Traumatic Brain Injury and Behavior

McGee, Jeanie; Alekseeva, Nadejda; Chernyshev, Oleg; Minagar, Alireza

doi:10.1016/j.ncl.2015.08.004

Cited by 10 publications

(8 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are few studies that explore the connection between TBI and psychosis; however, post-TBI psychosis has an incidence 2-3 times greater than the general population. 4 , 11 The onset of TBI-associated psychosis may be acute or delayed, and when there are comorbid seizures, may occur in the peri-ictal period or interictally. 2 , 11 In this case, the patient appeared to have interictal psychosis as the symptoms were chronic in nature versus episodic.…”

Section: Discussionmentioning

confidence: 99%

“…There are an estimated 1.4 million cases of TBI annually in the United States, and approximately 10% of these patients will develop TBI-associated psychosis. 2 - 4 Psychotic symptoms following TBI often present as hallucinations, delusions, and disorganized thought content. 3 There are currently no medications that are Food and Drug Administration (FDA)–approved for post-TBI psychosis, and there is a paucity of evidence on the pharmacologic treatment approach in this population.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A case report of guardian-consent forced paliperidone palmitate for behavioral disturbance due to traumatic brain injury

Douglass

Smyth²

2018

Mental Health Clinician

View full text Add to dashboard Cite

Psychosis after traumatic brain injury (TBI) occurs in up to 10% of cases. Although guideline consensus is lacking regarding drugs of choice for this condition, current literature points to the use of atypical antipsychotics. This case describes a 58-year-old male with major neurocognitive disorder due to TBI with behavioral disturbance that was successfully treated with paliperidone palmitate. In addition to the off-label use of paliperidone, this case also explores the use of forced medication as the initial injection was given per guardian consent. After completion of a literature review, this appears to be the first case report describing the use of a long-acting antipsychotic for the treatment of TBI-related psychosis. This case suggests that paliperidone palmitate may be efficacious for psychosis following TBI; however, further study is warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A case report of guardian-consent forced paliperidone palmitate for behavioral disturbance due to traumatic brain injury

Douglass

Smyth²

2018

Mental Health Clinician

View full text Add to dashboard Cite

show abstract

“…In addition, symptoms associated with an early age of onset, such as loss of consciousness or apnoea, can greatly harm brain development and, thus, affect patient prognosis. 37 An early age of onset may also play an important role in widely distributed dysplasia, 38 which is already known to cause poor mental outcomes. The odds ratio (early onset age versus late onset age in predicting negative seizure outcome) was up to 2.65, and early age onset should be treated as a strong predictor for poor seizure control.…”

Section: Discussionmentioning

confidence: 99%

Five-Year Long-Term Prognosis of Epileptic Children After Hemispheric Surgery

et al. 2016

View full text Add to dashboard Cite

To estimate children's long-term seizure outcomes after hemispheric surgery and the associated predictors.A systematic review of 4 databases and a meta-analysis were performed from January 1, 1995 to August 31, 2015. The databases included PubMed, Embase, Science Direct, and Web of Science; patients were classified into the Engel Class I group and the Engel Class II to IV group, according to their seizure outcomes. Nine potential predictors were then stratified across the groups and estimated using the Wilcoxon rank-sum test for continuous variables and the Chi-squared test for categorical variables.The search yielded 15 retrospective studies, with a total sample size of 380. Five years after surgery, 268 (0.71, 95% confidence interval [CI]: 0.64–0.78) children were seizure free; the seizure onset age in the Engel Class I group was significantly higher than that of the Engel Class II to IV group (standardized mean difference [SMD] = 0.26, 95% CI: 0.03–0.49, P = 0.028); specifically, when predicting the positive long-term outcomes, the odds ratio for late onset age (≥3.6 months, median value of the Engel Class II–IV group) versus early onset age was 2.65 (95% CI: 1.454–4.836, z = 3.18, P = 0.001). The abnormal magnetic resonance imaging (MRI) findings were more predictive for positive seizure outcomes than the normal findings (odds ratio [OR] = 4.60, 95% CI: 1.27–16.62, P = 0.02).Following hemispheric surgery, the long-term prognosis of children with epilepsy was good. Late seizure onset (age ≥ 3.6 months) and abnormal MRI findings were positive predictors for long-term seizure control in children.

show abstract

“…Linking these behavioral markers with specific injury attributes remains a persistent clinical challenge (McGee et al, 2016). Electroencephalographic recordings offer the potential to help to disassociate underlying causes of DOC by revealing systematic electrophysiological correlates of injury and behavior (Sitt et al, 2014; Sebastiano et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Coma and other disorders of consciousness (DOC) is associated with profound reductions in wakefulness and awareness (Bruno et al, 2011; Giacino et al, 2014; Laureys, 2005). Linking these behavioral markers with specific injury attributes remains a persistent clinical challenge (McGee et al, 2016). Electroencephalographic recordings offer the potential to help to disassociate underlying causes of DOC by revealing systematic electrophysiological correlates of injury and behavior (Sitt et al, 2014; Sebastiano et al, 2015).…”

Section: Introductionmentioning

confidence: 99%