Central diabetes insipidus following cardiopulmonary arrest in a dog

Bellis, Tara; Daly, Meredith L.; Davidson, Benjamin

doi:10.1111/vec.12398

Cited by 8 publications

(12 citation statements)

References 23 publications

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“…DDAVP has been successfully used in other reports involving PTCDI in dogs (Authement et al, 1989;Bellis et al, 2015;Croton et al, 2019;Foley et al, 2009). In these cases, response to DDAVP therapy was confirmed with a combination of increased USG, increased urine osmolality, decreased serum osmolality, and normalized serum Na.…”

Section: Discussionmentioning

confidence: 90%

“…Authement et al (1989) was the first to describe CDI secondary to TBI in a dog who sustained a skull fracture at the level of the pituitary gland after being hit by a car. While CDI is most often seen secondary to TBI in dogs and cats, it has also been seen following cardiopulmonary arrest in an 8-week-old Golden Retriever (Bellis et al, 2015;Campbell & Bredhauer, 2005;Foley et al, 2009). In human medicine, PTCDI is extensively studied and associated with significantly increased morbidity and mortality, especially when developing early after TBI (Capatina et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…To date and to the author's knowledge, there are only five case reports involving PTCDI and dogs: two reports describing CDI following TBI, one report describing CDI following cardiopulmonary arrest, one report describing CDI after transsphenoidal surgery in a dog with Cushing's disease, and one report describing the developing of hypothalamic-pituitary axis deficiency following TBI (Authement et al, 1989;Bellis et al, 2015;Croton et al, 2019;Foley et al, 2009;Teshima et al, 2011). Of these reported cases of CDI, only two describe PTCDI.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic findings and successful management of central diabetes insipidus following a self-inflicted penetrating brain injury in a dog

Lacqua¹,

Rozanski²,

Dry³

et al. 2021

Braz. J. Vet. Med.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic findings and successful management of central diabetes insipidus following a self-inflicted penetrating brain injury in a dog

Lacqua¹,

Rozanski²,

Dry³

et al. 2021

Braz. J. Vet. Med.

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“…A further case of CDI was reported in a male intact dog after cardiopulmonary arrest which occurred following a surgical procedure. This dog was treated with DDAVP which was successfully discontinued after two weeks of therapy [25].…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Transient Central Diabetes Insipidus following Traumatic Brain Injury in a Dog

Croton

Purcell

Schoep

et al. 2019

Case Reports in Veterinary Medicine

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An 11-year-old female spayed Maltese presented comatose, half an hour after vehicular trauma, and was treated for traumatic brain injury and pulmonary contusions. The dog developed severe hypernatremia within six hours of presentation, which responded poorly to the administration of five percent dextrose in water. As central diabetes insipidus was suspected, desmopressin was trialled and resolution of hypernatremia was achieved six days later. Transient trauma-induced central diabetes insipidus has been described previously in two dogs; in the first, serum sodium concentrations were evaluated three days after injury and the other developed hypernatremia seven days after injury. To the authors’ knowledge, this is the first report of rapid onset, transient, and trauma-induced central diabetes insipidus in a dog that encompasses the complete clinical progression of the syndrome from shortly after injury through to resolution.

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“… 7 , 8 Additionally, non-structural causes of CDI that have been reported in other species include genetic mutations and hypoxic damage. 9 , 10 Factors such as the location damaged and size of the area affected influence whether the resulting DI is transient or permanent and, if transient, the time frame, duration and severity of clinical signs. 1 Studies in humans and veterinary species report that pituitary lesions are much more common than previously thought.…”

Section: Introductionmentioning

confidence: 99%

Congenital pituitary cyst resulting in adipsic central diabetes insipidus and secondary hypernatremia in a cat

Evenhuis

Epstein

Della-Maggiore

et al. 2021

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 9-month-old intact female domestic mediumhair cat presented with a 5-month history of obtundation, lethargy, hypernatremia (181 mmol/l; reference interval [RI] 151–158 mmol/l), hyperchloremia (142 mmol/l; RI 117–126 mmol/l), azotemia (blood urea nitrogen 51 mg/dl; RI 18–33 mg/dl), creatinine 3.0 mg/dl (RI 1.1–2.2 mg/dl), hyperphosphatemia (8.3 mg/dl; RI 3.2–6.3 mg/dl) and total hypercalcemia (11.4 mg/dl; RI 9–10.9 mg/dl), with concurrent polyuria with adipsia. Neurologic evaluation revealed proprioceptive deficits, and this finding paired with a history of focal seizure-like activity despite improving sodium concentrations suggested a cerebrothalamic lesion. For this reason, and historical and biochemical findings consistent with adipsic diabetes insipidus (DI), MRI of the brain was performed, which revealed a lesion of the hypophyseal fossa consistent with a pituitary cyst. Given the patient’s age and the timeline of clinical signs, a congenital pituitary cyst was strongly suspected. The patient was managed initially with intravenous fluids to correct the hypernatremia, then managed for more than 4 years with topical ocular desmopressin acetate administration and free water administered through a feeding tube. This cat’s clinical diagnosis included a congenital pituitary cyst with subsequent central DI and primary adipsia. Relevance and novel information The clinical presentations of primary adipsia or central DI are both rare in cats. This is the first report to describe these conditions occurring in a cat owing to a congenital pituitary cyst and describes successful long-term management of this condition.

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Central diabetes insipidus following cardiopulmonary arrest in a dog

Abstract: CPA has been described as a cause of ischemic injury to the pituitary gland resulting in CDI in people. To the authors' knowledge, this is the first report of a dog developing transient partial CDI following CPA and successful resuscitation.

Cited by 8 publications

References 23 publications

Diagnostic findings and successful management of central diabetes insipidus following a self-inflicted penetrating brain injury in a dog

Diagnostic findings and successful management of central diabetes insipidus following a self-inflicted penetrating brain injury in a dog

Successful Treatment of Transient Central Diabetes Insipidus following Traumatic Brain Injury in a Dog

Congenital pituitary cyst resulting in adipsic central diabetes insipidus and secondary hypernatremia in a cat

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