Treadmill Exercise Modulates Intestinal Microbes and Suppresses LPS Displacement to Alleviate Neuroinflammation in the Brains of APP/PS1 Mice

Yuan, Shunling; Yang, Jialun; Jian, Ye; Lei, Yong; Yao, Sisi; Hu, Zhengyan; Liu, Xia; Tang, Changfa; Liu, Wenfeng

doi:10.3390/nu14194134

Cited by 33 publications

(19 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the neutral bacterium Prevotella was positively associated with mucin synthesis, which increases intestinal permeability and is an important condition for MA, leading to pro-inflammatory effects [ 24 ]. Several studies have shown that exercise can reduce the abundance of such bacteria and maintain intestinal health [ 58 , 59 , 60 ]. The current study also found that Alloprevotella rose after MA administration and fell after exercise intervention.…”

Section: Discussionmentioning

confidence: 99%

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Liang

Jin

et al. 2023

Metabolites

View full text Add to dashboard Cite

This study aimed to investigate the changes in intestinal homeostasis and metabolism in mice after methamphetamine (MA) administration and exercise intervention. In this study, male C57BL/B6J mice were selected to establish a model of methamphetamine-induced addiction, and the gut microbiota composition, short-chain fatty acids (SCFAs), and amino acid levels were assessed by 16S rRNA, liquid chromatography–tandem mass spectrometry, and gas chromatography–tandem mass spectrometry, respectively. The results showed that 23 dominant microbiota, 12 amino acids, and 1 SCFA were remarkably higher and 9 amino acids and 6 SCFAs were remarkably lower in the exercise model group than in the control group. Among the top 10 markers with opposite trends between the exercise intervention group and model group, the differential microbiomes included Oscillibacter, Alloprevotella, Colidextribacter, Faecalibaculum, Uncultured, Muribaculaceae, and Negativibacillus; amino acids included proline; and SCFAs included isovaleric acid and pentanoic acid. Proline was negatively correlated with Negativibacillus and positively correlated with pentanoic acid. The results suggested that moderate-intensity aerobic exercise may modulate changes in the composition of the gut microbiota and the levels of amino acids and SCFAs induced by MA administration.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Liang

Jin

et al. 2023

Metabolites

View full text Add to dashboard Cite

show abstract

“…The MICT protocol was performed as previously reported [29] . From week 1 to 8, the mice performed incremental aerobic exercises starting at 7 m/min and increasing to 14 m/min (Fig.…”

Section: Exercise Protocolmentioning

confidence: 99%

Moderate-intensity continuous training and high-intensity interval training modulate gut microbes, and weaken leaky gut-immune activation reduces systemic inflammation in high-fat diet APOE-KO mice

tang,

Wang,

Wang

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Atherosclerosis is a common disease typically associated with the dysregulation of inflammatory pathways and lipid metabolism. Regular exercise can prevent and delay atherosclerosis-related dysfunctions; however the effects of different types of exercise on atherosclerosis and their underlying molecular mechanisms remain unclear. Based on the evidence of intestinal microbiota dysbiosis and impaired intestine-liver-brain axis in APOE-knockout (KO) mice, we found plasma lipid profile abnormalities, intestinal microbiota imbalance, intestinal inflammation, liver inflammation, bacterial lipopolysaccharide displacement, and neuroinflammation in APOE-KO mice fed a high-fat diet. Our experimental findings indicate that following a twelve-week intervention of moderate-intensity continuous training and high-intensity interval training interventions, alterations in the gut microbiota and improvements in the damaged gut-liver-brain axis were partially associated with the beneficial effects of exercise. demonstrating that both forms of exercise effectively reduce body weight and lipid profiles associated with hyperlipidemia in APOE-KO mice, while promoting stability in the gut microbiota of these mice, thereby inhibiting the expression of inflammatory signaling pathways. It is noteworthy that exercise downregulates LPS, retards intestinal leakage and brain leakage in mice, thereby alleviating systemic inflammation linked closely with the TLR4/MyD88/NF-KB inflammatory signaling pathway. The mechanism involves MICT and HIIT reinforcing the gut-liver and gut-brain barriers against LPS interception, weakening LPS translocation to the internal milieu, inhibiting the liver and brain TLR4/MyD88/NF-κB inflammatory signaling pathways, and alleviating systemic inflammation in APOE-KO mice. Particularly, HIIT demonstrates superior improvement in plasma lipid profiles in APOE-KO mice compared to MICT.

show abstract

“…Running exercise has also been shown to increase the microbial content of Eubacteria , Roseburia , and Clostridia in the intestines of APP/PS1 mice, while decreasing the abundance of Prevotella , Bacteroides , Bacteroides fragilis , and L. johnsonii . This alteration inhibits the transfer of LPS to the brain, thereby alleviating LPS-induced neuroinflammation and improving cognitive function and pathological markers in AD mice [ 273 , 275 ]. Moreover, voluntary wheel running (VWR) exercise has been found to upregulate the abundance of phylum Bacteroidetes and genus Prevotella while reducing the abundance of phylum Actinobacteria and TM7 , as well as genus Oscillospira and Ruminococcus .…”

Section: Molecular Mechanisms Of Gut Microbiota Regulation Of Ad Lipi...mentioning

confidence: 99%

Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

Luo,

Yang,

Yao

2024

Mol Neurodegeneration

View full text Add to dashboard Cite

Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer’s disease. The role of gut microbiota in Alzheimer’s disease is diverse and complex, evidence suggests lipid metabolism may be one of the potential pathways. However, the mechanisms that gut microbiota mediate lipid metabolism in Alzheimer’s disease pathology remain unclear, necessitating further investigation for clarification. This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer’s disease based on existing data.

show abstract

Treadmill Exercise Modulates Intestinal Microbes and Suppresses LPS Displacement to Alleviate Neuroinflammation in the Brains of APP/PS1 Mice

Cited by 33 publications

References 85 publications

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Moderate-intensity continuous training and high-intensity interval training modulate gut microbes, and weaken leaky gut-immune activation reduces systemic inflammation in high-fat diet APOE-KO mice

Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

Contact Info

Product

Resources

About