Traumatic asphyxia successfully treated with jidabokuippo

Nakae, Hajime; Irie, Yasuhito; Satoh, Kasumi; Kitamura, Toshiharu; Kameyama, Koumei; Furuya, Tomoki; Okuyama, Manabu

doi:10.1002/tkm2.1260

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…We have used JDI for various trauma such as rib fractures, fractures of extremities, abdominal wall hematoma, and traumatic asphyxia ( Nakae et al, 2012 ; Nakae et al, 2015a ; Nakae et al, 2016 ; Kitamura et al, 2022 ; Nakae et al, 2015b ; Nakae et al, 2020 .).…”

Section: Effectiveness Of Jidabokuippomentioning

confidence: 99%

Application of Traditional Japanese Drug Jidabokuippo in a Modern Society

et al. 2022

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Background: Jidabokuippo (JDI) (治打撲一方) has been used in Japan to alleviate contusion-induced swelling and pain since medieval times.Method: This review investigated the effects of JDI on various symptoms in patients with trauma or static blood[TM1]. The PubMed and Igaku Chuo Zasshi databases were searched until 24 December 2021. We summarize the benefits of applying JDI to inflammatory conditions, including bruises.Results: JDI has been used to resolve blood [TM1] stasis, regulate qi in trauma patients, and treat inflammatory swelling and pain caused by rheumatoid arthritis and cellulitis. As the adverse event rate associated with JDI is low (1.3%), JDI is considered a safe drug.Conclusion: JDI can be used to resolve blood[TM1] stasis in trauma patients without adverse events associated with nonsteroidal anti-inflammatory drugs.

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Section: Effectiveness Of Jidabokuippomentioning

confidence: 99%

Application of Traditional Japanese Drug Jidabokuippo in a Modern Society

et al. 2022

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“…JDI is composed of Nuphar rhizome, Quercus bark, Cnidium rhizome, cinnamon bark, clove floral bud, rhubarb rhizome, and Glycyrrhiza root. JDI has not only been used for bruises and sprains but also been used for various injuries such as rib and extremity fractures [3][4][5][6][7]. Nevertheless, the incidence of adverse events associated with JDI is still unclear [8].…”

Section: Introductionmentioning

confidence: 99%

Safety of jidabokuippo administration based on adverse event rate

Kitamura

Nakae

Irie

et al. 2022

Traditional & Kampo Medicine

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Aim The incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate. Methods Adverse events to JDI treatment were observed in 14 patients (adverse event group) while 1090 had none (non‐adverse event group). We compared age, sex, comorbidity, dose, dosing period, concomitant use of Kampo prescription, and concomitant use of analgesics between these two groups. Results The adverse event rate was 1.3%. The most common adverse event was diarrhea caused by rhubarb rhizome (0.6%). The adverse event rate of Glycyrrhiza‐induced pseudoaldosteronism was 0.3%. All symptoms improved on JDI withdrawal or taking JDI after meals. Median duration of JDI was significantly shorter in the adverse event group than in the non‐adverse event group (P = 0.0141). Conclusion The adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome and Glycyrrhiza root.

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“…Furthermore, blood TM1 disturbance is effective for the acute treatment of trauma. Hematoma is considered a form of static blood TM1 ; therefore, formulations that are useful for treating static blood TM1 , such as keishibukuryogan and jidabokuippo, can be used ( 9 – 11 ). Satoh and Nakae reported that the administration of daijokito (DJT), which is composed of Magnolia bark, immature orange, rhubarb rhizome, and anhydrous mirabilitum, caused defecation in critically ill patients and significantly increased the stool volume.…”

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confidence: 99%