Traumatic facial nerve neuroma following mastoid surgery: a case report and literature review

Rainsbury, James; Whiteside, Olivia; Bottrill, Ian

doi:10.1017/s0022215106004993

Cited by 15 publications

(12 citation statements)

References 6 publications

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“…Histologically, traumatic neuroma can be characterized as non-encapsulated, non-neoplastic conglomerates of cells and axons embedded in a dense fibrotic matrix [ 16 , 17 ]. Some studies and case reports have described traumatic neuroma presenting tangled morphology, composed of connective tissue, Schwann cells, and regenerating axons [ 17 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Time course of traumatic neuroma development

et al. 2018

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This study was designed to characterize morphologic stages during neuroma development post amputation with an eye toward developing better treatment strategies that intervene before neuromas are fully formed. Right forelimbs of 30 Sprague Dawley rats were amputated and limb stumps were collected at 3, 7, 28, 60 and 90 Days Post Amputation (DPA). Morphology of newly formed nerves and neuromas were assessed via general histology and neurofilament protein antibody staining. Analysis revealed six morphological characteristics during nerve and neuroma development; 1) normal nerve, 2) degenerating axons, 3) axonal sprouts, 4) unorganized bundles of axons, 5) unorganized axon growth into muscles, and 6) unorganized axon growth into fibrotic tissue (neuroma). At early stages (3 & 7 DPA) after amputation, normal nerves could be identified throughout the limb stump and small areas of axonal sprouts were present near the site of injury. Signs of degenerating axons were evident from 7 to 90 DPA. From day 28 on, variability of nerve characteristics with signs of unorganized axon growth into muscle and fibrotic tissue and neuroma formation became visible in multiple areas of stump tissue. These pathological features became more evident on days 60 and 90. At 90 DPA frank neuroma formation was present in all stump tissue. By following nerve regrowth and neuroma formation after amputation we were able to identify 6 separate histological stages of nerve regrowth and neuroma development. Axonal regrowth was observed as early as 3 DPA and signs of unorganized axonal growth and neuroma formation were evident by 28 DPA. Based on these observations we speculate that neuroma treatment and or prevention strategies might be more successful if targeted at the initial stages of development and not after 28 DPA.

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Section: Introductionmentioning

confidence: 99%

Time course of traumatic neuroma development

et al. 2018

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“…Gerçek bir neoplazi değildir. Sinir hasarına bağlı hiperplastik bir yanıttır ve ele gelen ağrılı kitle şeklinde semptom verir (16). Kapsüllü değillerdir.…”

Section: Discussionunclassified

Schwannoma of breast: a case report

Baş¹,

Demirci²,

Özkan³

et al. 2018

JCurrPath

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Tel: 0 541 911 81 12 (J Curr Pathol. 2018;1:16-20.) ÖZET Amaç: Schwannoma myelin üreten Schwan hücrelerinden köken alan benign, kapsüllü, periferik sinir kılıfı tümörüdür. Schwannoma meme dokusunda çok nadir görülür ve izlenen çoğu olguda meme derisi ve subkutanöz yerleşimlidir. Biz burada son derece nadir lokalizasyonda izlenen bu tümöral lezyonu yaratacağı ayrıcı tanı karmaşasını da göz önüne alarak sunduk.Olgu: 26 yaşında kadın hasta sol memede 14 yıldır mevcut olan ve zaman zaman ağrı yapan kitle nedeniyle lumpektomi operasyonu geçirmiş ve Schwannoma tanısı almıştır. Sonuç:Meme yerleşimli Schwannoma oldukça nadir görülen ve memedeki diğer iğsi hücreli neoplazilerle ayrıcı tanı karmaşası yaratan bir lezyondur.Anahtar Sözcükler: Schwannoma, Meme, İğsi hücreli lezyonlar ABSTRACT Aim: Schwannoma is a benign, encapsulated, biphasic peripheral nerve sheath tumor originating in Schwan cells producing myelin. Schwannoma is very rare in the breast, and most cases are present in breast skin and subcutaneous tissue. Here we present Schwannoma of breast and discuss the differential diagnosis. Case:A 26-year-old woman had lumpectomy due to a painful mass that had been present in her left breast for 14 years and was diagnosed with Schwannoma. Conclusion:Schwannoma of breast is a rare lesion that needs to be distinguished from other spindle-cell neoplasms.

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“…It represents a hyperplastic reponse of the nerve to injury, either direct/indirect trauma or chronic inflammation. Traumatic neuromas show disrupted axons with distal demyelination and Wallerian degeneration, and a tangled mass of Schwannou cells and fibroblasts, all in a dense, collagenous matrix [3]. Enzinger FM et al [9] and Murphey M at el [10] consider that a traumatic neuroma usually presents as a palpable nodule which is caused by a non-neoplastic proliferation of the proximal end of a severed, partially transected or injoured nerve after surgery and it dosen't have any potential malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…It represents a hyperplastic, reparative response of the nerve to injury and usually presents as a palpable nodule mass. It is secondary to the disordered proliferation of nerves and connective tissue trying to renervate the area after a total or partial sectioning of anerve during an accidental or surgical trauma [3]. Traumatic neuromas occurring near the mastectomy scar are more rare.…”

Section: Introductionmentioning

confidence: 99%

Traumatic neuroma in a patient with breast cancer after mastectomy: a case report and review of the literature

Gao

Yang

et al. 2012

World J Surg Onc

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The incidence of traumatic neuroma is extremely low, especially in those patients with breast cancer after mastectomy. There are only 10 cases reported in the literature. We report a patient who developed a palpable nodular mass near the mastectomy scar. The result of excisional biopsy was traumatic neuroma. Review of the literature reveal 10 cases with breast cancer of traumatic neuromas after mastectomy. Traumatic neuroma is a benign lesion and a reparative response of the nerve to injury, either direct/indirect trauma or chronic inflammation. Benign lesions as traumatic neuromas are more rarely seen after mastectomy. However, in order to manage patients' treatment, the most critical problem is to distinguish it from recurrent breast carcinoma. Although assistant examination methods such as ultrasound and computed tomography are valuable to a certain extent, the final diagnosis can only be confirmed on pathologic examination.

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Traumatic facial nerve neuroma following mastoid surgery: a case report and literature review

Cited by 15 publications

References 6 publications

Time course of traumatic neuroma development

Time course of traumatic neuroma development

Schwannoma of breast: a case report

Traumatic neuroma in a patient with breast cancer after mastectomy: a case report and review of the literature

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