Eosinophilic ulcer of the tongue - Case report

Abstract

Eosinophilic ulcer of the oral mucosa is a rare, self-limiting, chronic and benign lesion of unknown pathogenesis that affects the oral mucosa. We present the case of a 65 year-old Caucasian female with a fivemonth history of a painful ulcer on the lateral side of her tongue. The ulcer was not adhered to the underlying structures and there was no evidence of regional lymph node involvement. Laboratory examinations and X-rays revealed no abnormalities. Topical treatments had been performed without any improvement. Histopathological examination showed an ulcerated surface and mixed inflammatory infiltrate with several eosinophils extending into the mucosa and submucosa. No cellular atypia was observed. Based on the patient-s history and mucosal biopsy, a final diagnosis of eosinophilic ulcer of the oral mucosa was made.

Eosinophilic Ulcer of the Tongue in a Patient with Cerebral Palsy: A Case Report

“…There are numerous therapeutic approaches toward eosinophilic ulceration of oral mucosa, including eliminating the etiologic factors such as trauma, excision and curettage, medications such as corticosteroids and antibiotics, and cryosurgery (11). Our case healed after the extraction of sharpened and broken teeth; therefore, no surgical excision was required.…”

“…It has been proposed that traumas prompt the characteristics of inflammatory reactions by entering the infections and external proteins in the individuals who are susceptible. There is another theory that it represents a CD30+ lymphoproliferative disorder (10,11).…”

“…The lesion may be characterized by a superficial fibrinous membrane and a white or yellowish base with peripheral erythema. Although it can affect any mucosal surfaces, the tongue is the most common site, especially the lateral and dorsal sides (5,11).…”

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“…sharp teeth). Spontaneous healing frequently occurs within 30 days, even if cases of 8-month standing lesions have been reported [16].…”

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“…In January 2015, the lesion had increased in size, and an excisional biopsy was performed. The initial diagnostic hypothesis was a drug-induced side effect initiated by the Alendronate treatment ( 19 , 20 ) for osteoporosis, which caused an eosinophilic ulcer ( 21 , 22 ). A computed tomography (CT) scan did not show any lesions of the mandible or signs indicative of bisphosphonate-related osteonecrosis of the jaw.…”