Traumatic Ulcerative Granuloma With Stromal Eosinophilia: A Lesion With Alarming Histopathologic Presentation and Benign Clinical Course

Gagari, Eleni; Stathopoulos, Panagiotis; Katsambas, Andreas; Avgerinou, Georgia

doi:10.1097/dad.0b013e3181e26db0

Cited by 28 publications

(24 citation statements)

References 20 publications

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“…It appears as a red lesion in oral mucosa with rolled, elevated and indurated margins with central areas of fibrinopurulent membrane mimicking squamous cell carcinoma. [ 25 26 27 ] Even though, tongue[ 28 29 30 ] is the most common site, other regions like buccal mucosa, vestibular mucosa, gingiva, lip,[ 31 ] mucobuccal fold, retromolar area, and palate[ 32 ] also may exhibit TUGSE. Histopathologically, TUGSE exhibits ulceration with diffuse polymorphic inflammatory infiltrate (exhibiting epitheliotropism) extending from the superficial epithelium into the deep connective tissue.…”

Section: Discussionmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

et al. 2015

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Oral ulcers are a common symptom in clinical practice. Among various causative factors, different types of ulcers in oral cavity exist. Among this, traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) appears to be quite neglected by the clinicians due to the limited knowledge and awareness. On reviewing with a detailed approach to titles and abstracts of articles eliminating duplicates, 40 relevant articles were considered. Randomized studies, review articles, case reports and abstracts were included while conference papers and posters were excluded. Of importance, TUGSE cases been reported only to a minimal extent in the literature. Lack of its awareness tends to lead clinicians to a misconception of cancer. Thus, this particular lesion needs to be differentiated from other malignant lesions to provide a proper mode of treatment. The present article reviews various aspects of the TUGSE with emphasis on the clinical manifestation, pathogenesis, histological, and immunohistochemical study. This study provides the clinician contemporaries, a humble expansion to their knowledge of the disease, based on the searched literature, enabling a more comprehensive management of this rare occurrence.

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Section: Discussionmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

et al. 2015

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“…On this point, Eleni et al consider that such behavior may be indicative of a healing response reactivation after the surgical intervention, but the reason for this improvement is to date unknown. 10 …”

Section: Discussionmentioning

confidence: 99%

“…Although EUOM is a benign affection, monitoring is mandatory in all cases, as low-grade lymphoma may show a very similar clinical presentation in oral mucosa. 10 …”

Section: Discussionmentioning

confidence: 99%

Eosinophilic ulcer of the tongue - Case report

Didona

Paolino

Donati

et al. 2015

An. Bras. Dermatol.

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Eosinophilic ulcer of the oral mucosa is a rare, self-limiting, chronic and benign lesion of unknown pathogenesis that affects the oral mucosa. We present the case of a 65 year-old Caucasian female with a fivemonth history of a painful ulcer on the lateral side of her tongue. The ulcer was not adhered to the underlying structures and there was no evidence of regional lymph node involvement. Laboratory examinations and X-rays revealed no abnormalities. Topical treatments had been performed without any improvement. Histopathological examination showed an ulcerated surface and mixed inflammatory infiltrate with several eosinophils extending into the mucosa and submucosa. No cellular atypia was observed. Based on the patient-s history and mucosal biopsy, a final diagnosis of eosinophilic ulcer of the oral mucosa was made.

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“…Eosinophilic ulcer also has been referred as traumatic ulcerative granuloma with stromal eosinophilia, traumatic eosinophilic granuloma, traumatic granuloma, and ulcerative eosinophilic granuloma. [ 4 5 6 7 ] In infants, usually on the ventral surface of the anterior tongue secondary to trauma from newly erupted primary teeth, the eosinophilic ulcer is referred as Riga–Fede disease. [ 8 9 10 ]…”

Section: Introductionmentioning

confidence: 99%

Oral eosinophilic or traumatic ulcer: A case report and brief review

Dhanrajani

Cropley²

2015

Natl J Maxillofac Surg

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Eosinophilic ulcer of the oral mucosa is considered to be a benign, reactive, and self-limiting lesion, with unclear pathogenesis, manifesting as a rapidly developing solitary ulcer. We report a case of a 42-year-old man who presented with a chronic indurated ulcer of buccal mucosa adjacent to the right upper wisdom tooth. Histopathological examination showed polymorphic inflammatory infiltrate, rich in eosinophilis, involving the superficial mucosa, and the deeper muscle layer. Immunohistochemical analysis revealed single CD30+ cells scattered within an inflammatory infiltrate. The lesion was excised, and healing was uneventful with no recurrence in more than a year.

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Traumatic Ulcerative Granuloma With Stromal Eosinophilia: A Lesion With Alarming Histopathologic Presentation and Benign Clinical Course

Cited by 28 publications

References 20 publications

Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited

Eosinophilic ulcer of the tongue - Case report

Oral eosinophilic or traumatic ulcer: A case report and brief review

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