Abstract:BackgroundTraumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare self-limiting condition of the oral mucosa. The lesion manifests as an isolated ulcer that can be either asymptomatic or associated with mild to severe pain, and in most cases, it affects the tongue. TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30 positive lymphoproliferative disorder, or infectious diseases such as primary syphilis, tuberculosis, or Epstein-Barr virus mucocutaneous ulcer. Histological… Show more
“…TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30-positive lymphoproliferative disorder or infectious diseases such as primary syphilis, tuberculosis or Epstein–Barr virus mucocutaneous ulcer. [ 3 ]…”
“…TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30-positive lymphoproliferative disorder or infectious diseases such as primary syphilis, tuberculosis or Epstein–Barr virus mucocutaneous ulcer. [ 3 ]…”
“…Benign ulcerations of the oral mucosa may have a similar appearance to malignant lesions [1,2]. There are several conditions, both local and systemic, that can manifest as oral ulcers, and that can correspond, on many occasions, to both infectious and autoimmune causes.…”
Section: Introductionmentioning
confidence: 99%
“…Other less common locations are the palatal and gingival mucosa and the floor of the mouth [3]. The diagnosis of Eosinophilic Ulcer is difficult and requires a correct differential diagnosis, since different entities may share both the clinical and histopathological results [2].…”
“…3 It often presents as a solitary asymptomatic or painful ulcer and may last from weeks to months. 4 It is most commonly diagnosed in the 5th decade of life, but can present at any age and is referred to as Riga-Fede disease if diagnosed in neonates or infants. 5,6 The major etiology for TUGSE is trauma; however, some of the other possible causes include sharp tooth margins, ill-fitted dentures, and incisional biopsies.…”
Section: Introductionmentioning
confidence: 99%
“…It often presents as a solitary asymptomatic or painful ulcer and may last from weeks to months 4 . It is most commonly diagnosed in the 5th decade of life, but can present at any age and is referred to as Riga‐Fede disease if diagnosed in neonates or infants 5,6 .…”
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