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Background and Purpose: We tested the hypothesis that inhibition of leukocyte function by administration of monoclonal antibody 60.3 (MoAb 60.3) improves electrophysiological recovery and decreases injury volume following transient focal cerebral ischemia in cats.Methods: Halothane-anesthetized cats underwent 90 minutes of left middle cerebral artery and bilateral common carotid artery occlusion followed by 180 minutes of reperfusion. Cats were assigned to receive either 2 mg/kg MoAb 60.3 (n=8) directed at the CDwl8 leukocyte antigen complex or an equal volume of diluent (sterile saline; n=10) at 45 minutes of ischemia in a blinded fashion.Results: Blood flow to the left temporoparietal cortex decreased to <5 ml/min/100 g with ischemia, but was minimally affected on the right side.

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