypes of adult female acne may be defined according to time of onset: ‘persistent' and ‘late-onset', accounting for approximately 80 and 20% of cases, respectively. Postadolescent acne is generally mild-to-moderate in severity and presents with more inflammatory lesions and fewer comedones compared to adolescent acne. Furthermore, the impact of acne on the quality of life is often greater in adult females than in younger individuals. Despite these important differences, the key principles of acne treatment in the adult female do not differ significantly from those of other age groups. However, specific characteristics relating to the adult female should be considered when selecting a treatment regimen.

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Treating acne vulgaris: systemic, local and combination therapy

Cited by 36 publications

References 157 publications

South‐East Asia study alliance guidelines on the management of acne vulgaris in South‐East Asian patients

South‐East Asia study alliance guidelines on the management of acne vulgaris in South‐East Asian patients

Adult female acne: a new paradigm

Postadolescent Acne in Females

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