Traumatic Brain Injury Has Not Prominent Effects on Cardiopulmonary Indices of Rat after 24 Hours: Hemodynamic, Histopathology, and Biochemical Evidence

Najafipour, Hamid; Khachaki, Ali Siahposht; Khaksari, Mohammad; Shahouzehi, Beydolah; Joukar, Siyavash; Poursalehi, Hamid Reza

doi:10.6091/ibj.13222.2014

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Chen et al showed elevation of IL-1 β level at 1 and 6 hours, as well as on days 1 to 5 after TBI in intestinal tissue of rat, but they reported no change in levels of IL-6 [ 47 ]. Najafipour et al did not observe change in level of these two inflammatory factors of heart rat 24 hours following TBI which may be due to differences in trauma severity and timing of post-Traumatic inflammatory factor evaluation [ 42 ]. This study showed a reduction in amount of IL-10 of the heart and the kidney after TBI.…”

Section: Discussionmentioning

confidence: 99%

“…One study showed that following TBI, histopathological changes such as edema, inflammation, and apoptosis appeared in other tissues, including the liver [ 54 ]. However, in the study of Najafipour et al after TBI, no changes in histopathological outcome were observed 24 hours after injury which is probably due to the severity of trauma and the time of assessment of post-Traumatic histopathological outcome [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Histopathological findings of the heart were in terms of necrosis, myofibrillar degeneration, vascular congestion, hemorrhage, leukocyte infiltration, and interstitial edema were scored as follows [ 40 – 42 ]:…”

Section: Methodsmentioning

confidence: 99%

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The Prescription of Oral Mucosal Mesenchymal Stem Cells post-Traumatic Brain Injury Improved the Kidney and Heart Inflammation and Oxidative Stress

Radavi-Asgar

Sabet

Khaksari

et al. 2022

BioMed Research International

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Background. In the last years, mesenchymal stem cells (MSCs) have been considered as a useful strategy to treat many diseases such as traumatic brain injury (TBI). The production of inflammatory agents by TBI elicits an inflammatory response directed to other systems of body, such as the heart and the kidneys. In this study, the efficacy of oral mucosal mesenchymal stem cells (OMSCs) prescription after TBI in inflammation and oxidative stress of the heart and kidneys was evaluated. Methods. Twenty-four male rats were located in groups as follows: sham, TBI, vehicle (Veh), and stem cell (SC). OMSCs were injected intravenously 1 and 24 hours after TBI. Inflammatory, oxidative stress, and histopathological outcomes of the heart and kidney tissues were investigated 48 hours after TBI. Results. TBI caused an increase in the level of interleukin-1β (IL-1β), interleukin-6 (IL-6), malondialdehyde (MDA), and carbonyl protein (PC) of the heart and kidney compared to the sham group. Superoxide dismutase (SOD), total antioxidant capacity (TAC), catalase (CAT), and interleukin-10 (IL-10) of the heart and kidney decreased after TBI. The use of OMSCs after TBI reduced the changes of these factors in both the heart and the kidney. Conclusion. Application of OMSCs after TBI can decrease inflammation and oxidative stress of the heart and kidney tissues leading to the reduction of damage. Therefore, this method can be evaluated in the TBI patients in future studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Prescription of Oral Mucosal Mesenchymal Stem Cells post-Traumatic Brain Injury Improved the Kidney and Heart Inflammation and Oxidative Stress

Radavi-Asgar

Sabet

Khaksari

et al. 2022

BioMed Research International

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The anti-inflammatory properties of Satureja khuzistanica Jamzad essential oil attenuate the effects of traumatic brain injuries in rats

Abbasloo¹,

Dehghan²,

Khaksari³

et al. 2016

Sci Rep

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Traumatic brain injury (TBI) is a major health concern affecting the general public as well as military personnel. However, there is no FDA-approved therapy for the treatment of TBIs. In this work, we investigated the neurotherapeutic effects of the well-known natural Iranian medicine Satureja Khuzistanica Jamzad (SKJ) essential oil (SKEO) on the outcomes of diffused experimental TBI, with particular attention paid to its anti-inflammatory and anti-apoptotic effects. Male Wistar rats were treated with doses of 50, 100 and 200 (mg/kg, i.p) SKEO after induction of diffused TBIs. The results showed that injecting SKEO (200 mg/kg) 30 minutes after TBI significantly reduced brain oedema and damage to the blood-brain barrier (BBB) and limited the post-TBI increase in intracranial pressure. The veterinary coma scale (VCS) scores significantly improved in the treatment group. Also, inflammatory marker assays showed reduced levels of TNF-α, IL-1β, and IL-6 and increased IL-10 in the treated groups. Moreover, the immunohistochemical results indicated that SKEO not only reduced neuronal death and BBB permeability but also affected astrocytic activation. Overall, our data indicate potential clinical neurological applications for SKEO.

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Traumatic brain injury is not associated with significant myocardial dysfunction: an observational pilot study

Serri

Rayes

Giraldeau

et al. 2016

Scand J Trauma Resusc Emerg Med

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BackgroundMyocardial dysfunction has been well described with catastrophic neurological events, such as subarachnoid hemorrhage and brain death. There is very limited data describing myocardial function in the context of traumatic brain injury (TBI), as no prospective study has yet examined this association. The objective of our study was to evaluate cardiac function using echocardiography in patients with clinically important TBI.MethodsWe conducted a prospective observational study of consecutive TBI patients admitted to the intensive care unit. All patients older than 16 years with moderate to severe TBI according to the Glascow Coma Scale (GCS) were eligible for the study. Only patients with a prior history of heart disease or cardiomyopathy or evidence of brain death on admission were excluded. A complete transthoracic echocardiogram was performed within 4 days of admission.ResultsForty-nine patients (67 % males, median age 34 years) were included in the study. Forty-one patients had severe TBI (84 %) with a median GCS of six, 44 patients (90 %) required mechanical ventilation and 36 (74 %) intracranial pressure monitoring. Hospital mortality was 18 %. No patients had global left ventricular dysfunction as defined by a left ventricular ejection fraction (LVEF) below 50 % (95 % CI, 0–0.07). Average LVEF was 65 +/− 4 %. Four patients (8 %) had regional wall motion abnormalities with preserved LVEF.DiscussionThe main finding of this study is the absence of clinically significant myocardial dysfunction in patients with moderate or severe TBI. Although myocardial dysfunction has been well described in a variety of neurological settings, it is possible that the young age of TBI patients and the absence of cardiovascular risk factors are protective against significant myocardial injury from catecholamine excess.ConclusionsIn a group of patients with clinically important TBI, we did not identify any significant cardiac dysfunction.

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Traumatic Brain Injury Has Not Prominent Effects on Cardiopulmonary Indices of Rat after 24 Hours: Hemodynamic, Histopathology, and Biochemical Evidence

Cited by 6 publications

References 26 publications

The Prescription of Oral Mucosal Mesenchymal Stem Cells post-Traumatic Brain Injury Improved the Kidney and Heart Inflammation and Oxidative Stress

The Prescription of Oral Mucosal Mesenchymal Stem Cells post-Traumatic Brain Injury Improved the Kidney and Heart Inflammation and Oxidative Stress

The anti-inflammatory properties of Satureja khuzistanica Jamzad essential oil attenuate the effects of traumatic brain injuries in rats

Traumatic brain injury is not associated with significant myocardial dysfunction: an observational pilot study

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