Trazodone and imipramine: Comparative effects on canine cardiac conduction

Gomoll, Allen W.; Byrne, Jeffrey E.

doi:10.1016/0014-2999(79)90496-5

Cited by 31 publications

(5 citation statements)

References 12 publications

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“…Results of other studies [23][24][25] indicate trazodone is cardiodepressive in dogs; however, this finding is for anesthetized dogs, which may complicate interpretation of the results. Results of another study 23 indicate anesthetized dogs have a significant and dose-dependent decrease in mean arterial blood pressure and heart rate after IV administration of trazodone.…”

Section: Discussionmentioning

confidence: 70%

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

Jay¹,

Krotscheck²,

Parsley³

et al. 2013

ajvr

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Results of this study indicated oral administration of trazodone resulted in acceptable absolute bioavailability, with substantial variability in time to maximum plasma concentration. Individualized approaches in dosing intervals may be necessary for dogs receiving oral trazodone. An orally administered dose of 8 mg/kg was well tolerated in dogs; IV administration of a dose of 8 mg/kg caused substantial adverse effects, including tachycardia and behavior disinhibition.

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Section: Discussionmentioning

confidence: 70%

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

Jay¹,

Krotscheck²,

Parsley³

et al. 2013

ajvr

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“…In every respect, except one, trazodone lived up to the benign cardiovascular profile predicted by the animal and human studies of Gomoll [21,22], Gomoll and Byrne [23] and La Rochelle et al [24] reviewed by llimmelhoch [25] in 1981. The problem still in question is the observation of Janowskyex al.…”

Section: Cardiovascular Effects O F Trazodonementioning

confidence: 99%

The Role of Trazodone in the Treatment of Depressed Cardiac Patients

Himmelhoch¹,

Schechtman²,

Auchenbach³

1984

Psychopathology

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The novel antidepressant trazodone is hypothesized to be less cardiotoxic than the tri-tetracyclic antidepressants. Recently, however, 2 patients with preexisting ventricular irritability showed an increased number of ventricular premature beats and of repetitive forms after starting on trazodone. Data are presented here from four studies on the cardiovascular safety of trazodone. Conclusions are: (1) Trazodone has little effect on cardiac conduction. (2) Trazodone does not worsen supraventricular arrhythmias. (3) Trazodone produces less postural hypotension than most other antidepressants and it tends to lower heart rate. (4) Lower doses of trazodone (100–300 mg) are better tolerated and more effective in major depressives simultaneously debilitated by significant cardiovascular disease. (5) It is possible that the so-called ‘trazodone aggravation’ of ventricular irritability is a statistical artifact – although further research is needed to verify this conclusion, and in the meantime the drug should be used with caution in such patients.

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“…The tricyclic antidepressants are still regarded by many practitioners as the standard pharmacological approach to the treatment of depression. This continues to be so in spite of the advent of newer and less toxic antidepressants such as mianserin and maprotiline (Hughes & Radman, 1978) and *trazodone (Gomoll & Byrne, 1979). Despite being available for over 20 years the efficacy of the tricyclic antidepressants has not been superseded by the newer compounds.…”

Section: Discussionmentioning

confidence: 99%

A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers.

Robinson¹,

Doogan²

1982

Brit J Clinical Pharma

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1 Fluvoxamine and clovoxamine, two new potential antidepressants were given to 27 healthy male volunteers in a double‐blind, placebo controlled, three‐way crossover study. 2 Neither compound affected the electrical intervals of 24 h ambulant electrocardiographic monitoring with the exception of a small increase in R‐R interval. 3 There were no changes in blood pressure measurements. 4 The only notable unwanted symptom was nausea for both fluvoxamine and clovoxamine.

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Trazodone and imipramine: Comparative effects on canine cardiac conduction

Cited by 31 publications

References 12 publications

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

The Role of Trazodone in the Treatment of Depressed Cardiac Patients

A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers.

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