Tratamiento de la leishmaniasis localizada mediante el antimoniato de meglumina intralesional y la terapia fotodinámica

Costin, Adelina; Bonito, Frederico; Alves, João; Barreiros, Hugo

doi:10.1016/j.ad.2020.02.004

Cited by 1 publication

(2 citation statements)

References 9 publications

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“…A total of 79 articles were obtained from the PubMed database search. Of these, six articles were selected, according to selection criteria, representing a total of three cases of CL [8,9,23] and three cases of ML [10][11][12]. Of these cases, five were matched with cases retrieved through the hospital searches.…”

Section: Resultsmentioning

confidence: 99%

“…However, since reporting of CL is not mandatory, information regarding cases of this clinical form is dispersed between databases of different hospitals and a few publications in national and international journals and master/doctoral theses. Most cases described after 2000 are locally acquired and likely caused by L. infantum (even though species identification was seldom reported [7,8]); few cases suggested imported disease by dermotropic species from the New World (including those from the L. Viannia subgenus [9]). ML cases caused by endemic L. infantum have also been described [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological and Clinical Aspects of Cutaneous and Mucosal Leishmaniases in Portugal: Retrospective Analysis of Cases Diagnosed in Public Hospitals and Reported in the Literature between 2010 and 2020

Rocha,

Conceição,

Gonçalves

et al. 2024

Microorganisms

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Leishmania infantum, a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Health System. Cases were screened through a search of diagnostic discharge codes or positive laboratory results for Leishmania infection. Simultaneously, a comprehensive literature search was performed. Descriptive statistics and hypothesis testing were performed using IBM® SPSS® Statistics. A total of 43 CL and 7 ML cases were identified, with a predominance of autochthonous cases (86%). In CL, immunosuppressed individuals constituted a significant proportion of patients (48%), and in this group, disseminated CL (22%) and simultaneous VL (54%) were common. In autochthonous cases, lesions, mostly papules/nodules (62%), were frequently observed on the head (48%). The approach to treatment was very heterogeneous. ML cases were all autochthonous, were diagnosed primarily in older immunosuppressed individuals, and were generally treated with liposomal amphotericin B. The findings suggest a need for enhanced surveillance and reporting, clinical awareness, and diagnostic capacity of these forms of leishmaniasis to mitigate underdiagnosis and improve patient outcomes. A holistic One Health approach is advocated to address the multifaceted challenges posed by leishmaniases in Portugal and beyond.

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