“…4 NDI can be primary (familial) or secondary (acquired) in dogs; however, no cases of primary NDI have been reported in cats. 2,13 Secondary NDI is caused by renal or metabolic disorders that interrupt the normal interaction of AVP with its tubular receptors in the kidney, disrupt renal tubular function or result in loss of the hypertonic renal medullary interstitial gradient. 4 Several diseases, such as hyperadrenocorticism, 17 pyometra, 18 pyelonephritis, 4 hyperthyroidism 19 and hyperaldosteronism 20 can lead to secondary NDI in the cat.…”