Traumatic Fat Necrosis: A Case Report

Tillman, Cecilia; Holst, R; Svedman, Cecilia

doi:10.1080/00015550310007292

Cited by 9 publications

(12 citation statements)

References 9 publications

(9 reference statements)

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“…This difference was attributable to having a better blood flow of the free TRAM flaps [ 20 ]. Rare partial and absent complete flap necrosis in the Erdmann's series was attributable to the delay in unipedicled flaps [ 21 ]. The epigastric adipocutaneous flap model was used for the second part of the experiment.…”

Section: Discussionmentioning

confidence: 99%

Ischemia‐Reperfusion Injury of Adipofascial Tissue: An Experimental Study Evaluating Early Histologic and Biochemical Alterations in Rats

Çoban

Kurutaş

Çıralık

2005

Mediators of Inflammation

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Fat necrosis remains a serious complication in reconstructive flaps. In clinical setting, it is well known that fat tissue is more susceptible to ischemic events. We aimed to evaluate early histological and biochemical changes of adipofascial tissue in an experimantal model. An epigastric flap model in rats was used to evaluate the effect of ischemia-reperfusion (I-R) injury on adipofascial tissue. Two groups of animals (one with ischemia alone and other ischemia-reperfusion group) were used to evaluate the degree of histological edema, congestion and extravascular bleeding, and early biochemical alterations within the adipofascial flaps. The biochemical parameters included glutathione (GSH) and malondialdehyde (MDA). In each group, contralateral groin subcutaneous adipose tissue served as control. These evaluations were compared to normal unmanipulated, contralateral abdominal subcutaneous adipose tissue. The ischemia-reperfused flap group showed histologically significantly much edema congestion and bleeding than the control groups (P < .0001). The control group showed less edema in fat tissue than the ischemia-alone group (P < .05). All of the flaps in the ischemia-only group showed significantly less bleeding and edema than I-R group (P < .001). The ratio of MDA/GSH was 33 in control, 37 in ischemia alone, and 82 in ischemia-reperfusion groups, respectively. This study confirms that significant histologic and biochemical alteration occurs after ischemia and ischemia-reperfusion events in adipose tissue. Marked drop in adipose tissue antioxidant levels after I-R suggested that preemptive measures to this decrease should be undertaken in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Ischemia‐Reperfusion Injury of Adipofascial Tissue: An Experimental Study Evaluating Early Histologic and Biochemical Alterations in Rats

Çoban

Kurutaş

Çıralık

2005

Mediators of Inflammation

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“…Numerous diseases have been reported in association with FN: pancreatitis, collagen vascular diseases, myeloproliferative disorders, asphyxia, hypothermia, subcutaneous injections, and trauma. 3,4 In fact, the fat is composed of microlobules of fat cells; each microlobule is serviced by a blood vessel. In situations where there is pressure on the fat compartments, they burst and the surrounding septa and vessels rupture, leading to the damage of the fat cells.…”

Section: Discussionmentioning

confidence: 99%

Fat necrosis: A neglected side effect of intramuscular injections

Kouki

Amouri

Bahloul

et al. 2022

Clinical Case Reports

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Panniculitis has various etiologies. One of the less common causes is trauma and hence traumatic fat necrosis (FN). These soft tissue injuries usually appear on the shins, thighs, breasts, arms, and buttocks. FN is mainly caused by trauma and may be associated with other conditions such as pancreatic disease. FN arising after intramuscular injections is uncommon and usually appears as firm, encapsulated, mobile, nontender, and solitary or multiple subcutaneous nodules.We report an interesting case of FN caused by intramuscular injections of cefazolin and meglumine antimoniate (MA) in a 38-year-old female patient. MA is regarded as the first-line systemic treatment for cutaneous leishmaniasis (CL).However, these drugs are not devoid of various potentially adverse reactions.

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“…Subcutaneous fat necrosis in children account for 13% of referrals for an MRI of softtissue mass [4]. In one case of posttraumatic subcutaneous fat necrosis appearing as a lump, the redness and ulceration appeared after frequent rubbing of the area and traumatizing the lesion [2]. Often the interval between the trauma and the initial observation of the lesion is prolonged [4], and a history of trauma may not be obtained, adding to the perplexing diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…It is more prevalent in women and usually appears on the shins, thighs, arms, breasts, and buttocks [2]. In children the most common site is the cheek following injury to the face.…”

Section: Introductionmentioning

confidence: 99%

Posttraumatic Fat Necrosis Presented as Cellulitis of the Leg

Herzberger

Aviner

Cherniavsky

2012

Case Reports in Pediatrics

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Cellulitis, a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin, is a common lesion in children, usually responsive to systemic antibiotic therapy. However, an unusual course of healing or some nontypical features should call the treating physician to consider and investigate for other diagnoses that might prevent unnecessary treatment and alleviate parental stress. We present a case of posttraumatic fat necrosis, demonstrating some pitfalls in the process of diagnosis.

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Traumatic Fat Necrosis: A Case Report

Cited by 9 publications

References 9 publications

Ischemia‐Reperfusion Injury of Adipofascial Tissue: An Experimental Study Evaluating Early Histologic and Biochemical Alterations in Rats

Ischemia‐Reperfusion Injury of Adipofascial Tissue: An Experimental Study Evaluating Early Histologic and Biochemical Alterations in Rats

Fat necrosis: A neglected side effect of intramuscular injections

Posttraumatic Fat Necrosis Presented as Cellulitis of the Leg

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